PathWhiz

PathWhiz ID	Pathway	Meta Data
PW012857 View Pathway	metabolic TCA Cycle2 Escherichia coli (strain K12) The citric acid cycle, which is also known as the tricarboxylic acid (TCA) cycle or the Krebs cycle, is a collection of 9 enzyme-catalyzed chemical reactions that occurs in all living cells undergoing aerobic respiration. The citric acid cycle itself was officially identified in 1937 by Hans Adolf Krebs, who received the Nobel Prize for this discovery in 1953. In eukaryotes, the citric acid cycle occurs in the mitochondria. In prokaryotes, the TCA cycle occurs in the cytoplasm. The TCA cycle starts with acetyl-CoA, which is the “fuel” for the entire cycle. This important molecule is formed from the breakdown of glycogen (a stored form of glucose), fats, and many amino acids. At the start of the cycle, acetyl-CoA first transfers its 2-carbon acetyl group to the 4-carbon acceptor compound called oxaloacetate to form the 6-carbon compound (citrate) for which the cycle is named. The resulting citrate molecule then goes through a series of chemical transformations, whereby it loses one carboxyl group (leading to the 5-carbon compound called alpha-ketoglutarate) and then a second carboxyl group (leading to the 4-carbon compound called succinate). Succinate molecule is further oxidized to fumarate, then malate and finally oxaloacetate. The regeneration of the 4-carbon oxaloacetate, allows the TCA cycle to continue. Most of the energy generated by the oxidation steps in the TCA cycle is transferred as energy-rich electrons to NAD+, forming NADH. For each acetyl group that enters the citric acid cycle, three molecules of NADH are produced. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: October 24, 2016 at 10:43 Last Updated: October 24, 2016 at 10:43
PW123645 View Pathway	metabolic TCA Klebsiella Klebsiella pneumoniae The TCA pathway is a catabolic pathway of aerobic respiration. It generates energy and reducing power. It is the first step in generating precursors for biosynthesis. When acetate is the carbon source, citrate synthase is rate-limiting for the TCA cycle BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: November 09, 2019 at 13:56 Last Updated: November 09, 2019 at 13:56
PW132218 View Pathway	metabolic Technetium Tc-99m disofenin Drug Metabolism Homo sapiens Technetium Tc-99m disofenin is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Technetium Tc-99m disofenin passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:12 Last Updated: September 21, 2023 at 20:12
PW146028 View Pathway	drug action Technetium Tc-99m disofenin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:14 Last Updated: October 07, 2023 at 17:14
PW132190 View Pathway	metabolic Technetium Tc-99m etidronate Drug Metabolism Homo sapiens Technetium Tc-99m etidronate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Technetium Tc-99m etidronate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:01 Last Updated: September 21, 2023 at 20:01
PW146143 View Pathway	drug action Technetium Tc-99m etidronate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:30 Last Updated: October 07, 2023 at 17:30
PW146027 View Pathway	drug action Technetium Tc-99m exametazime Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:14 Last Updated: October 07, 2023 at 17:14
PW132189 View Pathway	metabolic Technetium Tc-99m mebrofenin Drug Metabolism Homo sapiens Technetium Tc-99m mebrofenin is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Technetium Tc-99m mebrofenin passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:01 Last Updated: September 21, 2023 at 20:01
PW146006 View Pathway	drug action Technetium Tc-99m mebrofenin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:10 Last Updated: October 07, 2023 at 17:10
PW132180 View Pathway	metabolic Technetium Tc-99m medronate Drug Metabolism Homo sapiens Technetium Tc-99m medronate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Technetium Tc-99m medronate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 19:58 Last Updated: September 21, 2023 at 19:58