PathWhiz

PathWhiz ID	Pathway	Meta Data
PW064787 View Pathway	protein Rac 1 Cell Motility Signaling Pathway Homo sapiens Rac1 is signaling protein part of the Rho GTPase family it is involved in cell motility, cell growth and cytoskeletal reorganization. Rac1 activity is regulated by guanine nucleotide exchange factors (GEFs). GEFs cause the release of GDP, allowing GDP to bind and Rac1 to become activated. GTPase-activated proteins (GAPs) down regulate the activity of GEFs be stimulating the inactivation via binding of GDP to Rac1. Active Rac1 stimulates proteins (ie. Wiskott–Aldrich syndrome) leading to actin polymerization. Actin polymerization is also regulated by cofilin. PAK proteins are critical effectors to cytoskeleton reorganization. PAK1 phosphorylates and activates LIM kinase. LIM kinase then phosphorylates cofilin, inactivating it leading to reduced actin filament severing and depolymerization, therby increasing polymerized actin. Rac1 stimulates lamellipodia and filopodia formation which are involved in cell movement and sensing the environment. It is proposed that PAK1 is involved in the phosphorylation of myosin light chain affecting myosin light chain phosphorylation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Debra Lipton Created On: July 04, 2018 at 15:19 Last Updated: July 04, 2018 at 15:19
PW122148 View Pathway	protein Rac 1 Cell Motility Signaling Pathway Rattus norvegicus Rac1 is signaling protein part of the Rho GTPase family it is involved in cell motility, cell growth and cytoskeletal reorganization. Rac1 activity is regulated by guanine nucleotide exchange factors (GEFs). GEFs cause the release of GDP, allowing GDP to bind and Rac1 to become activated. GTPase-activated proteins (GAPs) down regulate the activity of GEFs be stimulating the inactivation via binding of GDP to Rac1. Active Rac1 stimulates proteins (ie. Wiskott–Aldrich syndrome) leading to actin polymerization. Actin polymerization is also regulated by cofilin. PAK proteins are critical effectors to cytoskeleton reorganization. PAK1 phosphorylates and activates LIM kinase. LIM kinase then phosphorylates cofilin, inactivating it leading to reduced actin filament severing and depolymerization, therby increasing polymerized actin. Rac1 stimulates lamellipodia and filopodia formation which are involved in cell movement and sensing the environment. It is proposed that PAK1 is involved in the phosphorylation of myosin light chain affecting myosin light chain phosphorylation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 14, 2018 at 17:49 Last Updated: September 14, 2018 at 17:49
PW122144 View Pathway	protein Rac 1 Cell Motility Signaling Pathway Mus musculus Rac1 is signaling protein part of the Rho GTPase family it is involved in cell motility, cell growth and cytoskeletal reorganization. Rac1 activity is regulated by guanine nucleotide exchange factors (GEFs). GEFs cause the release of GDP, allowing GDP to bind and Rac1 to become activated. GTPase-activated proteins (GAPs) down regulate the activity of GEFs be stimulating the inactivation via binding of GDP to Rac1. Active Rac1 stimulates proteins (ie. Wiskott–Aldrich syndrome) leading to actin polymerization. Actin polymerization is also regulated by cofilin. PAK proteins are critical effectors to cytoskeleton reorganization. PAK1 phosphorylates and activates LIM kinase. LIM kinase then phosphorylates cofilin, inactivating it leading to reduced actin filament severing and depolymerization, therby increasing polymerized actin. Rac1 stimulates lamellipodia and filopodia formation which are involved in cell movement and sensing the environment. It is proposed that PAK1 is involved in the phosphorylation of myosin light chain affecting myosin light chain phosphorylation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 14, 2018 at 17:46 Last Updated: September 14, 2018 at 17:46
PW122146 View Pathway	protein Rac 1 Cell Motility Signaling Pathway Bos taurus Rac1 is signaling protein part of the Rho GTPase family it is involved in cell motility, cell growth and cytoskeletal reorganization. Rac1 activity is regulated by guanine nucleotide exchange factors (GEFs). GEFs cause the release of GDP, allowing GDP to bind and Rac1 to become activated. GTPase-activated proteins (GAPs) down regulate the activity of GEFs be stimulating the inactivation via binding of GDP to Rac1. Active Rac1 stimulates proteins (ie. Wiskott–Aldrich syndrome) leading to actin polymerization. Actin polymerization is also regulated by cofilin. PAK proteins are critical effectors to cytoskeleton reorganization. PAK1 phosphorylates and activates LIM kinase. LIM kinase then phosphorylates cofilin, inactivating it leading to reduced actin filament severing and depolymerization, therby increasing polymerized actin. Rac1 stimulates lamellipodia and filopodia formation which are involved in cell movement and sensing the environment. It is proposed that PAK1 is involved in the phosphorylation of myosin light chain affecting myosin light chain phosphorylation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 14, 2018 at 17:47 Last Updated: September 14, 2018 at 17:47
PW101527 View Pathway	signaling Rac 1 cell motility signaling pathway Rattus norvegicus Rac1 is signaling protein part of the Rho GTPase family it is involved in cell motility, cell growth and cytoskeletal reorganization. Rac1 activity is regulated by guanine nucleotide exchange factors (GEFs). GEFs cause the release of GDP, allowing GDP to bind and Rac1 to become activated. GTPase-activated proteins (GAPs) down regulate the activity of GEFs be stimulating the inactivation via binding of GDP to Rac1. Active Rac1 stimulates proteins (ie. Wiskott–Aldrich syndrome) leading to actin polymerization. Actin polymerization is also regulated by cofilin. PAK proteins are critical effectors to cytoskeleton reorganization. PAK1 phosphorylates and activates LIM kinase. LIM kinase then phosphorylates cofilin, inactivating it leading to reduced actin filament severing and depolymerization, therby increasing polymerized actin. Rac1 stimulates lamellipodia and filopodia formation which are involved in cell movement and sensing the environment. It is proposed that PAK1 is involved in the phosphorylation of myosin light chain affecting myosin light chain phosphorylation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 23, 2018 at 12:26 Last Updated: August 23, 2018 at 12:26
PW101497 View Pathway	signaling Rac 1 cell motility signaling pathway Mus musculus Rac1 is signaling protein part of the Rho GTPase family it is involved in cell motility, cell growth and cytoskeletal reorganization. Rac1 activity is regulated by guanine nucleotide exchange factors (GEFs). GEFs cause the release of GDP, allowing GDP to bind and Rac1 to become activated. GTPase-activated proteins (GAPs) down regulate the activity of GEFs be stimulating the inactivation via binding of GDP to Rac1. Active Rac1 stimulates proteins (ie. Wiskott–Aldrich syndrome) leading to actin polymerization. Actin polymerization is also regulated by cofilin. PAK proteins are critical effectors to cytoskeleton reorganization. PAK1 phosphorylates and activates LIM kinase. LIM kinase then phosphorylates cofilin, inactivating it leading to reduced actin filament severing and depolymerization, therby increasing polymerized actin. Rac1 stimulates lamellipodia and filopodia formation which are involved in cell movement and sensing the environment. It is proposed that PAK1 is involved in the phosphorylation of myosin light chain affecting myosin light chain phosphorylation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 23, 2018 at 12:20 Last Updated: August 23, 2018 at 12:20
PW101512 View Pathway	signaling Rac 1 cell motility signaling pathway Bos taurus Rac1 is signaling protein part of the Rho GTPase family it is involved in cell motility, cell growth and cytoskeletal reorganization. Rac1 activity is regulated by guanine nucleotide exchange factors (GEFs). GEFs cause the release of GDP, allowing GDP to bind and Rac1 to become activated. GTPase-activated proteins (GAPs) down regulate the activity of GEFs be stimulating the inactivation via binding of GDP to Rac1. Active Rac1 stimulates proteins (ie. Wiskott–Aldrich syndrome) leading to actin polymerization. Actin polymerization is also regulated by cofilin. PAK proteins are critical effectors to cytoskeleton reorganization. PAK1 phosphorylates and activates LIM kinase. LIM kinase then phosphorylates cofilin, inactivating it leading to reduced actin filament severing and depolymerization, therby increasing polymerized actin. Rac1 stimulates lamellipodia and filopodia formation which are involved in cell movement and sensing the environment. It is proposed that PAK1 is involved in the phosphorylation of myosin light chain affecting myosin light chain phosphorylation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 23, 2018 at 12:23 Last Updated: August 23, 2018 at 12:23
PW146721 View Pathway	drug action Racemethionine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:52 Last Updated: October 07, 2023 at 18:52
PW146886 View Pathway	drug action Racephedrine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:17 Last Updated: October 07, 2023 at 19:17
PW128095 View Pathway	drug action Racepinephrine A1-Adrenergic Vasoconstriction Action Pathway Homo sapiens Racepinephrine is a bronchodilator used to treat asthma. It can be found under the brand name Asthmanefrin and is orally inhaled to act on both alpha and beta adrenergic receptors. This drug has a rapid onset and short duration and acts as a smooth muscle relaxant and constrictor in different tissues. It is a beta-2 adrenergic receptor agonist which allows for the activation of adenylyl cyclase to relax the smooth muscle of the lungs, and it is also an alpha-1 adrenergic receptor agonist which causes smooth muscle constriction of arterioles. Constricting the pre capillary arterioles reduces the hydrostatic pressure and consequently bronchial mucosal edema. Racepinephrine is a racemic mixture consisting of d-Epinephrine and l-Epinephrine enantiomers. Epinephrine is a non-selective α- and β-adrenergic receptor agonist. Epinephrine also activates alpha 1A adrenergic receptors in blood vessels. Alpha 1A adrenergic receptor is coupled to Gq signaling pathway, therefore, activation of alpha 1A receptors leads to activation of protein kinase C and opening of IP3 receptors on the endoplasmic reticulum which increases intracellular calcium. Calcium is necessary for muscle contraction; thus, administration of epinephrine minimizes the vasodilation and increased the vascular permeability that occurs during anaphylaxis. Side effects of using racepinephrine may include blurred vision, chest pain, and difficulty speaking. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: July 17, 2023 at 12:57 Last Updated: July 17, 2023 at 12:57