PathWhiz

PathWhiz ID	Pathway	Meta Data
PW123964 View Pathway	metabolic Prodigiosin Biosynthesis Pseudoalteromonas rubra BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Aadhavya Sivakumaran Created On: July 06, 2020 at 11:29 Last Updated: July 06, 2020 at 11:29
PW127994 View Pathway	drug action Procyclidine M1 Antispasmodic Action Pathway Homo sapiens Procyclidine is an antispasmodic drug used to treat parkinsonism of various types and in the treatment of extrapyramidal symptoms. A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. Procyclidine has an atropine-like action on parasympathetic-innervated peripheral structures including smooth muscle. Its antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4. It is used to treat symptomatic Parkinsonism and extrapyramidal dysfunction caused by antipsychotic agents. The mechanism of action is unknown. It is thought that Procyclidine acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Many of its effects are due to its pharmacologic similarities with atropine. Procyclidine exerts an antispasmodic effect on smooth muscle, and may produce mydriasis and reduction in salivation. By blocking the M1 receptor, the action of acetylcholine is blocked. Procyclidine is administered as an oral tablet. Possible side effects of using procyclidine may include flushing, pupil dilation, blurred vision, and dry mouth. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: June 27, 2023 at 14:47 Last Updated: June 27, 2023 at 14:47
PW144512 View Pathway	drug action Procyclidine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:47 Last Updated: October 07, 2023 at 13:47
PW132453 View Pathway	metabolic Procyclidine Drug Metabolism Homo sapiens Procyclidine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Procyclidine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:52 Last Updated: September 21, 2023 at 21:52
PW128206 View Pathway	drug action Prochlorperazine Mechanism of Action Action Pathway Homo sapiens Prochlorperazine is administered orally. It is a phenothiazine derivative, used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Dopamine-antagonizing medications such as prochlorperazine are thought to improve psychotic symptoms and states that are caused by an over-production of dopamine, such as schizophrenia, which is theorized to be caused by a hyperdopaminergic state within the limbic system of the brain. Use of the first-generation antipsychotics (including prochlorperazine) is considered effective for the management of the "positive" symptoms of schizophrenia including hallucinations, hearing voices, aggression/hostility, disorganized speech, and psychomotor agitation. However, this class of drugs is also limited by the development of movement disorders induced by dopamine-blockade such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. It depresses the chemoreceptor trigger zone and blocking D2 dopamine receptors in the brain. It was shown to also block histaminergic, cholinergic and noradrenergic receptors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 02, 2023 at 08:52 Last Updated: August 02, 2023 at 08:52
PW144558 View Pathway	drug action Prochlorperazine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:53 Last Updated: October 07, 2023 at 13:53
PW126853 View Pathway	drug action Prochlorperazine Action Pathway (New) Homo sapiens Prochlorperazine is an oral drug that is a phenothiazine derivative, used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Dopamine-antagonizing medications such as prochlorperazine are though to improve psychotic symptoms and states that are caused by an over-production of dopamine, such as schizophrenia, which is theorized to be caused by a hyperdopaminergic state within the limbic system of the brain. Use of the first-generation antipsychotics (including prochlorperazine) is considered effective for the management of the "positive" symptoms of schizophrenia including hallucinations, hearing voices, aggression/hostility, disorganized speech, and psychomotor agitation. However, this class of drugs is also limited by the development of movement disorders induced by dopamine-blockade such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. It is used for the treatment of severe nausea and vomiting. It mainly works by depressing the chemoreceptor trigger zone and blocking D2 dopamine receptors in the brain. It was shown to also block histaminergic, cholinergic and noradrenergic receptors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: April 19, 2022 at 21:50 Last Updated: April 19, 2022 at 21:50
PW128231 View Pathway	drug action Prochlorperazine - Dopamine Antagonist Action Pathway Homo sapiens Prochlorperazine is administered orally. It is a phenothiazine derivative, used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Dopamine-antagonizing medications such as prochlorperazine are thought to improve psychotic symptoms and states that are caused by an over-production of dopamine, such as schizophrenia, which is theorized to be caused by a hyperdopaminergic state within the limbic system of the brain. Use of the first-generation antipsychotics (including prochlorperazine) is considered effective for the management of the "positive" symptoms of schizophrenia including hallucinations, hearing voices, aggression/hostility, disorganized speech, and psychomotor agitation. However, this class of drugs is also limited by the development of movement disorders induced by dopamine-blockade such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. It depresses the chemoreceptor trigger zone and blocking D2 dopamine receptors in the brain. It was shown to also block histaminergic, cholinergic and noradrenergic receptors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 04, 2023 at 11:21 Last Updated: August 04, 2023 at 11:21
PW176287 View Pathway	metabolic Procaterol Predicted Metabolism Pathway Homo sapiens Metabolites of Procaterol are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:42 Last Updated: December 04, 2023 at 14:42
PW145398 View Pathway	drug action Procaterol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:44 Last Updated: October 07, 2023 at 15:44