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PathWhiz ID Pathway Meta Data

PW132260

Pw132260 View Pathway
metabolic

Trolamine salicylate Drug Metabolism

Homo sapiens
Trolamine salicylate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Trolamine salicylate passes through the liver and is then excreted from the body mainly through the kidney.

PW146219

Pw146219 View Pathway
drug action

Trolamine salicylate Drug Metabolism Action Pathway

Homo sapiens

PW124332

Pw124332 View Pathway
drug action

Troleandomycin Action Pathway (New)

Bacteria
Troleandomycin is a macrolide antibiotic used for the treatment of bacterial infections of the upper and lower respiratory tract such as tonsilitis, bronchitis, sinusitis and pneumonia. Troleandomycin targets the protein synthesis machinery in the bacterial cytoplasm to inhibit protein synthesis and prevent bacterial growth. Troleandomycin enters through the bacterial cell membrane through multidrug resistant protein 1 and binds to the bacterial ribosome. The bacterial ribosome consists of two subunits: the 50s and the 30s subunit. Troleandomycin binds to the 50s subunit and prevents translocation of the tRNA along the A, P and E sites of the ribosome. Translocation of amino acids from the acceptor site (A site) to the donor site (P site) is prevented and as a result, protein synthesis is halted. The bacterial cells are unable to generate proteins necessary for growth and duplication, therefore, growth of the bacteria is inhibited. Side effects from taking troleandomycin may include abdominal cramping and discomfort, nausea and vomiting, diarrhea, dizziness, fatigue, headache, vaginal yeast infection and allergic reactions including urticaria, skin rashes and anaphylaxis.

PW000707

Pw000707 View Pathway
drug action

Troleandomycin Action Pathway

Homo sapiens
Troleandomycin, sold as Triocetin and Tekmisin, is a macrolide antibiotic drug. It is similar to erythromycin, the first macrolide discovered, as well as azithromycin and clarithromycin, which were formed from chemically modified erythromycin. As with other macrolides, troleandomycin binds to the bacterial ribosome, preventing ribosomal translation from occurring, as well as preventing amino acids from being added to the protein during protein biosynthesis. This prevents the bacteria from being able to produce potentially vital proteins, and means that the bacteria will likely die. Troleandomycin may inhibit some Cytochrome P450 enzymes, leading to averse effects to other drugs. Troleandomycin is used to treat pneumonia and streptococcal infection, but it is not yet FDA approved and is only currently used in Turkey.

PW146603

Pw146603 View Pathway
drug action

Troleandomycin Drug Metabolism Action Pathway

Homo sapiens

PW176501

Pw176501 View Pathway
metabolic

Troleandomycin Predicted Metabolism Pathway

Homo sapiens
Metabolites of Troleandomycin are predicted with biotransformer.

PW146640

Pw146640 View Pathway
drug action

Tromantadine Drug Metabolism Action Pathway

Homo sapiens

PW132392

Pw132392 View Pathway
metabolic

Tromethamine Drug Metabolism

Homo sapiens
Tromethamine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Tromethamine passes through the liver and is then excreted from the body mainly through the kidney.

PW145538

Pw145538 View Pathway
drug action

Tromethamine Drug Metabolism Action Pathway

Homo sapiens

PW064436

Pw064436 View Pathway
metabolic

Tropane, Piperidine, and Pyridine Alkaloid Biosynthesis

Arabidopsis thaliana
Tropane, piperidine, and pyridine alkaloids are alkaloid compounds found in some plants containing a tropane, piperidine, or pyridine ring respectively . In Arabidopsis thaliana, the tropane, piperidine and pyridine alkaloid biosynthesis pathway consists of several separate reactions that are known. L-phenylalanine, which may be sourced from the phenylalanine, tyrosine, and tryptophan biosynthesis pathway or the phenylalanine metabolism pathway, may reversibly react with oxoglutaric acid to produce phenylpyruvate (aka. 2-oxo-3-phenylpropanoic acid) and L-glutamic acid. This reaction may be catalyzed by tyrosine aminotransferase, aspartate aminotransferase, or histidinol phosphate aminotransferase. Primary amine oxidase may catalyze the reactions of N-methylputrescine or cadaverine with oxygen and hydrogen to produce hydrogen peroxide, ammonia, and either 1-methylpyrrolinium or 5-aminopentanal respectively. Tropinone may react with hydrogen and NADPH to produce tropine and NADP, with catalyzation by tropinone reductase.