PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176354 View Pathway	metabolic Pretomanid Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:28 Last Updated: December 07, 2023 at 15:28
PW126541 View Pathway	drug action Prilocaine Homo sapiens Prilocaine is an local anesthetic that is similar to lidocaine often used most commonly for dental procedures. Prilocaine acts by binding to the intracellular surface of the sodium channels which blocks the influx of sodium into the cell. Due to this block of sodium ions this prevents the generation and propagation of action potential. This reverses when the drug diffuses out of the cell and is excreted from the body, allowing the sodium channel to function as it normally would and continue to generate action potential. Prilocaine is metabolized by the liver and kidney and is excreted by the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: January 09, 2022 at 20:38 Last Updated: January 09, 2022 at 20:38
PW000407 View Pathway	drug action Prilocaine Action Pathway Homo sapiens Prilocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Prilocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. For this to happen, the sodium channel must first become active so that so that gating mechanism is in the open state. Therefore prilocaine preferentially inhibits neurons that are actively firing. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW144861 View Pathway	drug action Prilocaine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:35 Last Updated: October 07, 2023 at 14:35
PW127442 View Pathway	drug action Primaquine Action Pathway Plasmodium falciparum Primaquine is an minoquinoline antimalarial is a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. It is the essential co-drug with chloroquine in treating all cases of malaria. In the blood, malaria parasites break down a part of the red blood cells known as haemoglobin. When this happens haemoglobin is divided into two parts; haem and globin. Haem is toxic to the malaria parasite. To prevent it from being damaged, the malaria parasite produces an chemical which converts the toxic haem into a non-toxic product. Primaquine acts by interfering with a part of the parasite (mitochondria) that is responsible for supplying it with energy. Without energy the parasite dies. Primaquine's mechanism of action is not well understood. It may be acting by generating reactive oxygen species or by interfering with the electron transport in the parasite. Also, although its mechanism of action is unclear, primaquine may bind to and alter the properties of protozoal DNA. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: February 09, 2023 at 12:17 Last Updated: February 09, 2023 at 12:17
PW145178 View Pathway	drug action Primaquine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:15 Last Updated: October 07, 2023 at 15:15
PW176527 View Pathway	metabolic Primaquine Predicted Metabolism Pathway Homo sapiens Metabolites of Primaquine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 13, 2023 at 14:05 Last Updated: December 13, 2023 at 14:05
PW121878 View Pathway	disease Primary Hyperoxaluria II, PH2 Mus musculus Primary hyperolaria type 2 (PH2) is a rare condition resulting from glyoxylate reductase/hydroxypyruvate reductase (GR/HPR) enzyme deficiency. PH2 results in calcium oxalate (also known as oxalic acid) deposits and end-stage renal disease. These deposits may cause kidney damage or failure. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:50 Last Updated: September 10, 2018 at 15:50
PW127340 View Pathway	disease Primary Hyperoxaluria II, PH2 Homo sapiens Primary hyperolaria type 2 (PH2) is a rare condition resulting from glyoxylate reductase/hydroxypyruvate reductase (GR/HPR) enzyme deficiency. PH2 results in calcium oxalate (also known as oxalic acid) deposits and end-stage renal disease. These deposits may cause kidney damage or failure. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: December 13, 2022 at 11:13 Last Updated: December 13, 2022 at 11:13
PW122102 View Pathway	disease Primary Hyperoxaluria II, PH2 Rattus norvegicus Primary hyperolaria type 2 (PH2) is a rare condition resulting from glyoxylate reductase/hydroxypyruvate reductase (GR/HPR) enzyme deficiency. PH2 results in calcium oxalate (also known as oxalic acid) deposits and end-stage renal disease. These deposits may cause kidney damage or failure. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:52 Last Updated: September 10, 2018 at 15:52