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Pathways

PathWhiz ID Pathway Meta Data

PW144625

Pw144625 View Pathway
drug action

Ritonavir Drug Metabolism Action Pathway

Homo sapiens

PW126595

Pw126595 View Pathway
drug action

Rivaroxaban

Homo sapiens
Rivaroxaban is a factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations. Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Rivaroxaban is indicated for the prevention of venous thromboembolic events (VTE) in patients who have undergone total hips replacements and total knee replacement surgery; prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation; treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE); to reduce risk of recurrent DVT and/or PE. Rivaroxaban is also indicated, in combination with aspirin, for reducing the risk of major cardiovascular events in patients with chronic coronary artery disease or peripheral artery disease. Its use is also not recommended in those with severe renal impairment. Rivaroxaban competitively inhibits free and clot bound factor Xa. Factor Xa is needed to activate prothrombin (factor II) to thrombin (factor IIa). Thrombin is a serine protease that is required to activate fibrinogen to fibrin, which is the loose meshwork that completes the clotting process.

PW128037

Pw128037 View Pathway
drug action

Rivaroxaban Action Pathway

Homo sapiens
Rivaroxaban is an anticoagulant that inhibits coagulation factor X, typically used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). Rivaroxaban is indicated for patients at high risk of DVT, PE and any other recurrent thrombotic events. Rivaroxaban is also indicated, in combination with aspirin, for reducing the risk of major cardiovascular events in patients with chronic coronary artery disease or peripheral artery disease. Rivaroxaban competitively inhibits free and clot-bound factor X. Coagulation factor X makes up a part of the prothrombinase complex that is responsible for the conversion of prothrombin to thrombin. Thrombin is a serine protease that is required to activate fibrinogen to fibrin, which creates the loose meshwork that eventually forms into a blood clot. Patients should avoid herbs and supplements with anticoagulant activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. In addition, St. John's Wort should also be avoided as it will decrease blood concentration levels of rivaroxaban.

PW132486

Pw132486 View Pathway
metabolic

Rivaroxaban Drug Metabolism

Homo sapiens
Rivaroxaban is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Rivaroxaban passes through the liver and is then excreted from the body mainly through the kidney.

PW145688

Pw145688 View Pathway
drug action

Rivaroxaban Drug Metabolism Action Pathway

Homo sapiens

PW128009

Pw128009 View Pathway
drug action

Rivastigmine Action Pathway

Homo sapiens
Rivastigmine is a cholinesterase inhibitor used in the treatment of symptoms of dementia in Alzheimer's and Parkinson's. The drug reversible binds to and inhibits acetylcholinesterase and cholinesterase which stops the breakdown of acetylcholine which increases the concentration in the synaptic cleft. It is metabolized by the enzymes it inhibits and forms the metabolite NAP226-90.

PW128292

Pw128292 View Pathway
drug action

Rivastigmine Action Pathway (new)

Homo sapiens
Rivastigmine is a cholinesterase inhibitor used in the treatment of symptoms of dementia in Alzheimer's and Parkinson's. The drug reversible binds to and inhibits acetylcholinesterase and cholinesterase which stops the breakdown of acetylcholine which increases the concentration in the synaptic cleft. It is metabolized by the enzymes it inhibits and forms the metabolite NAP226-90.

PW145087

Pw145087 View Pathway
drug action

Rivastigmine Drug Metabolism Action Pathway

Homo sapiens

PW176230

Pw176230 View Pathway
metabolic

Rivastigmine Predicted Metabolism Pathway

Homo sapiens
Metabolites of Rivastigmine are predicted with biotransformer.

PW145052

Pw145052 View Pathway
drug action

Rizatriptan Drug Metabolism Action Pathway

Homo sapiens