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Pathway Description
Isoleucine Degradation
Streptomyces avermitilis
Metabolic Pathway
Isoleucine degradation is a vital metabolic process that breaks down the essential amino acid isoleucine into intermediates that feed into the tricarboxylic acid (TCA) cycle, facilitating energy production and various biosynthetic pathways. This pathway involves multiple enzymatic steps that convert isoleucine into acetyl-CoA and propionyl-CoA, key molecules for cellular metabolism. These reactions help in generating energy and providing building blocks for the synthesis of other important compounds.
References
Isoleucine Degradation References
Kanehisa, M., 2002, November. The KEGG database. In ‘In silico’simulation of biological processes: Novartis Foundation Symposium 247 (Vol. 247, pp. 91-103). Chichester, UK: John Wiley & Sons, Ltd.
UniProt Consortium, 2019. UniProt: a worldwide hub of protein knowledge. Nucleic acids research, 47(D1), pp.D506-D515.
Kim, S., Thiessen, P.A., Bolton, E.E., Chen, J., Fu, G., Gindulyte, A., Han, L., He, J., He, S., Shoemaker, B.A. and Wang, J., 2016. PubChem substance and compound databases. Nucleic acids research, 44(D1), pp.D1202-D1213.
de Matos, P., Adams, N., Hastings, J., Moreno, P. and Steinbeck, C., 2012. A database for chemical proteomics: ChEBI. Chemical Proteomics: Methods and Protocols, pp.273-296.
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from PW273734
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