PathWhiz

PathWhiz ID	Pathway	Meta Data
PW091342 View Pathway	disease TSP-1 Induced Apoptosis in Microvascular Endothelial Cell Homo sapiens The members of the large family of matricellular proteins including thrombospondin-1 (TSP1) play important roles in genesis and remodeling of multiple tissues including cartilage and vasculature. TSP1 is one of the important pivots that regulate vascular tissue homeostasis whereas its key function is the negative control of angiogenesis. TSP1 was the first naturally occurring protein inhibitor of angiogenesis to be identified; its anti-angiogenic effects have since been established in a multitude of experimental models and linked to specific epitopes in the multi-domain, multi-functional TSP1 molecule. TSP1 is the first identified, and therefore best studied thrombospondin family representative, its structure is thus considered as prototype for the other family members. In the thrombospondin family, another member, TSP2 has a similar domain structure and, non-surprisingly, its functions significantly overlap with those of TSP1. Specifically, both TSP1 and TSP2 potently inhibit angiogenesis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Aidin Foroutannaddafi Created On: August 14, 2018 at 19:48 Last Updated: August 14, 2018 at 19:48
PW124299 View Pathway	signaling TTP Homo sapiens TTP BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: gabriel Created On: October 31, 2020 at 18:07 Last Updated: October 31, 2020 at 18:07
PW124298 View Pathway	signaling TTP Homo sapiens TTP BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: gabriel Created On: October 31, 2020 at 18:06 Last Updated: October 31, 2020 at 18:06
PW001990 View Pathway	drug action ttttt Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: September 16, 2015 at 02:48 Last Updated: September 16, 2015 at 02:48
PW145286 View Pathway	drug action Tubocurarine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:28 Last Updated: October 07, 2023 at 15:28
PW132546 View Pathway	metabolic Tucatinib Drug Metabolism Homo sapiens Tucatinib is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Tucatinib passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:22 Last Updated: September 21, 2023 at 22:22
PW146420 View Pathway	drug action Tucatinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:09 Last Updated: October 07, 2023 at 18:09
PW128379 View Pathway	drug action Turoctocog Alfa Action Pathway Homo sapiens Turoctocog alfa is a recombinant factor VIII, also known as Novoeight and Zonovate, used to treat bleeding in patients with haemophilia A which is a congenital factor VIII deficiency. It is administered intravenously and acts similarly to coagulation factor VIII, forming a complex with IX in order to activate factor X leading to a blood clot forming. Turoctocog alfa allows the missing factor coagulation VIII to be replaced and restore blood clotting. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 25, 2023 at 09:17 Last Updated: August 25, 2023 at 09:17
PW128461 View Pathway	drug action Turoctocog Alfa Pegol Action Pathway Homo sapiens Turoctocog alfa pegol is a version of turoctocog alfa also known as esperoct, used to treat hemophilia A. The difference between turoctocog alfa pegol and turoctocog alfa is the modification to the structure of turoctocog alfa pegol extends its half-life. It acts by replacing coagulation factor VIII which is deficient in patients with hemophilia. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 29, 2023 at 16:55 Last Updated: August 29, 2023 at 16:55
PW146244 View Pathway	drug action Turpentine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:46 Last Updated: October 07, 2023 at 17:46