PathWhiz

PathWhiz ID	Pathway	Meta Data
PW126604 View Pathway	drug action Thiocolchicoside Action Pathway (New) Homo sapiens Thiocolchicoside is a semi-synthetic colchicine derivative used as skeletal muscle-relaxant drug used in the treatment of orthopedic, traumatic and rheumatologic disorders. It is indicated as an adjuvant drug in the treatment of painful muscle contractures and is indicated in acute spinal pathology, for adults and adolescents 16 years of age and older.thiocolchicoside binds on the benzodiazepine receptors in the post-synaptic GABA-A ligand-gated chloride channel in different sites of the central nervous system (CNS). This binding will result in an increase on the GABA inhibitory effects which is translated as an increase in the flow of chloride ions into the cell causing hyperpolarization and stabilization of the cellular plasma membrane. Thiocolchicoside has a selective and potent afﬁnity for g-aminobutyric acid A (GABA-A) receptors and acts on muscular contractures by activating the GABA inhibitory pathways thereby behaving as a potent muscle relaxant. Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the human cortex. GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation, and anesthetics. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: January 25, 2022 at 23:26 Last Updated: January 25, 2022 at 23:26
PW124051 View Pathway	drug action Thioguanine Action Pathway Homo sapiens Thioguanine is an antineoplastic compound used to treat acute leukemia. It is usually administered orally and delivered to the site of action through the blood. Thioguanine has similar properties to 6-mercaptopurine as they share similar metabolites with the exception of 6-meraptopurine inhibiting the purine de novo synthesis pathway. Thioguanine's metabolites thiodeoxyguanosine-5'-triphosphate and thioguanosine 5'-triphosphate can be incorporated into DNA and RNA respectively which causes proliferation and protein synthesis to be inhibited. Thioguanosine 5'-triphosphate also inhibits ras-related C3 botulinum toxin substrate 1 a small GTPase membrane protein responsible for regulating cellular functions like cell growth, antimicrobial cytotoxicity, apoptosis regulation of lymphocytes. With ras-related C3 botulinum toxin substrate 1 being inhibited, apoptosis of T and B lymphocytes is no longer regulated and they are killed off. This leads to immunosuppression. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Kristen Yee Created On: August 08, 2020 at 11:45 Last Updated: August 08, 2020 at 11:45
PW000429 View Pathway	drug action Thioguanine Action Pathway (old) Homo sapiens Thioguanine is a purine antimetabolite prodrug closely related to mercaptopurine and similarly inhibits purine metabolism. The thioguanine pathway is shown as a part of the mercaptopurine pathway. Thioguanine exerts cytotoxic effects via incorporation of thiodeoxyguanosine triphosphate into DNA and thioguanosine triphosphate into RNA and inhibition of Ras-related C3 botulinum toxin substrate 1, which induces apoptosis of activated T cells. Once in a cell, thioguanine is converted to thioguanosine monophosphate by hypoxanthine-guanine phosphoribosyltransferase. Thioguanosine monophosphate is then phosphorylated to thioguanosine diphosphate, which is converted via a thiodeoxyguanosine diphosphate intermediate to thiodeoxyguanosine triphosphate. Thiodeoxyguanosine triphosphate is incorporated into DNA causing cytotoxicity. Thioguanosine diphosphate is also converted to thioguanosine triphosphate which is incorporated into RNA. The thioguanosine triphosphate metabolite also inhibits Ras-related C3 botulinum toxin substrate 1, a plasma membrane-associated small GTPase that regulates cellular processes, inducing apoptosis in activated T cells. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:46 Last Updated: August 22, 2013 at 10:46
PW146984 View Pathway	metabolic Thioguanine Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:35 Last Updated: October 10, 2023 at 13:35
PW000623 View Pathway	drug metabolism Thioguanine Metabolism Pathway (old) Homo sapiens Thioguanine is a purine antimetabolite prodrug closely related to mercaptopurine and similarly inhibits purine metabolism. The thioguanine pathway is shown as a part of the mercaptopurine pathway. Thioguanine exerts cytotoxic effects via incorporation of thiodeoxyguanosine triphosphate into DNA and thioguanosine triphosphate into RNA and inhibition of Ras-related C3 botulinum toxin substrate 1, which induces apoptosis of activated T cells. Once in a cell, thioguanine is converted to thioguanosine monophosphate by hypoxanthine-guanine phosphoribosyltransferase. Thioguanosine monophosphate is then phosphorylated to thioguanosine diphosphate, which is converted via a thiodeoxyguanosine diphosphate intermediate to thiodeoxyguanosine triphosphate. Thiodeoxyguanosine triphosphate is incorporated into DNA causing cytotoxicity. Thioguanosine diphosphate is also converted to thioguanosine triphosphate which is incorporated into RNA. The thioguanosine triphosphate metabolite also inhibits Ras-related C3 botulinum toxin substrate 1, a plasma membrane-associated small GTPase that regulates cellular processes, inducing apoptosis in activated T cells. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: September 18, 2013 at 09:42 Last Updated: September 18, 2013 at 09:42
PW146796 View Pathway	drug action Thiohexam Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:03 Last Updated: October 07, 2023 at 19:03
PW176357 View Pathway	metabolic Thiohexam Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:30 Last Updated: December 07, 2023 at 15:30
PW128417 View Pathway	drug action Thiopental Action Pathway Homo sapiens Thiopental is a barbiturate utilized for inducing general anesthesia, managing convulsions, and reducing intracranial pressure. Administered intravenously, this barbiturate is employed to induce general anesthesia promptly, achieve temporary complete anesthesia, induce hypnosis, and control convulsive conditions. Notably, it has been employed in neurosurgical contexts to alleviate elevated intracranial pressure. Although it lacks excitatory effects, its analgesic and muscle relaxant properties are limited. It has been shown that low doses can counteract analgesia and lower the pain threshold. Thiopental finds application as the sole anesthetic for brief procedures, as an induction agent preceding other anesthetics, to supplement regional anesthesia, to provide hypnosis alongside other agents for analgesia or muscle relaxation, for managing convulsions during inhalation or local anesthesia, in neurosurgical cases with heightened intracranial pressure, and for narcoanalysis and narcosynthesis in psychiatric disorders. Functioning as an ultrashort-acting central nervous system depressant, thiopental induces rapid hypnosis and anesthesia, yet it lacks analgesic properties. Its binding to a specific site linked to a Cl- ionopore at the GABAA receptor extends the opening duration of the ionopore, thereby prolonging GABA's inhibitory effect in the thalamus. This results in prolonged post-synaptic inhibition. The drug's rapid binding to fatty tissues leads to anesthetic accumulation, producing prolonged effects due to gradual drug release. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Dorsa Yahya Rayat Created On: August 28, 2023 at 13:07 Last Updated: August 28, 2023 at 13:07
PW144715 View Pathway	drug action Thiopental Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:17 Last Updated: October 07, 2023 at 14:17
PW146344 View Pathway	drug action Thioredoxin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:59 Last Updated: October 07, 2023 at 17:59