PathWhiz

PathWhiz ID	Pathway	Meta Data
PW122364 View Pathway	metabolic Irinotecan Metabolism Mus musculus BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: March 06, 2019 at 16:36 Last Updated: March 06, 2019 at 16:36
PW122366 View Pathway	metabolic Irinotecan Metabolism Rattus norvegicus BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: March 06, 2019 at 16:36 Last Updated: March 06, 2019 at 16:36
PW122355 View Pathway	metabolic Irinotecan Metabolism Homo sapiens Irinotecan, branded as Camptosar, Campto, Onivyde and others, is a cancer medication used to treat colon and small cell lung cancers, alone or with other drugs. Irinotecan can be processed by the cytochrome P450 3A4 enzyme, producing both the side product glutaral, as well as a compound called NPC. the NPC can then be catalyzed by liver carboxylesterase 1 to form 7-ethyl-10-hydroxy-camptothecin, or SN-38. Alternatively, irinotecan can directly form SN-38 via catalysis by liver carboxylesterase 1. After its formation, SN-38 is converted to SN-38 glucuronide by UDP-glucuronosyltransferase 2B11. This can then be converted back to SN-38 in the lysosome by beta-glucuronidase, or can be excreted as the end product of the pathway. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: March 01, 2019 at 15:38 Last Updated: March 01, 2019 at 15:38
PW122367 View Pathway	metabolic Irinotecan Metabolism Danio rerio BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: March 06, 2019 at 16:36 Last Updated: March 06, 2019 at 16:36
PW122379 View Pathway	metabolic Irinotecan Metabolism Caenorhabditis elegans BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: March 11, 2019 at 20:47 Last Updated: March 11, 2019 at 20:47
PW000576 View Pathway	drug metabolism Irinotecan Metabolism Pathway Homo sapiens Irinotecan is a medication commonly sold as Camptosar, used to stop the growth of cancer cells, and to stop the spread of cancer cells in the human body. Specifically cancers of the rectum and of the colon. Commonly used in combination with chemotherapy. Irinotecan works through its active metabolite, SN-38, which inhibits the action of topoisomerase I. This enzyme is responsible for creating single-strand breaks in DNA during replication. These single-strands are reversible. SN-38 and Irinotecan binding to topoisomerase I-DNA complex results in the prevention of religation the DNA strand mentioned above, which creates double-strand DNA breakage. This breakage leads to cell death. Irinotecan is taken orally, but can also be injected. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: September 11, 2013 at 22:32 Last Updated: September 11, 2013 at 22:32
PW125961 View Pathway	drug action Irinotecan Topoisomerase Inhibitor Action Pathway Homo sapiens Irinotecan is a semi-synthetic analogue of camptothecin which is a topoisomerase IB inhibitor. It is used to treat colorectal cancer. It's mechanism of action against topoisomerase I is that it forms a tertiary complex between the DNA and the topoisomerase I enzyme causing double strand breaks. It first has to be metabolized by liver carboxylesterase 1 into SN-38, which is the active metabolite that inhibits topoisomerase. SN-38 can be inactivated by UGT1A1 into SN-38 glucuronide which upregulated in some individuals leading to irinotecan resistance. Individuals might also have a reduced function variant of UGT1A1 which can lead to increased metabolism of irinotecan and leads to irinotecan toxicity. Toxicity of irinotecan leads to gastrointestinal complications as well as nausea, vomiting and headaches. Irinotecan is administered usually intravenously as a solution. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Kristen Yee Created On: May 07, 2021 at 16:22 Last Updated: May 07, 2021 at 16:22
PW144995 View Pathway	drug action Iron Dextran Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:53 Last Updated: October 07, 2023 at 14:53
PW145461 View Pathway	drug action Iron Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:52 Last Updated: October 07, 2023 at 15:52
PW146503 View Pathway	drug action Iron isomaltoside 1000 Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:21 Last Updated: October 07, 2023 at 18:21