PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145831 View Pathway	drug action Parecoxib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:46 Last Updated: October 07, 2023 at 16:46
PW128312 View Pathway	drug action Pargyline Action Pathway Homo sapiens Pargyline is a monoamine oxidase B inhibitor (MAOIs). This drug has antihypertensive properties and is, thus, indicated in the treatment of moderate to severe hypertension. Pargyline inhibits the breakdown of monoamine neurotransmitters, leading to an increase in their concentration in the neurons. There are 2 isoforms of this protein: A and B. The first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. The second one, the B isoform, breakdowns phenylethylamine, norepinephrine, epinephrine, dopamine, and tyramine. This isoform is found in the extracellular tissues and mainly in the brain. The mechanism of action of the MAOIs is still not determined, it is thought that they act by increasing free serotonin and norepinephrine concentrations and/or altering the concentrations of other amines in the CNS. MAO A inhibition is thought to be more relevant to antidepressant activity than the inhibition caused by MAO B. Selective MAO B inhibitors have no antidepressant effects. Pargyline functions by inhibiting the metabolism of catecholamines and tyramine in the presynaptic neuron. In general, catecholamines cause physiological changes to give the body the ability to respond to a fight-or-flight alarm. The typical effects are increases in heart rate, blood pressure, and blood glucose levels. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 17, 2023 at 13:58 Last Updated: August 17, 2023 at 13:58
PW128370 View Pathway	drug action Pargyline Amine Oxidase Serotonin Antidepressant Action Pathway Homo sapiens Pargyline is a monoamine oxidase B inhibitor (MAOI). This drug has antihypertensive properties and is, thus, indicated in treating moderate to severe hypertension. Pargyline inhibits the breakdown of monoamine neurotransmitters, leading to an increase in their concentration in the neurons. There are 2 isoforms of this protein: A and B. The first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. The second one, the B isoform, breakdowns phenylethylamine, norepinephrine, epinephrine, dopamine, and tyramine. This isoform is found in the extracellular tissues and mainly in the brain. The mechanism of action of the MAOIs is still not determined, it is thought that they act by increasing free serotonin and norepinephrine concentrations and/or altering the concentrations of other amines in the CNS. MAO-A inhibition is thought to be more relevant to antidepressant activity than the inhibition caused by MAO B. Selective MAO B inhibitors have no antidepressant effects—pargyline functions by inhibiting the metabolism of catecholamines and tyramine in the presynaptic neuron. In general, catecholamines cause physiological changes, allowing the body to respond to a fight-or-flight alarm. The typical effects are increases in heart rate, blood pressure, and blood glucose levels. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 24, 2023 at 13:37 Last Updated: August 24, 2023 at 13:37
PW145489 View Pathway	drug action Pargyline Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:56 Last Updated: October 07, 2023 at 15:56
PW145011 View Pathway	drug action Paricalcitol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:55 Last Updated: October 07, 2023 at 14:55
PW127526 View Pathway	drug action Paritaprevir Action Pathway Homo sapiens Paritaprevir is a direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections. Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated endocytosis. The lipoviroparticles attach to LDL-R and SR-B1, and then the virus binds to CD81 and subsequently claudin-1 and occludin, which mediate the late steps of viral entry. The virus is internalized by clathrin-dependent endocytosis. RNA is released from the mature Hepatitis C virion and translated at the rough endoplasmic reticulum into a single Genome polyprotein. Paritaprevir accumulates in the liver after uptake into hepatocytes via solute carrier organic anion transporter family member 1B1. Paritaprevir inhibits NS3/4A protease, which is an enzyme that cleaves the heptatitis C virus polyprotein downstream of the NS3 proteolytic site, which generates nonstructural proteins NS3, NS4A, NS4B, NS5A, and NS5B. These proteins are required in viral RNA replication, therefore because of the inhibition of their formation, RNA replication cannot occur. Because RNA replication does not occur, the mature virion is unable to form. At higher concentration above their antiviral half-maximal effective concentration (EC50), Paritaprevir and other NS3/4A inhibitors also restore interferon (IFN)-signaling pathways that are thought to be disrupted by NS3/4A protease and recover innate immune processes. NS3/4A protease cleaves two essential adaptor proteins that initiate signaling leading to activation of IFN regulatory factor 3 and IFN-α/β synthesis, which are mitochondrial antiviral-signaling proteins. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: April 06, 2023 at 12:11 Last Updated: April 06, 2023 at 12:11
PW146076 View Pathway	drug action Paritaprevir Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:21 Last Updated: October 07, 2023 at 17:21
PW176114 View Pathway	metabolic Paritaprevir Predicted Metabolism Pathway new Homo sapiens Metabolites of Paritaprevir are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:04 Last Updated: November 29, 2023 at 14:04
PW127759 View Pathway	drug action Parnaparin Action Pathway Homo sapiens Parnaparin is a low-weight molecular heparin (LWMH), an anticoagulant that acts on antithrombin III in order to inhibit coagulation. Inhibition of antithrombin III leads to no conversion of prothrombin to thrombin in addition to halting the conversion of fibrinogen to fibrin due to little concentrations of thrombin. It is usually administered subcutaneously and like other heparins has the risk of adverse effects such as deep vein thrombosis. It offers more toleration than heparin, as well as greater bioavailability and a longer half-life although more studies are being conducted to gain more insight into the therapeutic advantages of the drug. It can have interactions with food, it best to avoid herbs and supplements with anticoagulant and antiplatelet activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: May 30, 2023 at 15:48 Last Updated: May 30, 2023 at 15:48
PW146054 View Pathway	drug action Parnaparin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:18 Last Updated: October 07, 2023 at 17:18