PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145677 View Pathway	drug action Silodosin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:22 Last Updated: October 07, 2023 at 16:22
PW146759 View Pathway	drug action Silodrate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:58 Last Updated: October 07, 2023 at 18:58
PW146574 View Pathway	drug action Silver Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:32 Last Updated: October 07, 2023 at 18:32
PW146220 View Pathway	drug action Silver nitrate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:42 Last Updated: October 07, 2023 at 17:42
PW132182 View Pathway	metabolic Silver sulfadiazine Drug Metabolism Homo sapiens Silver sulfadiazine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Silver sulfadiazine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 19:58 Last Updated: September 21, 2023 at 19:58
PW145633 View Pathway	drug action Silver sulfadiazine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:15 Last Updated: October 07, 2023 at 16:15
PW127522 View Pathway	drug action Simeprevir Action Pathway Homo sapiens Simeprevir is a direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4. Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated endocytosis. The lipoviroparticles attach to LDL-R and SR-B1, and then the virus binds to CD81 and subsequently claudin-1 and occludin, which mediate the late steps of viral entry. The virus is internalized by clathrin-dependent endocytosis. RNA is released from the mature Hepatitis C virion and translated at the rough endoplasmic reticulum into a single Genome polyprotein. Simeprevir accumulates in the liver after uptake into hepatocytes via solute carrier organic anion transporter family member 1B1. Simeprevir inhibits NS3/4A protease, which is an enzyme that cleaves the heptatitis C virus polyprotein downstream of the NS3 proteolytic site, which generates nonstructural proteins NS3, NS4A, NS4B, NS5A, and NS5B. These proteins are required in viral RNA replication, therefore because of the inhibition of their formation, RNA replication cannot occur. Because RNA replication does not occur, the mature virion is unable to form. At higher concentration above their antiviral half-maximal effective concentration (EC50), simeprevir and other NS3/4A inhibitors also restore interferon (IFN)-signaling pathways that are thought to be disrupted by NS3/4A protease and recover innate immune processes. NS3/4A protease cleaves two essential adaptor proteins that initiate signaling leading to activation of IFN regulatory factor 3 and IFN-α/β synthesis, which are mitochondrial antiviral-signaling proteins. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: April 05, 2023 at 09:22 Last Updated: April 05, 2023 at 09:22
PW145703 View Pathway	drug action Simeprevir Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:26 Last Updated: October 07, 2023 at 16:26
PW132193 View Pathway	metabolic Simethicone Drug Metabolism Homo sapiens Simethicone is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Simethicone passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:02 Last Updated: September 21, 2023 at 20:02
PW146182 View Pathway	drug action Simethicone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:36 Last Updated: October 07, 2023 at 17:36