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PathWhiz ID Pathway Meta Data

PW000169

Pw000169 View Pathway
metabolic

Trehalose Degradation

Homo sapiens
Trehalose, also known as mycose or tremalose, is a sugar consisting of two 1-1 alpha bonded glucose molecules. It is produced by some plants, bacteria, fungi and invertebrates, and can be used as a source of energy, such as for flight in insects, and as a survival mechanism to avoid freezing and dehydration. After ingestion in the intestine lumen, trehalose can interact with trehalase, which exists in the brush border of the cells there. In a reaction that also requires a water molecule, it is broken. These are then transported into the epithelial cells along with a sodium ion by a sodium/glucose cotransporter, which can bring glucose up its gradient along with sodium moving down its gradient. Once inside the cell, the glucose can then be transported out of the basolateral membrane by a solute carrier family 2 facilitated glucose transporter. From there, the glucose enters the blood stream, and is transported to liver hepatocytes. Once in the liver, glucokinase can use the energy and phosphate from a molecule of ATP to form glucose-6-phosphate, which then goes on to start the process of glycolysis.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: WishartLab

Created On: August 19, 2013 at 12:04

Last Updated: August 19, 2013 at 12:04

PW088375

Pw088375 View Pathway
metabolic

Trehalose Degradation

Rattus norvegicus
Trehalose, also known as mycose or tremalose, is a sugar consisting of two 1-1 alpha bonded glucose molecules. It is produced by some plants, bacteria, fungi and invertebrates, and can be used as a source of energy, such as for flight in insects, and as a survival mechanism to avoid freezing and dehydration. After ingestion in the intestine lumen, trehalose can interact with trehalase, which exists in the brush border of the cells there. In a reaction that also requires a water molecule, it is broken. These are then transported into the epithelial cells along with a sodium ion by a sodium/glucose cotransporter, which can bring glucose up its gradient along with sodium moving down its gradient. Once inside the cell, the glucose can then be transported out of the basolateral membrane by a solute carrier family 2 facilitated glucose transporter. From there, the glucose enters the blood stream, and is transported to liver hepatocytes. Once in the liver, glucokinase can use the energy and phosphate from a molecule of ATP to form glucose-6-phosphate, which then goes on to start the process of glycolysis.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ana Marcu

Created On: August 10, 2018 at 15:18

Last Updated: August 10, 2018 at 15:18

PW353488

Pw353488 View Pathway
metabolic

Trehalose Degradation I (Low Osmolarity)

Providencia rustigianii DSM 4541
In E.coli, trehalose can be only synthesized with high osmolarity, and if the osmolarity is low, then the source of trehalose can be only obtained from external via transportation with trehalose PTS permease. However, sugar can be degraded with both low or high osmolarity in E.coli. Glucokinase can phosphorylate free gluocose into glucose-6-phosphate and both glucose-6-phosphate moieties enter glycolysis.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: November 08, 2024 at 22:12

Last Updated: November 08, 2024 at 22:12

PW354133

Pw354133 View Pathway
metabolic

Trehalose Degradation I (Low Osmolarity)

Vibrio fluvialis PG41
In E.coli, trehalose can be only synthesized with high osmolarity, and if the osmolarity is low, then the source of trehalose can be only obtained from external via transportation with trehalose PTS permease. However, sugar can be degraded with both low or high osmolarity in E.coli. Glucokinase can phosphorylate free gluocose into glucose-6-phosphate and both glucose-6-phosphate moieties enter glycolysis.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: November 09, 2024 at 15:05

Last Updated: November 09, 2024 at 15:05

PW352276

Pw352276 View Pathway
metabolic

Trehalose Degradation I (Low Osmolarity)

Megasphaera elsdenii DSM 20460
In E.coli, trehalose can be only synthesized with high osmolarity, and if the osmolarity is low, then the source of trehalose can be only obtained from external via transportation with trehalose PTS permease. However, sugar can be degraded with both low or high osmolarity in E.coli. Glucokinase can phosphorylate free gluocose into glucose-6-phosphate and both glucose-6-phosphate moieties enter glycolysis.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: November 08, 2024 at 14:27

Last Updated: November 08, 2024 at 14:27

PW354140

Pw354140 View Pathway
metabolic

Trehalose Degradation I (Low Osmolarity)

Brachyspira pilosicoli B2904
In E.coli, trehalose can be only synthesized with high osmolarity, and if the osmolarity is low, then the source of trehalose can be only obtained from external via transportation with trehalose PTS permease. However, sugar can be degraded with both low or high osmolarity in E.coli. Glucokinase can phosphorylate free gluocose into glucose-6-phosphate and both glucose-6-phosphate moieties enter glycolysis.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: November 09, 2024 at 15:12

Last Updated: November 09, 2024 at 15:12

PW354176

Pw354176 View Pathway
metabolic

Trehalose Degradation I (Low Osmolarity)

Mitsuokella multacida DSM 20544
In E.coli, trehalose can be only synthesized with high osmolarity, and if the osmolarity is low, then the source of trehalose can be only obtained from external via transportation with trehalose PTS permease. However, sugar can be degraded with both low or high osmolarity in E.coli. Glucokinase can phosphorylate free gluocose into glucose-6-phosphate and both glucose-6-phosphate moieties enter glycolysis.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: November 09, 2024 at 15:50

Last Updated: November 09, 2024 at 15:50

PW354164

Pw354164 View Pathway
metabolic

Trehalose Degradation I (Low Osmolarity)

Subdoligranulum variabile DSM 15176
In E.coli, trehalose can be only synthesized with high osmolarity, and if the osmolarity is low, then the source of trehalose can be only obtained from external via transportation with trehalose PTS permease. However, sugar can be degraded with both low or high osmolarity in E.coli. Glucokinase can phosphorylate free gluocose into glucose-6-phosphate and both glucose-6-phosphate moieties enter glycolysis.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: November 09, 2024 at 15:36

Last Updated: November 09, 2024 at 15:36

PW353476

Pw353476 View Pathway
metabolic

Trehalose Degradation I (Low Osmolarity)

Providencia rettgeri DSM 1131
In E.coli, trehalose can be only synthesized with high osmolarity, and if the osmolarity is low, then the source of trehalose can be only obtained from external via transportation with trehalose PTS permease. However, sugar can be degraded with both low or high osmolarity in E.coli. Glucokinase can phosphorylate free gluocose into glucose-6-phosphate and both glucose-6-phosphate moieties enter glycolysis.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: November 08, 2024 at 22:09

Last Updated: November 08, 2024 at 22:09

PW353426

Pw353426 View Pathway
metabolic

Trehalose Degradation I (Low Osmolarity)

Hafnia alvei ATCC 51873
In E.coli, trehalose can be only synthesized with high osmolarity, and if the osmolarity is low, then the source of trehalose can be only obtained from external via transportation with trehalose PTS permease. However, sugar can be degraded with both low or high osmolarity in E.coli. Glucokinase can phosphorylate free gluocose into glucose-6-phosphate and both glucose-6-phosphate moieties enter glycolysis.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: November 08, 2024 at 21:57

Last Updated: November 08, 2024 at 21:57