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Pathways

PathWhiz ID Pathway Meta Data

PW122161

Pw122161 View Pathway
physiological

a

Andrographolide

PW064708

Pw064708 View Pathway
disease

a

Bacteria

PW124259

Pw124259 View Pathway
protein

a

Homo sapiens

PW128481

Pw128481 View Pathway
drug action

a Action Pathway

Homo sapiens
Human thrombin is a platelet-activating factor also known under the brand names Artiss, Evarrest, Evicel, Evithrom, Tachosil, Tisseel and Vistaseal. Human thrombin is purified human thrombin, a highly specific serine protease that acts on fibrinogen to fibrin, leading to the formation of a blood clot. It also acts on coagulation factor XIII to activate it and establish cross-linking of fibrin producing a clot. It is used as a topical application to a surgical site to minimize bleeding. Human thrombin is metabolized the same way as endogenous thrombin, inactivated by plasma inhibitors.

PW012863

Pw012863 View Pathway
signaling

A20 mechanism pathway

Homo sapiens

PW122528

Pw122528 View Pathway
signaling

A20 mechanism pathway 1560515737

Homo sapiens

PW123596

Pw123596 View Pathway
signaling

A20 mechanism pathway 1560515737 1568969187

Homo sapiens

PW064722

Pw064722 View Pathway
signaling

AA

Homo sapiens

PW123594

Pw123594 View Pathway
metabolic

Aarginine

Homo sapiens

PW000714

Pw000714 View Pathway
drug action

Abacavir Action Pathway

Homo sapiens
Abacavir (also known as Ziagen or Epzicom) is an antiviral agent that is used for treating HIV/AID. Cellular enzyme converts abacavir to its activate metabolite, carbovir triphosphate, for inhibiting HIV-1 reverse transcriptase (RT) by competing with dGTP, which is the natural substrate of RT. Without HIV-1 reverse transcriptase, complementary DNA (cDNA) could not be generated; therefore, viral DNA couldn't be completed.