PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146640 View Pathway	drug action Tromantadine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:42 Last Updated: October 07, 2023 at 18:42
PW132392 View Pathway	metabolic Tromethamine Drug Metabolism Homo sapiens Tromethamine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Tromethamine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:25 Last Updated: September 21, 2023 at 21:25
PW145538 View Pathway	drug action Tromethamine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:02 Last Updated: October 07, 2023 at 16:02
PW064436 View Pathway	metabolic Tropane, Piperidine, and Pyridine Alkaloid Biosynthesis Arabidopsis thaliana Tropane, piperidine, and pyridine alkaloids are alkaloid compounds found in some plants containing a tropane, piperidine, or pyridine ring respectively . In Arabidopsis thaliana, the tropane, piperidine and pyridine alkaloid biosynthesis pathway consists of several separate reactions that are known. L-phenylalanine, which may be sourced from the phenylalanine, tyrosine, and tryptophan biosynthesis pathway or the phenylalanine metabolism pathway, may reversibly react with oxoglutaric acid to produce phenylpyruvate (aka. 2-oxo-3-phenylpropanoic acid) and L-glutamic acid. This reaction may be catalyzed by tyrosine aminotransferase, aspartate aminotransferase, or histidinol phosphate aminotransferase. Primary amine oxidase may catalyze the reactions of N-methylputrescine or cadaverine with oxygen and hydrogen to produce hydrogen peroxide, ammonia, and either 1-methylpyrrolinium or 5-aminopentanal respectively. Tropinone may react with hydrogen and NADPH to produce tropine and NADP, with catalyzation by tropinone reductase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Elvis Lo Created On: December 08, 2017 at 09:50 Last Updated: December 08, 2017 at 09:50
PW144916 View Pathway	drug action Tropicamide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:42 Last Updated: October 07, 2023 at 14:42
PW146430 View Pathway	drug action Tropisetron Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:10 Last Updated: October 07, 2023 at 18:10
PW128384 View Pathway	drug action Tropisetron Serotonin antagonist Action Pathway Homo sapiens Tropisetron is an indole derivative. Tropisetron competitively binds to and blocks the action of serotonin at 5HT3 receptors peripherally on vagus nerve terminals located in the gastrointestinal (GI) tract as well as centrally in the chemoreceptor trigger zone (CTZ) of the area postrema of the central nervous system (CNS). This results in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 25, 2023 at 11:59 Last Updated: August 25, 2023 at 11:59
PW127972 View Pathway	drug action Trospium Action Pathway Homo sapiens Ipratropium is an anticholinergic drug used in the control of symptoms related to bronchospasm in chronic obstructive pulmonary disease (COPD). It can be found under the brand names Atrovent, Combivent, and Ipravent. It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. Ipratropium acts as an antagonist of the muscarinic acetylcholine receptor. This effect produces the inhibition of the parasympathetic nervous system in the airways and hence, inhibit their function. The function of the parasympathetic system in the airway is to generate bronchial secretions and constriction and hence, the inhibition of this action can lead to bronchodilation and fewer secretions. At the cellular level, the diameter of the airways is controlled by the release of acetylcholine into the muscle cells causing them to contract and producing a narrow airway. Thus administration of ipratropium stops the activity of acetylcholine in the smooth muscle preventing the contraction and producing relaxed airways. Possible side effects of using trospium may include bladder pain, back pain, blurred vision, and dry mouth. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: June 26, 2023 at 10:53 Last Updated: June 26, 2023 at 10:53
PW144340 View Pathway	drug action Trospium Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:26 Last Updated: October 07, 2023 at 13:26
PW175935 View Pathway	metabolic Trospium Predicted Metabolism Pathway Homo sapiens Trospium PIS1M1 and Trospium PIIS2M1 are metabolites of Trospium predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 16, 2023 at 10:41 Last Updated: November 16, 2023 at 10:41