PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128225 View Pathway	drug action Pyridostigmine Action Pathway Homo sapiens Pyridostigmine is a cholinesterase inhibitor used for the treatment of myasthenia gravis. It is usually administered intravenously and is very similar to neostigmine but with a less adverse effect profile and longer duration of action. The autoimmune disease known as myasthenia gravis is characterized defect of acetylcholine interacting at the neuromuscular junction. This results in muscle weakness, muscle loss and overall fatigue. Pyridostigmine inhibits the breakdown of acetylcholine allowing for an increase in activation and relieving the aforementioned symptoms. It specifically targets and inhibits acetylcholinesterase and cholinesterase, this increases extracellular levels of acetylcholine. Pyridostigmine is administered orally or intravenously, the latter having a better bioavailability. It is hydrolyzed in the blood by cholinesterases and in the liver by microsomal enzymes in the liver. Its main metabolite is 3-hydroxy-N-methyl-pyridinium and eliminated through the urine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 03, 2023 at 22:07 Last Updated: August 03, 2023 at 22:07
PW144663 View Pathway	drug action Pyridostigmine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:09 Last Updated: October 07, 2023 at 14:09
PW144262 View Pathway	drug action Pyridoxal phosphate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:03 Last Updated: October 07, 2023 at 13:03
PW000547 View Pathway	disease Pyridoxine Dependency with Seizures Homo sapiens The condition pyridoxine dependent-epilepsy is a condition that sees seizures beginning in infancy. In some cases, the seizures begin before birth. The seizures involve status epilepticus, which are seizures that last several minutes. The symptoms specific to pyridoxine dependent seizures can include hypothermia, dystonia and irritability right before an episode. They also include loss of consciousness, convulsions, and muscle rigidity. Rarely does this condition manifest between 1 to 3 years of age, although it has occured. Traditional anticonvulsant medication has proven ineffective in patients with this condition; patients are instead treated with pyridoxine daily in large doses. This compound is a b-vitamin found in food. Encephalopathy can occur if this condition is not treated, which can result in permanent brain damage. Although this condition is treated with pyridoxine, it can still cause neurological issues, such as learning disorders or developmental delay, regardless of treatment. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 29, 2013 at 10:39 Last Updated: August 29, 2013 at 10:39
PW121891 View Pathway	disease Pyridoxine Dependency with Seizures Mus musculus The condition pyridoxine dependent-epilepsy is a condition that sees seizures beginning in infancy. In some cases, the seizures begin before birth. The seizures involve status epilepticus, which are seizures that last several minutes. The symptoms specific to pyridoxine dependent seizures can include hypothermia, dystonia and irritability right before an episode. They also include loss of consciousness, convulsions, and muscle rigidity. Rarely does this condition manifest between 1 to 3 years of age, although it has occured. Traditional anticonvulsant medication has proven ineffective in patients with this condition; patients are instead treated with pyridoxine daily in large doses. This compound is a b-vitamin found in food. Encephalopathy can occur if this condition is not treated, which can result in permanent brain damage. Although this condition is treated with pyridoxine, it can still cause neurological issues, such as learning disorders or developmental delay, regardless of treatment. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:50 Last Updated: September 10, 2018 at 15:50
PW127267 View Pathway	disease Pyridoxine Dependency with Seizures Homo sapiens The condition pyridoxine dependent-epilepsy is a condition that sees seizures beginning in infancy. In some cases, the seizures begin before birth. The seizures involve status epilepticus, which are seizures that last several minutes. The symptoms specific to pyridoxine dependent seizures can include hypothermia, dystonia and irritability right before an episode. They also include loss of consciousness, convulsions, and muscle rigidity. Rarely does this condition manifest between 1 to 3 years of age, although it has occured. Traditional anticonvulsant medication has proven ineffective in patients with this condition; patients are instead treated with pyridoxine daily in large doses. This compound is a b-vitamin found in food. Encephalopathy can occur if this condition is not treated, which can result in permanent brain damage. Although this condition is treated with pyridoxine, it can still cause neurological issues, such as learning disorders or developmental delay, regardless of treatment. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: November 24, 2022 at 18:26 Last Updated: November 24, 2022 at 18:26
PW122115 View Pathway	disease Pyridoxine Dependency with Seizures Rattus norvegicus The condition pyridoxine dependent-epilepsy is a condition that sees seizures beginning in infancy. In some cases, the seizures begin before birth. The seizures involve status epilepticus, which are seizures that last several minutes. The symptoms specific to pyridoxine dependent seizures can include hypothermia, dystonia and irritability right before an episode. They also include loss of consciousness, convulsions, and muscle rigidity. Rarely does this condition manifest between 1 to 3 years of age, although it has occured. Traditional anticonvulsant medication has proven ineffective in patients with this condition; patients are instead treated with pyridoxine daily in large doses. This compound is a b-vitamin found in food. Encephalopathy can occur if this condition is not treated, which can result in permanent brain damage. Although this condition is treated with pyridoxine, it can still cause neurological issues, such as learning disorders or developmental delay, regardless of treatment. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:52 Last Updated: September 10, 2018 at 15:52
PW144300 View Pathway	drug action Pyridoxine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:20 Last Updated: October 07, 2023 at 13:20
PW144336 View Pathway	drug action Pyrimethamine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:25 Last Updated: October 07, 2023 at 13:25
PW002063 View Pathway	metabolic Pyrimidine Deoxyribonucleosides Degradation Escherichia coli The degradation of deoxycytidine starts with deoxycytidine being introduced into the cytosol through either a nupG or nupC symporter. Once inside, it can can be degrade through water,a hydrogen ion and a deoxycytidien deaminsa resultin in the release of a ammonium and a a deoxyuridine. The deoxyuridine is then degraded through a uracil phosphorylase resulting in the release of a deoxyribose 1-phosphate and a uracil. The degradation of thymidine starts with thymidine being introduced into the cytosol through either a nupG or nupC symporter. Thymidine is then degrades through a phosphorylase resulting in the release of a thymine and a deoxyribose 1-phosphate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: October 09, 2015 at 11:52 Last Updated: October 09, 2015 at 11:52