PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146996 View Pathway	metabolic L-Carnitine Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:36 Last Updated: October 10, 2023 at 13:36
PW002110 View Pathway	metabolic L-Cysteine Degradation Escherichia coli The degradation of cysteine starts with L-cysteine reacting with l-cysteine desulfhydrase resulting in the release of a hydrogen sulfide, a hydrogen ion and a a 2-aminoprop-2-enoate. The latter compound in turn reacts spontaneously to form a 2-iminopropanoate. This compound in turn reacts spontaneously with water and a hydrogen ion resulting in the release of ammonium and pyruvate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: October 14, 2015 at 13:17 Last Updated: October 14, 2015 at 13:17
PW146973 View Pathway	metabolic L-Cysteine Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:33 Last Updated: October 10, 2023 at 13:33
PW270562 View Pathway	metabolic L-Glutamate Metabolism Shewanella denitrificans There are various ways by which glutamate enters the cytoplasm in E.coli, such as through a glutamate:sodium symporter, glutamate / aspartate : H+ symporter GltP or a glutamate / aspartate ABC transporter. Similarly, there are various ways by which E. coli synthesizes glutamate from L-glutamine or oxoglutaric acid. L-glutamine, introduced into the cytoplasm by glutamine ABC transporter, can either interact with glutaminase resulting in ammonia and L-glutamic acid, or react with oxoglutaric acid, and hydrogen ion through an NADPH driven glutamate synthase resulting in L-glutamic acid. L-glutamic acid is metabolized into L-glutamine by reacting with ammonium through a ATP driven glutamine synthase. L-glutamic acid can also be metabolized into L-aspartic acid by reacting with oxalacetic acid through an aspartate transaminase resulting in an oxoglutaric acid and L-aspartic acid. L-aspartic acid is metabolized into fumaric acid through an aspartate ammonia-lyase. Fumaric acid can be introduced into the cytoplasm through 3 methods: dicarboxylate transporter, C4 dicarboxylate / C4 monocarboxylate transporter DauA, and C4 dicarboxylate / orotate:H+ symporter. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: June 10, 2024 at 18:20 Last Updated: June 10, 2024 at 18:20
PW000789 View Pathway	metabolic L-Glutamate Metabolism Escherichia coli There are various ways by which glutamate enters the cytoplasm in E.coli, such as through a glutamate:sodium symporter, glutamate / aspartate : H+ symporter GltP or a glutamate / aspartate ABC transporter. Similarly, there are various ways by which E. coli synthesizes glutamate from L-glutamine or oxoglutaric acid. L-glutamine, introduced into the cytoplasm by glutamine ABC transporter, can either interact with glutaminase resulting in ammonia and L-glutamic acid, or react with oxoglutaric acid, and hydrogen ion through an NADPH driven glutamate synthase resulting in L-glutamic acid. L-glutamic acid is metabolized into L-glutamine by reacting with ammonium through a ATP driven glutamine synthase. L-glutamic acid can also be metabolized into L-aspartic acid by reacting with oxalacetic acid through an aspartate transaminase resulting in an oxoglutaric acid and L-aspartic acid. L-aspartic acid is metabolized into fumaric acid through an aspartate ammonia-lyase. Fumaric acid can be introduced into the cytoplasm through 3 methods: dicarboxylate transporter, C4 dicarboxylate / C4 monocarboxylate transporter DauA, and C4 dicarboxylate / orotate:H+ symporter. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: March 02, 2015 at 19:43 Last Updated: March 02, 2015 at 19:43
PW122581 View Pathway	metabolic L-Glutamate Metabolism Pseudomonas aeruginosa There are various ways by which glutamate enters the cytoplasm in E.coli, such as through a glutamate:sodium symporter, glutamate / aspartate : H+ symporter GltP or a glutamate / aspartate ABC transporter. Similarly, there are various ways by which E. coli synthesizes glutamate from L-glutamine or oxoglutaric acid. L-glutamine, introduced into the cytoplasm by glutamine ABC transporter, can either interact with glutaminase resulting in ammonia and L-glutamic acid, or react with oxoglutaric acid, and hydrogen ion through an NADPH driven glutamate synthase resulting in L-glutamic acid. L-glutamic acid is metabolized into L-glutamine by reacting with ammonium through a ATP driven glutamine synthase. L-glutamic acid can also be metabolized into L-aspartic acid by reacting with oxalacetic acid through an aspartate transaminase resulting in an oxoglutaric acid and L-aspartic acid. L-aspartic acid is metabolized into fumaric acid through an aspartate ammonia-lyase. Fumaric acid can be introduced into the cytoplasm through 3 methods: dicarboxylate transporter, C4 dicarboxylate / C4 monocarboxylate transporter DauA, and C4 dicarboxylate / orotate:H+ symporter. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 17:01 Last Updated: August 12, 2019 at 17:01
PW122418 View Pathway	metabolic L-Glutamate Metabolism Saccharomyces cerevisiae There are various ways by which glutamate enters the cytoplasm in E.coli. through a glutamate:sodium symporter, glutamate / aspartate : H+ symporter GltP or a glutamate / aspartate ABC transporter. There are various ways by which glutamate is synthesized from L-glutamine or oxoglutaric acid. L-glutamine, introduced into the cytoplasm by glutamine ABC transporter, can either interact with glutaminase resulting in ammonia and L-glutamic acid, or react with oxoglutaric acid, and hydrogen ion through an NADPH driven glutamate synthase resulting in L-glutamic acid. L-glutamic acid is metabolized into L-glutamine by reacting with ammonium through a ATP driven glutamine synthase. L-glutamic acid can also be metabolized into L-aspartic acid by reacting with oxalacetic acid through an aspartate transaminase resulting in oxoglutaric acid and L-aspartic acid. L-aspartic acid is metabolized into fumaric acid through an aspartate ammonia-lyase. Fumaric acid can be introduced into the cytoplasm through 3 methods: dicarboxylate transporter, C4 dicarboxylate / C4 monocarboxylate transporter DauA, and C4 dicarboxylate / orotate:H+ symporter. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Debra Lipton Created On: March 27, 2019 at 15:40 Last Updated: March 27, 2019 at 15:40
PW001886 View Pathway	metabolic L-glutamate metabolism II Escherichia coli BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: September 09, 2015 at 16:00 Last Updated: September 09, 2015 at 16:00
PW144273 View Pathway	drug action L-Glutamine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:04 Last Updated: October 07, 2023 at 13:04
PW122497 View Pathway	metabolic L-Homomethionine Biosynthesis Arabidopsis thaliana A non-protein amino acid and a derivative of methionine, homomethionine is synthesized through the process of chain elongation. In Arabidopsis thaliana and other members of the Cruciferae (Brassicaceae) family, it is synthesized as part of a multi-step pathway to generate glucosinolates. Glucosinolates are likely employed as a defense mechanism and are believed to be responsible for the pungent odour and taste associated with this plant family. The process starts in the cytosol of the plant cell with l-methionine as the primary substrate before moving into the chloroplast as 2-oxo-4-methylthiobutanoic acid. In the chloroplast, 3-isopropylmalate dehydratase plays a noteworthy role in catalyzing multiple reactions in the final synthesis of L-homomethionine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Chris Created On: May 06, 2019 at 10:58 Last Updated: May 06, 2019 at 10:58