PathWhiz

PathWhiz ID	Pathway	Meta Data
PW122261 View Pathway	metabolic Terpenoid Backbone Biosynthesis 1540198538 Saccharomyces cerevisiae The biosynthesis of steroids begins with acetyl coa being turned into acetoacetyl through a acetoacetyl CoA thiolase. Acetoacetyl -CoA reacts with an acetyl-CoA and water through a 3-hydroxy 3-methylglutaryl coenzyme A synthase resulting in the release of coenzyme A, hydrogen ion and (S)-3-hydroxy-3-methylglutaryl-CoA. The latter compound reacts with NADPH and a hydrogen ion through a 3-hydroxy-3-methylglutaryl-coenzyme A resulting in the release of coenzyme A , NADP and mevalonate. Mevalonate is then phosphorylated through an ATP driven kinase mevalonate kinase resulting in the release of ADP, hydrogen ion and mevalonate 5-phosphate. The latter compound is phosphorylated through an ATP driven kinase, phosphomevalonate kinase resulting in the release of ADP and mevalonate diphosphate. This latter compound then reacts with an ATP driven mevalonate diphosphate decarboxylase resulting in the release of ADP, carbon dioxide, a phosphate and a isopentenyl diphosphate. The latter compound can be isomerized into dimethylallyl diphosphate or reacth with a dimethylallyl diphosphate to produce geranyl diphosphate. Geranyl diphosphate reacts with a isopentenyl through a farnesyl diphosphate synthase resulting in the release of diphosphate and farnesyl diphosphate. Farnesyl diphosphate has three different fates: 1.-Producing hexaprenyl diphosphate in the mitocondrial inner membrane by reacting with 3 isopentenyl diphosphate 2.-Producing geranylgeranyl diphosphate in the cytoplasm by reacting with one isopentenyl diphosphate 3.-Producing a dolichol precursor in the ER by reacting with 13 isopentenyl diphosphates. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: October 22, 2018 at 02:55 Last Updated: October 22, 2018 at 02:55
PW122256 View Pathway	metabolic terpenoid Biosynthesis 1539750211 Bacteria Terpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway, and the non-mevalonate pathway or the MEP/DOXP pathway, for the terpenoid building blocks: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The action of prenyltransferases then generates higher-order building blocks: geranyl diphosphate (GPP), farsenyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP), which are the precursors of monoterpenoids (C10), sesquiterpenoids (C15), and diterpenoids (C20), respectively. Condensation of these building blocks gives rise to the precursors of sterols (C30) and carotenoids (C40). The MEP/DOXP pathway is absent in higher animals and fungi, but in green plants, the MEP/DOXP and mevalonate pathways co-exist in separate cellular compartments. The MEP/DOXP pathway, operating in the plastids, is responsible for the formation of essential oil monoterpenes and linalyl acetate, some sesquiterpenes, diterpenes, and carotenoids and phytol. The mevalonate pathway, operating in the cytosol, gives rise to triterpenes, sterols, and most sesquiterpenes. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 16, 2018 at 22:26 Last Updated: October 16, 2018 at 22:26
PW122257 View Pathway	metabolic terpenoid Biosynthesis 1539750211 Paenibacillus peoriae IBSD35 Terpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway, and the non-mevalonate pathway or the MEP/DOXP pathway, for the terpenoid building blocks: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The action of prenyltransferases then generates higher-order building blocks: geranyl diphosphate (GPP), farsenyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP), which are the precursors of monoterpenoids (C10), sesquiterpenoids (C15), and diterpenoids (C20), respectively. Condensation of these building blocks gives rise to the precursors of sterols (C30) and carotenoids (C40). The MEP/DOXP pathway is absent in higher animals and fungi, but in green plants, the MEP/DOXP and mevalonate pathways co-exist in separate cellular compartments. The MEP/DOXP pathway, operating in the plastids, is responsible for the formation of essential oil monoterpenes and linalyl acetate, some sesquiterpenes, diterpenes, and carotenoids and phytol. The mevalonate pathway, operating in the cytosol, gives rise to triterpenes, sterols, and most sesquiterpenes. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 16, 2018 at 22:38 Last Updated: October 16, 2018 at 22:38
PW132264 View Pathway	metabolic Terpin hydrate Drug Metabolism Homo sapiens Terpin hydrate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Terpin hydrate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:28 Last Updated: September 21, 2023 at 20:28
PW146598 View Pathway	drug action Terpin hydrate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:36 Last Updated: October 07, 2023 at 18:36
PW000996 View Pathway	signaling Test Homo sapiens Testing Pathwhiz BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: July 28, 2015 at 07:14 Last Updated: July 28, 2015 at 07:14
PW122370 View Pathway	signaling Test Test BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: March 10, 2019 at 20:20 Last Updated: March 10, 2019 at 20:20
PW027313 View Pathway	metabolic test Bos taurus BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: June 15, 2017 at 22:20 Last Updated: June 15, 2017 at 22:20
PW064790 View Pathway	signaling test Bacteria BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: July 13, 2018 at 08:08 Last Updated: July 13, 2018 at 08:08
PW123970 View Pathway	signaling test Mus musculus BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: 1169299218@qq.com Created On: July 08, 2020 at 03:51 Last Updated: July 08, 2020 at 03:51