PathWhiz

PathWhiz ID	Pathway	Meta Data
PW127547 View Pathway	drug action INMAZEB Action Pathway Homo sapiens Atoltivimab (REGN 3470), Odesivimab (REGN 3471), and Maftivimab are monoclonal antibody (mAb) and part of the product, INMAZEB, containing three monoclonal IgG1K antibodies directed against the GP1 and GP2 glycoprotein of Zaire ebolavirus. INMAZEB, formally known as REGN-EB3, is a combination of Atoltivimab, Odesivimab, and Maftivimab in equimolar proportions. Each of them bind to a distinct portion of the GP1,2 glycoprotein and protect against ebola virus infection.It has not been established as efficacious for an other species within the Ebolavirus or Marburgvirua genera. INMAZEB is produced by Regeneron Pharmaceuticals and was granted FDA approval on October 14, 2020. Ebola virus (Zaire ebolavirus) has been responsible for at least 17 known outbreaks with an average fatality rate of 43.92%. Immune therapy using monoclonal antibodies (mAbs) is used to combat infectious diseases due to its rapid development, low toxicity, and high specificity. Ebola virus particles expose the glycoprotein, which is comprised of a trimer of GP1, and GP2 subunit heterodimers, connected by a disulfide bond, on their surface. Atoltivimab inhibits a distinct portion of the Zaire ebolavirus envelope glycoprotein. This blocks viral endocytosis and infection of the host cells. Atoltivimab exhibits strong (<90%) neutralization of chimeric lentiviral particles expressing Ebola virus. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: April 24, 2023 at 15:47 Last Updated: April 24, 2023 at 15:47
PW122578 View Pathway	metabolic Inner Membrane Transport Pseudomonas aeruginosa This pathway is a compilation of Escherichia coli inner membrane transport complexes that transport compounds from the periplasmic space into the cytosol. Many compound classes are carried by these inner membrane transport complexes including sugars, amino acids, and lipids. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 17:00 Last Updated: August 12, 2019 at 17:00
PW000786 View Pathway	metabolic Inner Membrane Transport Escherichia coli This pathway is a compilation of Escherichia coli inner membrane transport complexes that transport compounds from the periplasmic space into the cytosol. Many compound classes are carried by these inner membrane transport complexes including sugars, amino acids, and lipids. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: March 01, 2015 at 18:35 Last Updated: March 01, 2015 at 18:35
PW146595 View Pathway	drug action Inosine pranobex Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:35 Last Updated: October 07, 2023 at 18:35
PW146602 View Pathway	drug action Inositol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:36 Last Updated: October 07, 2023 at 18:36
PW088415 View Pathway	metabolic Inositol Metabolism Drosophila melanogaster The carbocyclic polyol inositol (otherwise known as myo-inositol) has a significant role in physiological systems as many secondary eukaryotic messengers derive their structure from inositol. Examples of secondary messengers derived from inositol include inositol phosphates, phosphatidylinositol (PI), and phosphatidylinositol phosphate (PIP) lipids. Inositol is abundant in many commonly consumed foods such as bran-rich cereals, beans, nuts, and fruit (particularly cantaloupe, melons, and oranges). It can also be synthesized by the body through the conversion of glucose-6-phosphate into mho-inositol under the following pathway: (1) glucose-6-phosphate undergoes isomerization due to the action of inositol-3-phosphate synthase (ASYNA1) which produces myo-inositol 3-phosphate; (2) myo-inositol 3-phosphate undergoes dephosphorylation via the action of inositol monophosphatase (IMPase 1) to produce myo-inositol. From this point, myo-inositol can move through multiple different fates depending on the secondary messenger being synthesized. For phosphatidyliositol, phosphatidylinositol synthase generates it with the substrates CDP-diacylglycerol and myo-inositol. Phosphatidyliositol can be modified further to generate phosphatidylinositol phosphate lipids via the action of class I, II and III phosphoinositide 3-kinases (PI 3-kinases). Other messengers (i.e. inositol phosphates) can be produced with the phospholipase C-mediated hydrolysis of phosphatidylinositol phosphates or with the action of other enzymes that remove or add phosphate groups. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 15:59 Last Updated: August 10, 2018 at 15:59
PW000143 View Pathway	metabolic Inositol Metabolism Homo sapiens The carbocyclic polyol inositol (otherwise known as myo-inositol) has a significant role in physiological systems as many secondary eukaryotic messengers derive their structure from inositol. Examples of secondary messengers derived from inositol include inositol phosphates, phosphatidylinositol (PI), and phosphatidylinositol phosphate (PIP) lipids. Inositol is abundant in many commonly consumed foods such as bran-rich cereals, beans, nuts, and fruit (particularly cantaloupe, melons, and oranges). It can also be synthesized by the body through the conversion of glucose-6-phosphate into mho-inositol under the following pathway: (1) glucose-6-phosphate undergoes isomerization due to the action of inositol-3-phosphate synthase (ASYNA1) which produces myo-inositol 3-phosphate; (2) myo-inositol 3-phosphate undergoes dephosphorylation via the action of inositol monophosphatase (IMPase 1) to produce myo-inositol. From this point, myo-inositol can move through multiple different fates depending on the secondary messenger being synthesized. For phosphatidyliositol, phosphatidylinositol synthase generates it with the substrates CDP-diacylglycerol and myo-inositol. Phosphatidyliositol can be modified further to generate phosphatidylinositol phosphate lipids via the action of class I, II and III phosphoinositide 3-kinases (PI 3-kinases). Other messengers (i.e. inositol phosphates) can be produced with the phospholipase C-mediated hydrolysis of phosphatidylinositol phosphates or with the action of other enzymes that remove or add phosphate groups. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 19, 2013 at 12:04 Last Updated: August 19, 2013 at 12:04
PW088478 View Pathway	metabolic Inositol Metabolism Caenorhabditis elegans The carbocyclic polyol inositol (otherwise known as myo-inositol) has a significant role in physiological systems as many secondary eukaryotic messengers derive their structure from inositol. Examples of secondary messengers derived from inositol include inositol phosphates, phosphatidylinositol (PI), and phosphatidylinositol phosphate (PIP) lipids. Inositol is abundant in many commonly consumed foods such as bran-rich cereals, beans, nuts, and fruit (particularly cantaloupe, melons, and oranges). It can also be synthesized by the body through the conversion of glucose-6-phosphate into mho-inositol under the following pathway: (1) glucose-6-phosphate undergoes isomerization due to the action of inositol-3-phosphate synthase (ASYNA1) which produces myo-inositol 3-phosphate; (2) myo-inositol 3-phosphate undergoes dephosphorylation via the action of inositol monophosphatase (IMPase 1) to produce myo-inositol. From this point, myo-inositol can move through multiple different fates depending on the secondary messenger being synthesized. For phosphatidyliositol, phosphatidylinositol synthase generates it with the substrates CDP-diacylglycerol and myo-inositol. Phosphatidyliositol can be modified further to generate phosphatidylinositol phosphate lipids via the action of class I, II and III phosphoinositide 3-kinases (PI 3-kinases). Other messengers (i.e. inositol phosphates) can be produced with the phospholipase C-mediated hydrolysis of phosphatidylinositol phosphates or with the action of other enzymes that remove or add phosphate groups. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 17:34 Last Updated: August 10, 2018 at 17:34
PW064607 View Pathway	metabolic Inositol Metabolism Mus musculus The carbocyclic polyol inositol (otherwise known as myo-inositol) has a significant role in physiological systems as many secondary eukaryotic messengers derive their structure from inositol. Examples of secondary messengers derived from inositol include inositol phosphates, phosphatidylinositol (PI), and phosphatidylinositol phosphate (PIP) lipids. Inositol is abundant in many commonly consumed foods such as bran-rich cereals, beans, nuts, and fruit (particularly cantaloupe, melons, and oranges). It can also be synthesized by the body through the conversion of glucose-6-phosphate into mho-inositol under the following pathway: (1) glucose-6-phosphate undergoes isomerization due to the action of inositol-3-phosphate synthase (ASYNA1) which produces myo-inositol 3-phosphate; (2) myo-inositol 3-phosphate undergoes dephosphorylation via the action of inositol monophosphatase (IMPase 1) to produce myo-inositol. From this point, myo-inositol can move through multiple different fates depending on the secondary messenger being synthesized. For phosphatidyliositol, phosphatidylinositol synthase generates it with the substrates CDP-diacylglycerol and myo-inositol. Phosphatidyliositol can be modified further to generate phosphatidylinositol phosphate lipids via the action of class I, II and III phosphoinositide 3-kinases (PI 3-kinases). Other messengers (i.e. inositol phosphates) can be produced with the phospholipase C-mediated hydrolysis of phosphatidylinositol phosphates or with the action of other enzymes that remove or add phosphate groups. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: January 21, 2018 at 21:38 Last Updated: January 21, 2018 at 21:38
PW088354 View Pathway	metabolic Inositol Metabolism Rattus norvegicus The carbocyclic polyol inositol (otherwise known as myo-inositol) has a significant role in physiological systems as many secondary eukaryotic messengers derive their structure from inositol. Examples of secondary messengers derived from inositol include inositol phosphates, phosphatidylinositol (PI), and phosphatidylinositol phosphate (PIP) lipids. Inositol is abundant in many commonly consumed foods such as bran-rich cereals, beans, nuts, and fruit (particularly cantaloupe, melons, and oranges). It can also be synthesized by the body through the conversion of glucose-6-phosphate into mho-inositol under the following pathway: (1) glucose-6-phosphate undergoes isomerization due to the action of inositol-3-phosphate synthase (ASYNA1) which produces myo-inositol 3-phosphate; (2) myo-inositol 3-phosphate undergoes dephosphorylation via the action of inositol monophosphatase (IMPase 1) to produce myo-inositol. From this point, myo-inositol can move through multiple different fates depending on the secondary messenger being synthesized. For phosphatidyliositol, phosphatidylinositol synthase generates it with the substrates CDP-diacylglycerol and myo-inositol. Phosphatidyliositol can be modified further to generate phosphatidylinositol phosphate lipids via the action of class I, II and III phosphoinositide 3-kinases (PI 3-kinases). Other messengers (i.e. inositol phosphates) can be produced with the phospholipase C-mediated hydrolysis of phosphatidylinositol phosphates or with the action of other enzymes that remove or add phosphate groups. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 14:41 Last Updated: August 10, 2018 at 14:41