PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146906 View Pathway	drug action Upadacitinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:19 Last Updated: October 07, 2023 at 19:19
PW123957 View Pathway	signaling UPR Mus musculus UPR BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: July 03, 2020 at 15:45 Last Updated: July 03, 2020 at 15:45
PW002026 View Pathway	metabolic Uracil Degradation III Escherichia coli Uracil is a pyrimidine nucleobase found in RNA, and can be used as a source of nitrogen for E. coli. There are at least three pathways through which uracil is degraded. This one begins with uracil, which originates from purine degradation. The putative monooxygenase enzyme rutA catalyzes the breakdown of uracil into peroxyaminoacrylate, using FMNH2 as a cofactor. Peroxyaminoacrylate is then broken down into both carbamic acid and 3-aminoacrylate following the addition of a water molecule by the putative isochorismatase family protein rutB. Carbamic acid can then spontaneously, with the addition of a hydrogen ion, split into an ammonium ion and a molecule of carbon dioxide. 3-aminoacrylate, on the other hand, is catalyzed by the UPF0076 protein rutC to form 2-aminoacrylic acid. This compound enters into a reaction catalyzed by protein rutD, which adds a water molecule and hydrogen ion and forms malonic semialdehyde with ammonium being a byproduct. Finally, the putative NADH dehydrogenase/NAD(P)H nitroreductase rutE complex converts malonic semialdehyde into hydroxypropionic acid, which is then used to form other necessary chemicals. The ammonium ions produced will be the important source of nitrogen for the bacteria. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: October 01, 2015 at 14:20 Last Updated: October 01, 2015 at 14:20
PW123529 View Pathway	metabolic Uracil Degradation III Pseudomonas aeruginosa Uracil is a pyrimidine nucleobase found in RNA, and can be used as a source of nitrogen for E. coli. There are at least three pathways through which uracil is degraded. This one begins with uracil, which originates from purine degradation. The putative monooxygenase enzyme rutA catalyzes the breakdown of uracil into peroxyaminoacrylate, using FMNH2 as a cofactor. Peroxyaminoacrylate is then broken down into both carbamic acid and 3-aminoacrylate following the addition of a water molecule by the putative isochorismatase family protein rutB. Carbamic acid can then spontaneously, with the addition of a hydrogen ion, split into an ammonium ion and a molecule of carbon dioxide. 3-aminoacrylate, on the other hand, is catalyzed by the UPF0076 protein rutC to form 2-aminoacrylic acid. This compound enters into a reaction catalyzed by protein rutD, which adds a water molecule and hydrogen ion and forms malonic semialdehyde with ammonium being a byproduct. Finally, the putative NADH dehydrogenase/NAD(P)H nitroreductase rutE complex converts malonic semialdehyde into hydroxypropionic acid, which is then used to form other necessary chemicals. The ammonium ions produced will be the important source of nitrogen for the bacteria. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 22:26 Last Updated: August 12, 2019 at 22:26
PW144898 View Pathway	drug action Uracil mustard Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:39 Last Updated: October 07, 2023 at 14:39
PW012928 View Pathway	metabolic Urate Degradation to Glyoxylate Arabidopsis thaliana Purine nucleotides are eventually degraded to ammonia and carbon dioxide. This pathway begins in the peroxisome and follows the degradation a urate intermediate to glyoxylate. The last three steps take place in the endoplasmic reticulum. First, uricase converts urate into 5-hydroxyisourate. Steps two and three are catalyzed by the bifunctional enzyme S-allantoin synthase: the conversion of 5-hydroxyisourate into 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate (OHCU) and the conversion of OHCU into S-allantoin. Fourth, allantoinase requires zinc ion as a cofactor to catalyze the conversion of S-allantoin into allantoate. Next allantoate must be transported out of the peroxisome and into the endoplasmic reticulum. Fifth, allantoate amidohydrolase catalyzes the conversion of allantoate into S-ureidoglycine. This enzyme is a homodimer and requires manganese ion as a cofactor. Sixth, ureidoglycine aminohydrolase requires a manganese ion as a cofactor to catalyze the conversion of S-ureidoglycine into S-ureidoglycolate. Seventh, ureidoglycolate amidohydrolase catalyzes the conversion of S-ureidoglycolate into glyoxylate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: February 24, 2017 at 21:30 Last Updated: February 24, 2017 at 21:30
PW012915 View Pathway	metabolic Urate Degradation to Ureidoglycolate Arabidopsis thaliana Purine nucleotides are eventually degraded to ammonia and carbon dioxide. This pathway begins in the peroxisome and follows the degradation a urate intermediate to S-ureidoglycolate. The last two steps take place in the endoplasmic reticulum. First, uricase converts urate into 5-hydroxyisourate. Steps two and three are catalyzed by the bifunctional enzyme S-allantoin synthase: the conversion of 5-hydroxyisourate into 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate (OHCU) and the conversion of OHCU into S-allantoin. Fourth, allantoinase requires zinc ion as a cofactor to catalyze the conversion of S-allantoin into allantoate. Next allantoate must be transported out of the peroxisome and into the endoplasmic reticulum. Fifth, allantoate amidohydrolase catalyzes the conversion of allantoate into S-ureidoglycine. This enzyme is a homodimer and requires manganese ion as a cofactor. Sixth, ureidoglycine aminohydrolase requires a manganese ion as a cofactor to catalyze the conversion of S-ureidoglycine into S-ureidoglycolate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: February 24, 2017 at 15:48 Last Updated: February 24, 2017 at 15:48
PW132171 View Pathway	metabolic Urea C-13 Drug Metabolism Homo sapiens Urea C-13 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Urea C-13 passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 19:55 Last Updated: September 21, 2023 at 19:55
PW146180 View Pathway	drug action Urea C-13 Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:36 Last Updated: October 07, 2023 at 17:36
PW132170 View Pathway	metabolic Urea C-14 Drug Metabolism Homo sapiens Urea C-14 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Urea C-14 passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 19:54 Last Updated: September 21, 2023 at 19:54