PathWhiz

PathWhiz ID	Pathway	Meta Data
PW126600 View Pathway	metabolic Cannabinoid Biosynthesis Cannabis sativa Hexanoate is first catalyzed to make hexanoyl-CoA with the enzyme hexanoyl CoA synthase in the cytosol and within the membrane of the cell. Hexanoyl-CoA branches paths to olivetol biosynthesis which creates the byproducts of this pathway. The other pathway is catalyzed by olivetol synthase to make 3,5-dioxodecanoyl-CoA which is catalyzed to make 3,5,7-trioxododecanoyl-CoA. This is similar to the olivetol biosynthesis pathway, however here 3,5,7-trioxododecanoyl-CoA is catalyzed by olivetolic acid cyclase to make olivetolate. This takes place in the cytoplasm. Olivetolate along with geranyl diphosphate is catalyzed by olivetolate geranyltransferase to make cannabigerolate or cannabigerolic acid. This compound branches into three separate pathways each catalyzed by a different enzymes. One pathway is catalyzed by Δ9-tetrahydrocannabinolate synthase along with oxygen to make Δ9-tetrahydrocannabinolate. This compound spontaneously reacts with hydrogen to synthesize the drug Δ9-tetrahydrocannabinol (THC). The second pathway is catalyzed by cannabidiolate synthase and oxygen to make cannabidiolate or cannabidiolic acid. Cannabidiolate spontaneously reacts with hydrogen to synthesize the drug cannabidiol (CBD). The final pathway is catalyzed by cannabichromenate synthase along with an unknown oxidized electron carrier to make cannabichromenate or cannabichromenic acid. This, like the others, spontaneously reacts with hydrogen to synthesize the drug cannabichromene (CBC). BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: January 24, 2022 at 16:30 Last Updated: January 24, 2022 at 16:30
PW145945 View Pathway	drug action Cannabidiol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:02 Last Updated: October 07, 2023 at 17:02
PW124429 View Pathway	metabolic Cannabidiol and delta9-THC Biosynthesis Cannabis sativa BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: January 11, 2021 at 10:13 Last Updated: January 11, 2021 at 10:13
PW145715 View Pathway	drug action Cangrelor Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:27 Last Updated: October 07, 2023 at 16:27
PW132563 View Pathway	metabolic Cangrelor Drug Metabolism Homo sapiens Cangrelor is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Cangrelor passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:25 Last Updated: September 21, 2023 at 22:25
PW122421 View Pathway	drug action Cangrelor Action Pathway Homo sapiens Cangrelor, marketed as Kengreal or Kengrexal, is an antiplatelet drug that targets the P2Y12 receptor of platelets. It was developed as a derivative of ATP that is not enzymatically degraded by the cell. Cangrelor is already active, and is injected intravenously. Here, it binds to the P2Y purinoreceptor 12 on the surface of platelet cells, preventing ADP from binding to and activating it. Cangrelor prevents the activation of the Gi protein associated with the P2Y12 receptor from inactivating adenylate cyclase in the platelet, leading to a buildup of cAMP. This cAMP then activates calcium efflux pumps, preventing calcium buildup in the platelet, which would cause activation, and later, aggregation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: March 29, 2019 at 15:49 Last Updated: March 29, 2019 at 15:49
PW127405 View Pathway	drug action Candoxatril Homo sapiens Candoxatril is the prodrug of candoxatrilat that is activated via oral consumption, it is also a neutral endopeptidase inhibitor. It inhibits the metalloprotease enzymes, neutral endopeptidase and angiotensin-converting enzyme; inhibiting these enzymes increases peptides that act to induce vasodilation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: January 08, 2023 at 11:53 Last Updated: January 08, 2023 at 11:53
PW145240 View Pathway	drug action Candicidin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:23 Last Updated: October 07, 2023 at 15:23
PW127403 View Pathway	drug action Candicidin Action Pathway Homo sapiens Candicidin is a polyene antifungal antibiotic produced by a strain of Streptomyces griseus. It is especially effective against Candida albicans (more effective than amphotericin B), and is administered intravaginally in the treatment of vulvovaginal candidiasis. Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of Candicidin. Candicidin binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: January 05, 2023 at 15:47 Last Updated: January 05, 2023 at 15:47
PW175988 View Pathway	metabolic Candesartan cilexetil Predicted Metabolism Pathway new Homo sapiens Metabolites of Candesartan cilexetil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 13:02 Last Updated: November 29, 2023 at 13:02