PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128128 View Pathway	drug action Progesterone Action Pathway Homo sapiens Progesterone is a hormone naturally occurring in females. This molecule is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. It is used as an oral drug as a contraceptive to prevent ovulation and fertilization in certain formulations, as well as a promoter/supporter of pregnancy in other formulations. Pharmaceutical progesterone is made from a plant source as a starting material and is chemically identical to progesterone of human ovarian origin. Progesterone binds its receptor (located both on the membrane and in the cytosol) which activates a signaling pathway resulting in a lower release of GnRH by the hypothalamus. The lower concentration of GnRH results in the transcription of less LH and FSH hormones by the pituitary gland. The overall effect is that the ovaries can't release an egg (no ovulation) and the cervical mucus thicken to be unfavorable for sperm penetration. This drug is administered as an oral tablet/capsule for contraception and as a vaginal gel/insert to maintain the pregnancy. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: July 20, 2023 at 15:05 Last Updated: July 20, 2023 at 15:05
PW124133 View Pathway	signaling Metabolic pathways 1572044139 1598597734 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: August 28, 2020 at 00:55 Last Updated: August 28, 2020 at 00:55
PW123625 View Pathway	signaling Metabolic pathways 1572044139 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 25, 2019 at 16:56 Last Updated: October 25, 2019 at 16:56
PW013304 View Pathway	metabolic Metabolic pathways Mus musculus bdnf symthesis BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: May 02, 2017 at 07:48 Last Updated: May 02, 2017 at 07:48
PW064753 View Pathway	metabolic Mapa metabólico Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: June 10, 2018 at 16:58 Last Updated: June 10, 2018 at 16:58
PW124286 View Pathway	metabolic Mapa metabólico human mapa metabólico BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 27, 2020 at 17:18 Last Updated: October 27, 2020 at 17:18
PW128383 View Pathway	drug action Dosulepin Serotonin antagonist Action Pathway Homo sapiens Dosulepin is indicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required. Dosulepin displays affinity towards α2-adrenoceptors and to a lesser extent, α1-adrenoceptors. Inhibition of presynaptic α2-adrenoceptors by dosulepin facilitates noradrenaline release and further potentiates the antidepressant effects. It also downregulates central β-adrenoceptors by causing a decline in the number of receptors and reduces noradrenaline-induced cyclic AMP formation. Dosulepin binds to 5HT1A and 5HT2A receptors in the cerebral cortex and hippocampus as an antagonist. 5HT1A receptors are autoreceptors that inhibit 5HT release and 5HT2A receptors are Gi/Go-coupled receptors that reduces dopamine release upon activation. Antagonism at 5HT2A receptors may also improve sleep patterns. Dosulepin also binds to muscarinic acetylcholine receptors and causes antimuscarinic side effects such as dry mouth. By acting as an antagonist at histamine type 1 (H1) receptors, dosulepin mediates a sedative effect. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 25, 2023 at 11:16 Last Updated: August 25, 2023 at 11:16
PW128215 View Pathway	drug action Donepezil Action Pathway Homo sapiens Donepezil is an acetylcholinesterase inhibitor also known as Adlarity, Aricept and Namzaric, that is used in the treatment of Alzheimer's Disease and dementia. It is administered orally or transdermally, sometimes in combination with memantine in order to treat moderate to severe dementia. Donepezil selectively inhibits the acetylcholinesterase enzyme, by doing so it is believed to enhance cholinergic transmission to relieve the symptoms of Alzheimer's and dementia. Normally acetylcholinesterase breaks down acetylcholine, this inhibited its enhances cholinergic transmission. Donepezil goes through first-pass metabolism by CYP3A4 and CYP2D6 into metabolites which can be further broken down by dealkylation, hydroxylation, oxidation, hydrolysis and glucuronidation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 03, 2023 at 13:54 Last Updated: August 03, 2023 at 13:54
PW128196 View Pathway	drug action Donepezil Acetylcholinesterase Inhibitor Action Pathway Homo sapiens Donepezil is an acetylcholinesterase inhibitor that is used in the treatment of Alzheimer's Disease and dementia. It is administered orally or transdermally, sometimes in combination with memantine in order to treat moderate to severe dementia. Donepezil selectively inhibits the acetylcholinesterase enzyme, by doing so it is believed to enhance cholinergic transmission to relieve the symptoms of Alzheimer and dementia. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Anaya Created On: August 01, 2023 at 11:50 Last Updated: August 01, 2023 at 11:50
PW128386 View Pathway	drug action Dolasetron Serotonin antagonist Action Pathway Homo sapiens Dolasetron is a selective serotonin 5-HT3 receptor antagonist. In vivo, the drug is rapidly converted into its major active metabolite, hydrodolasetron, which seems to be largely responsible for the drug's pharmacological activity. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 25, 2023 at 12:02 Last Updated: August 25, 2023 at 12:02