PathWhiz

PathWhiz ID	Pathway	Meta Data
PW132333 View Pathway	metabolic Treosulfan Drug Metabolism Homo sapiens Treosulfan is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Treosulfan passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:57 Last Updated: September 21, 2023 at 20:57
PW146425 View Pathway	drug action Treosulfan Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:10 Last Updated: October 07, 2023 at 18:10
PW128116 View Pathway	drug action Treprostinil Action Pathway Homo sapiens Treprostinil is a stable tricyclic analogue of prostacyclin, it promotes vasodilation and inhibition of platelet aggregation. Treprostinil is administered either subcutaneously, orally or through inhalation used to treat pulmonary arterial hypertension as it acts as an anti-thrombotic agent and potent vasodilator. The drug binds and activates prostacyclin, prostaglandin D2 and P2Y purinoceptor 12 receptors that lead to activation and increased formation of cAMP levels. These elevated cAMP concentrations cause the efflux of calcium and calcium-activated potassium channels leading to cell hyperpolarization. Leading to the inhibition of platelet aggregation and vasodilation of the blood vessels. Treprostinil is metabolized by the liver by CYP2C8 and CYP2C into other metabolites that are excreted in urine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: July 19, 2023 at 11:15 Last Updated: July 19, 2023 at 11:15
PW144500 View Pathway	drug action Treprostinil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:46 Last Updated: October 07, 2023 at 13:46
PW175917 View Pathway	metabolic Triacylglyceride (TG) Pathway Homo sapiens A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are also present in the blood to enable the bidirectional transference of adipose fat and blood glucose from the liver, and are a major component of human skin oils (Wikipedia). Dihydroxyacetone phosphate (or glycerone phosphate) from glycolysis is used by the cytosolic enzyme glycerol-3-phosphate dehydrogenase [NAD(+)] to synthesize sn-glycerol 3-phosphate. Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic acid or LPA). The next three steps are localized to the endoplasmic reticulum membrane. The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone. Next, magnesium-dependent phosphatidate phosphatase catalyzes the conversion of phosphatidic acid into diacylglycerol. Last, the enzyme diacylglycerol O-acyltransferase synthesizes triacylglycerol from diacylglycerol and a fatty acyl-CoA. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: October 30, 2023 at 14:57 Last Updated: October 30, 2023 at 14:57
PW007513 View Pathway	metabolic Triacylglycerol biosynthesis through mitochondria Saccharomyces cerevisiae BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: August 04, 2016 at 10:16 Last Updated: August 04, 2016 at 10:16
PW012926 View Pathway	metabolic Triacylglycerol Degradation Arabidopsis thaliana In higher plants, the primary seed storage reserve is triacylglycerol rather than carbohydrates. Thus, triacylglycerol degradation is an important pathway from which plants obtain energy for growth. First, triacylglycerol lipase, an enzyme localized to the oil body (storage vacuole) membrane, catalyzes the conversion of a triglyceride into a 1,2-diglyceride. Second, the predicted enzyme diglyceride lipase (coloured orange in the image) is theorized to catalyze the conversion of a 1,2-diglyceride iinto a 2-acylglycerol. Third, a 2-acylglycerol is spontaneously converted into a 1-monoglyceride. Fourth, acylhydrolase catalyzes the conversion of a 1-monoglyceride into glycerol. Fifth, glycerol kinase catalyzes the conversion of glycerol into glycerol 3-phosphate. Sixth, glycerol-3-phosphate dehydrogenase (coloured dark green in the image), localized to the mitochondrial inner membrane, catalyzes the conversion of glycerol 3-phosphate into glycerone phosphate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: February 24, 2017 at 16:27 Last Updated: February 24, 2017 at 16:27
PW013331 View Pathway	metabolic Triacylglycerol Degradation TG(16:0/16:0/16:0) Arabidopsis thaliana In higher plants, the primary seed storage reserve is triacylglycerol rather than carbohydrates. Thus, triacylglycerol degradation is an important pathway from which plants obtain energy for growth. First, triacylglycerol lipase, an enzyme localized to the oil body (storage vacuole) membrane, catalyzes the conversion of a triglyceride into a 1,2-diglyceride. Second, the predicted enzyme diglyceride lipase (coloured orange in the image) is theorized to catalyze the conversion of a 1,2-diglyceride iinto a 2-acylglycerol. Third, a 2-acylglycerol is spontaneously converted into a 1-monoglyceride. Fourth, acylhydrolase catalyzes the conversion of a 1-monoglyceride into glycerol. Fifth, glycerol kinase catalyzes the conversion of glycerol into glycerol 3-phosphate. Sixth, glycerol-3-phosphate dehydrogenase (coloured dark green in the image), localized to the mitochondrial inner membrane, catalyzes the conversion of glycerol 3-phosphate into glycerone phosphate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: May 16, 2017 at 17:46 Last Updated: May 16, 2017 at 17:46
PW013332 View Pathway	metabolic Triacylglycerol Degradation TG(16:0/16:0/18:0) Arabidopsis thaliana In higher plants, the primary seed storage reserve is triacylglycerol rather than carbohydrates. Thus, triacylglycerol degradation is an important pathway from which plants obtain energy for growth. First, triacylglycerol lipase, an enzyme localized to the oil body (storage vacuole) membrane, catalyzes the conversion of a triglyceride into a 1,2-diglyceride. Second, the predicted enzyme diglyceride lipase (coloured orange in the image) is theorized to catalyze the conversion of a 1,2-diglyceride iinto a 2-acylglycerol. Third, a 2-acylglycerol is spontaneously converted into a 1-monoglyceride. Fourth, acylhydrolase catalyzes the conversion of a 1-monoglyceride into glycerol. Fifth, glycerol kinase catalyzes the conversion of glycerol into glycerol 3-phosphate. Sixth, glycerol-3-phosphate dehydrogenase (coloured dark green in the image), localized to the mitochondrial inner membrane, catalyzes the conversion of glycerol 3-phosphate into glycerone phosphate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: May 16, 2017 at 17:47 Last Updated: May 16, 2017 at 17:47
PW013334 View Pathway	metabolic Triacylglycerol Degradation TG(16:0/16:0/18:1(11Z)) Arabidopsis thaliana In higher plants, the primary seed storage reserve is triacylglycerol rather than carbohydrates. Thus, triacylglycerol degradation is an important pathway from which plants obtain energy for growth. First, triacylglycerol lipase, an enzyme localized to the oil body (storage vacuole) membrane, catalyzes the conversion of a triglyceride into a 1,2-diglyceride. Second, the predicted enzyme diglyceride lipase (coloured orange in the image) is theorized to catalyze the conversion of a 1,2-diglyceride iinto a 2-acylglycerol. Third, a 2-acylglycerol is spontaneously converted into a 1-monoglyceride. Fourth, acylhydrolase catalyzes the conversion of a 1-monoglyceride into glycerol. Fifth, glycerol kinase catalyzes the conversion of glycerol into glycerol 3-phosphate. Sixth, glycerol-3-phosphate dehydrogenase (coloured dark green in the image), localized to the mitochondrial inner membrane, catalyzes the conversion of glycerol 3-phosphate into glycerone phosphate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: May 16, 2017 at 17:47 Last Updated: May 16, 2017 at 17:47