PathWhiz

PathWhiz ID	Pathway	Meta Data
PW109038 View Pathway	signaling Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Bos taurus PGD is the major prostanoid released from human mast cells upon immunological challenge. Prostaglandin D2 (PGD2) can trigger asthmatic responses by acting as a cell-derived mediator in mice. The PGD receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 31, 2018 at 11:44 Last Updated: August 31, 2018 at 11:44
PW109027 View Pathway	signaling Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Mus musculus PGD is the major prostanoid released from human mast cells upon immunological challenge. Prostaglandin D2 (PGD2) can trigger asthmatic responses by acting as a cell-derived mediator in mice. The PGD receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 31, 2018 at 11:43 Last Updated: August 31, 2018 at 11:43
PW000451 View Pathway	signaling Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Homo sapiens PGD is the major prostanoid released from human mast cells upon immunological challenge. Prostaglandin D2 (PGD2) can trigger asthmatic responses by acting as a cell-derived mediator in mice. The PGD receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:46 Last Updated: August 22, 2013 at 10:46
PW109048 View Pathway	signaling Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Rattus norvegicus PGD is the major prostanoid released from human mast cells upon immunological challenge. Prostaglandin D2 (PGD2) can trigger asthmatic responses by acting as a cell-derived mediator in mice. The PGD receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 31, 2018 at 11:46 Last Updated: August 31, 2018 at 11:46
PW109049 View Pathway	signaling Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Rattus norvegicus Cyclooxygenase is the major producer of prostacyclin. Prostacyclin binding to its receptor increases vasodilation and decreases platelet aggregation. The receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response.In vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of myosin. This leads to smooth muscle relaxation resulting in vasodilation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 31, 2018 at 11:46 Last Updated: August 31, 2018 at 11:46
PW109039 View Pathway	signaling Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Bos taurus Cyclooxygenase is the major producer of prostacyclin. Prostacyclin binding to its receptor increases vasodilation and decreases platelet aggregation. The receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response.In vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of myosin. This leads to smooth muscle relaxation resulting in vasodilation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 31, 2018 at 11:44 Last Updated: August 31, 2018 at 11:44
PW109029 View Pathway	signaling Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Mus musculus Cyclooxygenase is the major producer of prostacyclin. Prostacyclin binding to its receptor increases vasodilation and decreases platelet aggregation. The receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response.In vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of myosin. This leads to smooth muscle relaxation resulting in vasodilation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 31, 2018 at 11:43 Last Updated: August 31, 2018 at 11:43
PW000452 View Pathway	signaling Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Homo sapiens Cyclooxygenase is the major producer of prostacyclin. Prostacyclin binding to its receptor increases vasodilation and decreases platelet aggregation. The receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response.In vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of myosin. This leads to smooth muscle relaxation resulting in vasodilation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:46 Last Updated: August 22, 2013 at 10:46
PW132377 View Pathway	metabolic Iobenguane Drug Metabolism Homo sapiens Iobenguane is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Iobenguane passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:20 Last Updated: September 21, 2023 at 21:20
PW145745 View Pathway	drug action Iobenguane Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:32 Last Updated: October 07, 2023 at 16:32