PathWhiz

PathWhiz ID	Pathway	Meta Data
PW000125 View Pathway	drug action Piroxicam Action Pathway Homo sapiens Piroxicam (also named Feldene or Piroxicamum) is a nonsteroidal anti-inflammatory drug. Piroxicam can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. Decreased prostaglandin synthesis in many animal model's cell is caused by presence of piroxicam. Piroxicam can prevent movement of leukocytes to inflammation site so that thromboxane A2 can't be produced. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 04, 2013 at 12:28 Last Updated: August 04, 2013 at 12:28
PW122326 View Pathway	drug action Piroxicam Action Action Pathway Xuan (Demo Purpose) 2 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: January 17, 2019 at 14:24 Last Updated: January 17, 2019 at 14:24
PW122274 View Pathway	drug action Piroxicam Action Action Pathway Xuan (Demo Purpose) Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: xuan cao Created On: October 29, 2018 at 14:59 Last Updated: October 29, 2018 at 14:59
PW122252 View Pathway	drug action Piroxicam Action Action Pathway Xuan Homo sapiens Piroxicam is a nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects. Piroxicam will be transported via Solute carrier family 22 member 6, Solute carrier family 22 member 8, Solute carrier family 22 member 11 and Solute carrier organic anion transporter family member 2B1 into cell. After get into cell, piroxicam will inhibit the Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1's function; so that Prostaglandin G2 couldn't be transferred into Prostaglandin H2. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: xuan cao Created On: October 14, 2018 at 17:49 Last Updated: October 14, 2018 at 17:49
PW176399 View Pathway	metabolic Piritramide Predicted Metabolism Pathway Homo sapiens Metabolites of Piritramide are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:49 Last Updated: December 07, 2023 at 16:49
PW128420 View Pathway	drug action Piritramide Opioid Agonist Action Pathway Homo sapiens Piritramide is an opioid analgesic used to treat severe pain. It is under investigation for the treatment of colon cancer and minimal residual disease. Piritramide binds to mu, kappa, and delta opioid receptors on presynaptic neuron membranes, stimulating the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability. Morphine acts at A delta and C pain fibres in the dorsal horn of the spinal cord. By decreasing neurotransmitter action there is less pain transmittance into the spinal cord. This leads to less pain perception. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: August 28, 2023 at 13:31 Last Updated: August 28, 2023 at 13:31
PW146535 View Pathway	drug action Piritramide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:26 Last Updated: October 07, 2023 at 18:26
PW176227 View Pathway	metabolic Pirfenidone Predicted Metabolism Pathway Homo sapiens Metabolites of Pirfenidone are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 12:56 Last Updated: December 04, 2023 at 12:56
PW145620 View Pathway	drug action Pirfenidone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:14 Last Updated: October 07, 2023 at 16:14
PW145519 View Pathway	drug action Piretanide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:59 Last Updated: October 07, 2023 at 15:59