PathWhiz

PathWhiz ID	Pathway	Meta Data
PW126201 View Pathway	metabolic 1-Methylhistidine Metabolism Homo sapiens Methylhistidine is a modified amino acid that is produced in myocytes during the methylation of actin and myosin. It is also formed from the methylation of L-histidine, which takes the methyl group from S-adenosylmethionine and forms S-adenosylhomocysteine as a byproduct. After its formation in the myocytes, methylhistidine enters the blood stream and travels to the kidneys, where it is excreted in the urine. Methylhistidine is present in the blood and urine in higher concentrations after skeletal muscle protein breakdown, which can occur due to disease or injury. Because of this, it can be used to judge how much muscle breakdown is occurring. Methylhistidine levels are also affected by diet, and may differ between vegetarian diets and those containing meats. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 23, 2021 at 15:10 Last Updated: August 23, 2021 at 15:10
PW002064 View Pathway	metabolic 1,6-Anhydro-N-acetylmuramic Acid Recycling Escherichia coli Most bacteria, including Escherichia coli, are composed of murein which protects and stabilizes the cell wall. Over half of the murein is broken down by Escherichia coli and recycled for the next generation. The main muropeptide is GlcNAc-anhydro-N-acetylmuramic acid (anhMurNAc)-l-Ala-γ-d-Glu-meso-Dap-d-Ala which enters the cytoplasm by AmpG protein. The peptide is then released from the muropeptide. 1,6-Anhydro-N-acetylmuramic acid (anhMurNAc) is recycled by its conversion to N-acetylglucosamine-phosphate (GlcNAc-P). The sugar is phosphorylated by anhydro-N-acetylmuramic acid kinase (AnmK) to produce MurNAc-P. Etherase cleaves MurNAc-P to produce N-acetyl-D-glucosamine 6-phosphate. The product can undergo further degradation or be recycled into peptidoglycan monomers. The pathway's final product is a peptidoglycan biosynthesis precursor, UDP-N-acetyl-α-D-muramate. The enzyme muropeptide ligase (mpl), attaches the recovered Ala-Glu-DAP tripeptide to the precursor UDP-N-acetyl-α-D-muramate to return to the peptide to the peptidoglycan biosynthetic pathway to synthesize the cell wall. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: October 09, 2015 at 12:00 Last Updated: October 09, 2015 at 12:00
PW123548 View Pathway	metabolic 1,6-Anhydro-N-acetylmuramic Acid Recycling Pseudomonas aeruginosa Most bacteria, including Escherichia coli, are composed of murein which protects and stabilizes the cell wall. Over half of the murein is broken down by Escherichia coli and recycled for the next generation. The main muropeptide is GlcNAc-anhydro-N-acetylmuramic acid (anhMurNAc)-l-Ala-γ-d-Glu-meso-Dap-d-Ala which enters the cytoplasm by AmpG protein. The peptide is then released from the muropeptide. 1,6-Anhydro-N-acetylmuramic acid (anhMurNAc) is recycled by its conversion to N-acetylglucosamine-phosphate (GlcNAc-P). The sugar is phosphorylated by anhydro-N-acetylmuramic acid kinase (AnmK) to produce MurNAc-P. Etherase cleaves MurNAc-P to produce N-acetyl-D-glucosamine 6-phosphate. The product can undergo further degradation or be recycled into peptidoglycan monomers. The pathway's final product is a peptidoglycan biosynthesis precursor, UDP-N-acetyl-α-D-muramate. The enzyme muropeptide ligase (mpl), attaches the recovered Ala-Glu-DAP tripeptide to the precursor UDP-N-acetyl-α-D-muramate to return to the peptide to the peptidoglycan biosynthetic pathway to synthesize the cell wall. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 22:30 Last Updated: August 12, 2019 at 22:30
PW146751 View Pathway	drug action 1,2-icosapentoyl-sn-glycero-3-phosphoserine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:57 Last Updated: October 07, 2023 at 18:57
PW146752 View Pathway	drug action 1,2-Distearoyllecithin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:57 Last Updated: October 07, 2023 at 18:57
PW146541 View Pathway	drug action 1,2-Benzodiazepine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:27 Last Updated: October 07, 2023 at 18:27
PW132374 View Pathway	metabolic 1,2-Benzodiazepine Drug Metabolism Homo sapiens 1,2-Benzodiazepine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. 1,2-Benzodiazepine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:19 Last Updated: September 21, 2023 at 21:19
PW147109 View Pathway	metabolic 1,1-Dimethylbiguanide Drug Metabolism Pathway Homo sapiens Gadoversetamide is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Gadoversetamide passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 11, 2023 at 09:28 Last Updated: October 11, 2023 at 09:28
PW123790 View Pathway	metabolic 1 Alloactinosynnema sp. L-07 BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: qhs Created On: February 07, 2020 at 22:05 Last Updated: February 07, 2020 at 22:05
PW126898 View Pathway	metabolic (-)-camphor biosynthesis Tanacetum vulgare (-)-camphor biosynthesis occurs in the species Tanactum vulgare, or the tansy. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: May 04, 2022 at 09:06 Last Updated: May 04, 2022 at 09:06