PathWhiz ID | Pathway | Meta Data |
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PW127943View Pathway |
drug action
Trimipramine Action PathwayHomo sapiens
Trimipramine is a tricyclic antidepressant (TCA) used to treat depression accompanied or not by anxiety and agitation or sleep disturbance. It is very similar to imipramine but it has more antihistaminic and sedative properties. Trimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT) in the neurons. By binding to the sodium-dependent serotonin transporter and the sodium-dependent noradrenaline transporter, trimipramine fulfill its functions. Some side effects of its use include agitation, convulsions, irregular heart rate, muscle rigidity, stupor, and some others. This drug is administered as an oral tablet.
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Creator: Daphnee Created On: June 21, 2023 at 12:58 Last Updated: June 21, 2023 at 12:58 |
PW144838View Pathway |
drug action
Trimipramine Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 14:32 Last Updated: October 07, 2023 at 14:32 |
PW147100View Pathway |
drug action
Trimipramine H1 Antihistamine Neurological Sleep Action PathwayHomo sapiens
Trimipramine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria.
Wakefulness is regulated by histamine in the tuberomammillary nucleus, a part of the hypothalamus. Histidine is decarboxylated into histamine in the neuron. Histamine is transported into synaptic vesicles by a monoamine transporter then released into the synapse. Normally histamine would activate the H1 histamine receptor on the post-synaptic neuron in the tuberomammillary nucleus. Trimipramine inhibits the H1 histamine receptor, preventing the depolarization of the post-synaptic neuron. This prevents the wakefulness signal from being sent to the major areas of the brain, causing sleepiness.
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Creator: Ray Kruger Created On: October 10, 2023 at 14:47 Last Updated: October 10, 2023 at 14:47 |
PW127360View Pathway |
disease
Triosephosphate Isomerase DeficiencyHomo sapiens
Triosephosphate isomerase deficiency is a genetic disorder caused by a mutation in the TPI1 gene. The mutation of this gene causes the production of enzymes that are unstable or enzymes that have reduced activity. This means that cells have reduced energy supplies as glycolysis is compromised. This disorder causes anemia, movement problems and muscle weakness. As a result of the lack of red blood cells to carry oxygen through the body, patients may experience fatigue and shortness of breath. Movement problems appear in early infancy, typically before the age of 2 in patients with this disorder. Treatment includes blood transfusions.
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Creator: Ray Kruger Created On: December 16, 2022 at 11:07 Last Updated: December 16, 2022 at 11:07 |
PW122107View Pathway |
disease
Triosephosphate Isomerase DeficiencyRattus norvegicus
Triosephosphate isomerase deficiency is a genetic disorder caused by a mutation in the TPI1 gene. The mutation of this gene causes the production of enzymes that are unstable or enzymes that have reduced activity. This means that cells have reduced energy supplies as glycolysis is compromised. This disorder causes anemia, movement problems and muscle weakness. As a result of the lack of red blood cells to carry oxygen through the body, patients may experience fatigue and shortness of breath. Movement problems appear in early infancy, typically before the age of 2 in patients with this disorder. Treatment includes blood transfusions.
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Creator: Ana Marcu Created On: September 10, 2018 at 15:52 Last Updated: September 10, 2018 at 15:52 |
PW121883View Pathway |
disease
Triosephosphate Isomerase DeficiencyMus musculus
Triosephosphate isomerase deficiency is a genetic disorder caused by a mutation in the TPI1 gene. The mutation of this gene causes the production of enzymes that are unstable or enzymes that have reduced activity. This means that cells have reduced energy supplies as glycolysis is compromised. This disorder causes anemia, movement problems and muscle weakness. As a result of the lack of red blood cells to carry oxygen through the body, patients may experience fatigue and shortness of breath. Movement problems appear in early infancy, typically before the age of 2 in patients with this disorder. Treatment includes blood transfusions.
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Creator: Ana Marcu Created On: September 10, 2018 at 15:50 Last Updated: September 10, 2018 at 15:50 |
PW000539View Pathway |
disease
Triosephosphate Isomerase DeficiencyHomo sapiens
Triosephosphate isomerase deficiency is a genetic disorder caused by a mutation in the TPI1 gene. The mutation of this gene causes the production of enzymes that are unstable or enzymes that have reduced activity. This means that cells have reduced energy supplies as glycolysis is compromised. This disorder causes anemia, movement problems and muscle weakness. As a result of the lack of red blood cells to carry oxygen through the body, patients may experience fatigue and shortness of breath. Movement problems appear in early infancy, typically before the age of 2 in patients with this disorder. Treatment includes blood transfusions.
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Creator: WishartLab Created On: August 29, 2013 at 10:39 Last Updated: August 29, 2013 at 10:39 |
PW132405View Pathway |
Trioxsalen Drug MetabolismHomo sapiens
Trioxsalen is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Trioxsalen passes through the liver and is then excreted from the body mainly through the kidney.
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Creator: Ray Kruger Created On: September 21, 2023 at 21:31 Last Updated: September 21, 2023 at 21:31 |
PW145562View Pathway |
drug action
Trioxsalen Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 16:05 Last Updated: October 07, 2023 at 16:05 |
PW144899View Pathway |
drug action
Tripelennamine Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 14:39 Last Updated: October 07, 2023 at 14:39 |