PathWhiz

PathWhiz ID	Pathway	Meta Data
PW122272 View Pathway	metabolic acetic acid 1540693663 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 27, 2018 at 20:27 Last Updated: October 27, 2018 at 20:27
PW144925 View Pathway	drug action Acetazolamide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:43 Last Updated: October 07, 2023 at 14:43
PW123646 View Pathway	metabolic Acetate Metabolism 1573342891 Escherichia coli BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: November 09, 2019 at 16:41 Last Updated: November 09, 2019 at 16:41
PW002090 View Pathway	metabolic Acetate Metabolism Escherichia coli The acetate biosynthesis starts with acetyl-CoA reacting with phosphate through a phosphate acetyltransferase resulting in the release of a coenzyme A and an acetyl phosphate. The latter compound in turn reacts with ADP through an acetate kinase resulting in the release of an ATP and an acetate. The acetate reacts with ATP and coenzyme A through an acetyl-CoA synthase resulting in the release of a diphosphate, an AMP and an acetyl-CoA. Acetyl-CoA can be biosynthesized by acetoacetate reacting with an acetyl-CoA through an acetoacetyl-CoA transferase resulting in the release of an acetate and an acetoacetyl-CoA. The acetoacetyl-CoA reacts with an acetyl-CoA acetyltransferase resulting in the release of an coenzyme A and 2 acetyl-CoA BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: October 13, 2015 at 15:14 Last Updated: October 13, 2015 at 15:14
PW123562 View Pathway	metabolic Acetate Metabolism Pseudomonas aeruginosa The acetate biosynthesis starts with acetyl-CoA reacting with phosphate through a phosphate acetyltransferase resulting in the release of a coenzyme A and an acetyl phosphate. The latter compound in turn reacts with ADP through an acetate kinase resulting in the release of an ATP and an acetate. The acetate reacts with ATP and coenzyme A through an acetyl-CoA synthase resulting in the release of a diphosphate, an AMP and an acetyl-CoA. Acetyl-CoA can be biosynthesized by acetoacetate reacting with an acetyl-CoA through an acetoacetyl-CoA transferase resulting in the release of an acetate and an acetoacetyl-CoA. The acetoacetyl-CoA reacts with an acetyl-CoA acetyltransferase resulting in the release of an coenzyme A and 2 acetyl-CoA BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 22:32 Last Updated: August 12, 2019 at 22:32
PW146630 View Pathway	drug action Acetarsol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:40 Last Updated: October 07, 2023 at 18:40
PW132504 View Pathway	metabolic Acetarsol Drug Metabolism Homo sapiens Acetarsol is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Acetarsol passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:09 Last Updated: September 21, 2023 at 22:09
PW000616 View Pathway	drug metabolism Acetaminophen Metabolism Pathway Homo sapiens Acetaminophen (APAP) is metabolized primarily in the liver. Glucuronidation is the main route, accounting for 45-55% of APAP metabolism, and is mediatied by UGT1A1, UGT1A6, UGT1A9, UGT2B15 in the liver and UGT1A10 in the gut. APAP can also by metabolized via sulfation, accounting for 30-35% of the metabolism. In the liver, this step is catalyzed by the sulfotransferases SULT1A1, SULT1A3, SULT1A4, SULT1E1 and SULT2A1. Moreover, APAP can also be activated to form the toxic N-acetyl-p-benzoquinone imine (NAPQI) under the mediation of CYP3A4, CYP2E1, CYP2D6 CYP1A2, CYP2E1 and CYP2A6. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: September 11, 2013 at 22:33 Last Updated: September 11, 2013 at 22:33
PW144443 View Pathway	drug action Acetaminophen Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:38 Last Updated: October 07, 2023 at 13:38
PW124159 View Pathway	drug action Acetaminophen Action Pathway (New) Homo sapiens Acetaminophen is an oral/IV antipyretic and analgesic drug used to treat fevers and mild to moderate pain. Its exact mechanism is unknown but it is thought to target the cyclooxygenase pathway in the CNS (brain). It does not inhibit the cyclooxygenase pathway in peripheral tissues, an therefore, does not have any peripheral anti-inflammatory effect. The cyclooxygenase (COX) pathway begins in the cytosol with arachidonic acid being formed from membrane phospholipids via phospholipase A2. On the endoplasmic reticulum membrane, arachidonic acid is converted to prostaglandin G2 then to prostaglandin H2 using the enzymes prostaglandin G/H synthase 1 & 2 (COX-1 & COX-2). Prostaglandin H2 leads to the formation of thromboxane A2 (via thromboxane-A synthase), prostacyclin (via prostacyclin synthase) and prostaglandin E2 (via prostaglandin E synthase). Prostaglandin E2 (PGE2) is responsible for mediating pain and fever. Acetaminophen enters the cell through the solute carrier family 22-member 6 transporter and inhibits the COX-1 & COX-2 enzymes on the endoplasmic reticulum membrane. This prevents the production of prostaglandin H2 from arachidonic acid, thereby lowering the concentration of prostaglandin E2 in the cell. Since PGE2 causes pain and fever, reduction of PGE2 would lessen fevers and increase threshold for pain sensation. There are very few side effects associated with acetaminophen, but some people may have allergic reactions which may include itching, rash, difficulty breathing and swelling of face, hands, throat or mouth. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: September 13, 2020 at 14:56 Last Updated: September 13, 2020 at 14:56