PathWhiz

Pathway Description

Alcaligin Siderophore Repression (alcABC Operon activation)

Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

Metabolic Pathway

The alcABC operon, is involved in the production of alcaligin, a siderophore that helps bacteria acquire iron from the host environment. The operon is made up of 3 genes - alcA, alcB, and alcC. AlcA encodes a protein believed to be involved in the initial steps of alcaligin biosynthesis. alcB encodes a protein also involved in the biosynthesis of alcaligin. AlcC encodes a protein that is similar to IucC, another enzyme involved in siderophore biosynthesis. The operon is regulated by iron availability. It is repressed in the presence of iron. The transcriptional regulator protein Fur (ferric uptake regulator) binds to the promoter region of the operon when iron is abundant, inhibiting transcription, ensuring that the operon is only expressed when iron is scarce.

References

Alcaligin Siderophore Repression (alcABC Operon activation) References

Okuda, S. and Yoshizawa, A.C., 2010. ODB: a database for operon organizations, 2011 update. Nucleic acids research, 39(suppl_1), pp.D552-D555.

Giardina PC, Foster LA, Toth SI, Roe BA, Dyer DW: Analysis of the alcABC operon encoding alcaligin biosynthesis enzymes in Bordetella bronchiseptica. Gene. 1997 Jul 18;194(1):19-24. doi: 10.1016/s0378-1119(97)00094-2.

Pubmed: 9266668

Highlighted elements will appear in red.

Highlight Compounds

Fe2+

Highlight Proteins

	Alcaligin biosynthesis enzyme
	Alcaligin biosynthesis protein
	Alcaligin biosynthesis protein
	Ferric uptake regulation protein

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Visualize Compound Data

Fe2+

Visualize Protein Data