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Pathways

PathWhiz ID Pathway Meta Data

PW064722

Pw064722 View Pathway
signaling

AA

Homo sapiens

PW123596

Pw123596 View Pathway
signaling

A20 mechanism pathway 1560515737 1568969187

Homo sapiens

PW122528

Pw122528 View Pathway
signaling

A20 mechanism pathway 1560515737

Homo sapiens

PW012863

Pw012863 View Pathway
signaling

A20 mechanism pathway

Homo sapiens

PW128481

Pw128481 View Pathway
drug action

a Action Pathway

Homo sapiens
Human thrombin is a platelet-activating factor also known under the brand names Artiss, Evarrest, Evicel, Evithrom, Tachosil, Tisseel and Vistaseal. Human thrombin is purified human thrombin, a highly specific serine protease that acts on fibrinogen to fibrin, leading to the formation of a blood clot. It also acts on coagulation factor XIII to activate it and establish cross-linking of fibrin producing a clot. It is used as a topical application to a surgical site to minimize bleeding. Human thrombin is metabolized the same way as endogenous thrombin, inactivated by plasma inhibitors.

PW122161

Pw122161 View Pathway
physiological

a

Andrographolide

PW064708

Pw064708 View Pathway
disease

a

Bacteria

PW124259

Pw124259 View Pathway
protein

a

Homo sapiens

PW146992

Pw146992 View Pathway
metabolic

9-cis-Retinoic acid Drug Metabolism Pathway

Homo sapiens

PW121923

Pw121923 View Pathway
disease

5-Oxoprolinuria

Rattus norvegicus
5-Oxoprolinuria (5-Oxoprolinase deficiency) is a result of a defect in the gamma-glutamyl cycle due to either 5-oxoprolinase or glutathione synthetase deficiency. In the case of glutathione synthetase deficiency, the glycine is not incorporated into gamma-glutamylcysteine. In the case of 5-oxoprolinase, however, pyroglutamic acid accumulates. Symptoms include anemia, mental retardation, metabolic acidosis, respiratory distress and urolithiasis.