PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176804 View Pathway	drug action Rupatadine H1-Antihistamine Immune Response Action Pathway Homo sapiens Rupatadine is a selective histamine H1 receptor antagonist and platelet activating factor (PAF) antagonist used to treat allergic rhinitis. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit the immune response, in blood vessels to constrict dilated blood vessels, and in smooth muscles of lungs and intestines to relax those muscles. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors. Furthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release. First-generation antihistamines readily cross the blood-brain barrier and cause sedation and other adverse central nervous system (CNS) effects (e.g. nervousness and insomnia). Second-generation antihistamines are more selective for H1-receptors of the peripheral nervous system (PNS) and do not cross the blood-brain barrier. Consequently, these newer drugs elicit fewer adverse drug reactions. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: December 19, 2023 at 15:09 Last Updated: December 19, 2023 at 15:09
PW176469 View Pathway	metabolic Rupatadine Predicted Metabolism Pathway Homo sapiens Metabolites of Rupatadine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 12, 2023 at 15:33 Last Updated: December 12, 2023 at 15:33
PW124214 View Pathway	metabolic Ruta Acinetobacter baumannii BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Johan Created On: October 13, 2020 at 17:30 Last Updated: October 13, 2020 at 17:30
PW124210 View Pathway	metabolic Ruta Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valentina Bustos Manrique Created On: October 12, 2020 at 09:00 Last Updated: October 12, 2020 at 09:00
PW124205 View Pathway	metabolic Ruta metabólica Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valentina Bustos Manrique Created On: October 11, 2020 at 17:55 Last Updated: October 11, 2020 at 17:55
PW124204 View Pathway	metabolic Ruta metabólica Homosapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valentina Bustos Manrique Created On: October 11, 2020 at 17:51 Last Updated: October 11, 2020 at 17:51
PW125946 View Pathway	metabolic Ruta metabólica de la síntesis de los ácidos grasos human La síntesis de ácidos grasos incluye la condensación de unidades de dos carbonos bajo la forma de acetil-CoA para formar largas cadenas hidrocarbonadas en una serie de reacciones. El complejo sintasa de ácidos grasos lleva a cabo estas reacciones, que requieren NADPH como reductor. Los ácidos grasos están unidos en forma covalente a la proteína transportadora de acilo (ACP) durante su síntesis BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: April 30, 2021 at 20:21 Last Updated: April 30, 2021 at 20:21
PW124132 View Pathway	metabolic rutas Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: August 28, 2020 at 00:28 Last Updated: August 28, 2020 at 00:28
PW124130 View Pathway	metabolic Rutas alimentadoras Acinetobacter baumannii BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: August 27, 2020 at 13:24 Last Updated: August 27, 2020 at 13:24
PW126067 View Pathway	metabolic rutas metabolicas Homo sapiens 123sdsf BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: June 08, 2021 at 16:58 Last Updated: June 08, 2021 at 16:58