PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128624 View Pathway	drug action Sibutramine Dopamine Reuptake Inhibitor Action Pathway Homo sapiens Sibutramine, commonly known as Meridia or Reductil, is a norepinephrine, serotonin and dopamine reuptake inhibitor used for the treatment of obesity. This drug was withdrawn from US and Canadian markets for increased risk of heart attack and stroke in patients with heart disease history. Sibutramine stimulates the nervous system through the reuptake of norepinephrine, serotonin and dopamine, which prolongs their duration in the synapse so that they can bind more readily to the receptors. The mechanism is not fully understood, but may be similar to other dopamine reuptake inhibitors where Sibutramine would cross the blood-brain barrier through diffusion. Dopamine is synthesized in the ventral tegmental area of the brain from tyrosine being synthesized into L-dopa by the enzyme Tyrosine 3-monooxygenase . L-Dopa is then synthesized into dopamine with the enzyme aromatic-L-amino-acid decarboxylase. Dopamine then travels to the prefrontal cortex, which is released into the synapse when the neuron is stimulated and fires. Sibutramine binds to the sodium-dependent dopamine transporter, preventing dopamine from re-entering the presynaptic neuron. The dopamine then binds to Dopamine D4 receptors on the postsynaptic membrane. The dopamine D4 receptor activates the Gi protein cascade, which inhibits adenylate cyclase. This prevents adenylate cyclase from catalyzing ATP into cAMP. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ashley Zubkowski Created On: September 06, 2023 at 17:45 Last Updated: September 06, 2023 at 17:45
PW145194 View Pathway	drug action Sibutramine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:16 Last Updated: October 07, 2023 at 15:16
PW176231 View Pathway	metabolic Sibutramine Predicted Metabolism Pathway Homo sapiens Metabolites of Sibutramine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 12:59 Last Updated: December 04, 2023 at 12:59
PW064707 View Pathway	signaling Sigma B Activation Bacteria BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: March 29, 2018 at 01:42 Last Updated: March 29, 2018 at 01:42
PW146361 View Pathway	drug action Silanol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:01 Last Updated: October 07, 2023 at 18:01
PW126170 View Pathway	drug action Sildenafil Action Pathway Homo sapiens Sildenafil is a phosphodiesterase-5 inhibitor used for the treatment of erectile dysfunction. Sexual stimulation causes the release of nitric oxide (NO) from nerves and endothelial cells into the penis. NO activates the enzyme guanylate cyclase.2 The activation of this enzyme is followed by the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP), activating a cascade of protein kinase-dependent phosphorylation events in smooth muscles, ultimately resulting in the dephosphorylation of myosin light chains within smooth muscle. This activity causes the relaxation of smooth muscle within blood vessels, resulting in the desired vasodilatory effect. Phosphodiesterase-5 breaks down cGMP to GMP. Sildenafil inhibits phosphodiesterase-5, preventing the breakdown of cGMP. This increases the concentration of cGMP, increasing the vasodilation and improving blood flow leading to penile erection. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: July 28, 2021 at 23:48 Last Updated: July 28, 2021 at 23:48
PW144334 View Pathway	drug action Sildenafil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:25 Last Updated: October 07, 2023 at 13:25
PW175936 View Pathway	metabolic Sildenafil Predicted Metabolism Pathway Homo sapiens Sildenafil PIS1M1, Sildenafil PIS1M2, Sildenafil PIS2M1 are metabolites of Sildenafil predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 16, 2023 at 12:44 Last Updated: November 16, 2023 at 12:44
PW146253 View Pathway	drug action Silicon dioxide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:47 Last Updated: October 07, 2023 at 17:47
PW146576 View Pathway	drug action Silicon Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:33 Last Updated: October 07, 2023 at 18:33