PathWhiz

PathWhiz ID	Pathway	Meta Data
PW123933 View Pathway	metabolic Terpenoid Backbone Biosynthesis Drosophila melanogaster From glycolysis and the mevalonate pathway, diphosphomevalonic acid can be reacted with ATP to produce isopentenyl diphosphate which can be used in many reactions due to it's phosphate groups. Isopentenyl can be converted into geranyl pyrophosphate through two different paths, with one having an intermediate of dimethylallylpyrophosphate. Geranyl pyrophosphate itself can be used in monoterpenoid biosynthesis but more importantly, it can converted into (E,E)- farnesyl diphosphate through farnesyl pyrophosphate synthase. With (E,E)-farnesyl diphosphate and isopentenyl diphosphate, many reactions can take place depending on the number of substrates are used and how many phosphate groups are to be transferred. The products from the reactions are usually substrates for other biosynthesis pathways like N-glycan biosynthesis, carotenoid biosynthesis, diterpenoid biosynthesis, steroid biosynthesis and ubiquinone and other terpenoid quinone biosynthesis pathways. (E,E) farnesyl diphosphate can also be combined with a cysteine protein to make S-farnesyl protein. S-Farnesyl protein can have the c-terminal removed and then can be trans methylated by S-adenosylmethionine to eventually make farnesylcysteine. Through unknown processes farnesylcysteine can be converted can converted back to (E,E) farnesyl diphosphate, but not all the enzymes are known yet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Kristen Yee Created On: June 15, 2020 at 10:39 Last Updated: June 15, 2020 at 10:39
PW002485 View Pathway	metabolic Terpenoid Backbone Biosynthesis Saccharomyces cerevisiae The biosynthesis of steroids begins with acetyl coa being turned into acetoacetyl through a acetoacetyl CoA thiolase. Acetoacetyl -CoA reacts with an acetyl-CoA and water through a 3-hydroxy 3-methylglutaryl coenzyme A synthase resulting in the release of coenzyme A, hydrogen ion and (S)-3-hydroxy-3-methylglutaryl-CoA. The latter compound reacts with NADPH and a hydrogen ion through a 3-hydroxy-3-methylglutaryl-coenzyme A resulting in the release of coenzyme A , NADP and mevalonate. Mevalonate is then phosphorylated through an ATP driven kinase mevalonate kinase resulting in the release of ADP, hydrogen ion and mevalonate 5-phosphate. The latter compound is phosphorylated through an ATP driven kinase, phosphomevalonate kinase resulting in the release of ADP and mevalonate diphosphate. This latter compound then reacts with an ATP driven mevalonate diphosphate decarboxylase resulting in the release of ADP, carbon dioxide, a phosphate and a isopentenyl diphosphate. The latter compound can be isomerized into dimethylallyl diphosphate or reacth with a dimethylallyl diphosphate to produce geranyl diphosphate. Geranyl diphosphate reacts with a isopentenyl through a farnesyl diphosphate synthase resulting in the release of diphosphate and farnesyl diphosphate. Farnesyl diphosphate has three different fates: 1.-Producing hexaprenyl diphosphate in the mitocondrial inner membrane by reacting with 3 isopentenyl diphosphate 2.-Producing geranylgeranyl diphosphate in the cytoplasm by reacting with one isopentenyl diphosphate 3.-Producing a dolichol precursor in the ER by reacting with 13 isopentenyl diphosphates. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: February 25, 2016 at 11:11 Last Updated: February 25, 2016 at 11:11
PW122261 View Pathway	metabolic Terpenoid Backbone Biosynthesis 1540198538 Saccharomyces cerevisiae The biosynthesis of steroids begins with acetyl coa being turned into acetoacetyl through a acetoacetyl CoA thiolase. Acetoacetyl -CoA reacts with an acetyl-CoA and water through a 3-hydroxy 3-methylglutaryl coenzyme A synthase resulting in the release of coenzyme A, hydrogen ion and (S)-3-hydroxy-3-methylglutaryl-CoA. The latter compound reacts with NADPH and a hydrogen ion through a 3-hydroxy-3-methylglutaryl-coenzyme A resulting in the release of coenzyme A , NADP and mevalonate. Mevalonate is then phosphorylated through an ATP driven kinase mevalonate kinase resulting in the release of ADP, hydrogen ion and mevalonate 5-phosphate. The latter compound is phosphorylated through an ATP driven kinase, phosphomevalonate kinase resulting in the release of ADP and mevalonate diphosphate. This latter compound then reacts with an ATP driven mevalonate diphosphate decarboxylase resulting in the release of ADP, carbon dioxide, a phosphate and a isopentenyl diphosphate. The latter compound can be isomerized into dimethylallyl diphosphate or reacth with a dimethylallyl diphosphate to produce geranyl diphosphate. Geranyl diphosphate reacts with a isopentenyl through a farnesyl diphosphate synthase resulting in the release of diphosphate and farnesyl diphosphate. Farnesyl diphosphate has three different fates: 1.-Producing hexaprenyl diphosphate in the mitocondrial inner membrane by reacting with 3 isopentenyl diphosphate 2.-Producing geranylgeranyl diphosphate in the cytoplasm by reacting with one isopentenyl diphosphate 3.-Producing a dolichol precursor in the ER by reacting with 13 isopentenyl diphosphates. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: October 22, 2018 at 02:55 Last Updated: October 22, 2018 at 02:55
PW132264 View Pathway	metabolic Terpin hydrate Drug Metabolism Homo sapiens Terpin hydrate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Terpin hydrate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:28 Last Updated: September 21, 2023 at 20:28
PW146598 View Pathway	drug action Terpin hydrate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:36 Last Updated: October 07, 2023 at 18:36
PW000996 View Pathway	signaling Test Homo sapiens Testing Pathwhiz BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: July 28, 2015 at 07:14 Last Updated: July 28, 2015 at 07:14
PW122370 View Pathway	signaling Test Test BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: March 10, 2019 at 20:20 Last Updated: March 10, 2019 at 20:20
PW027313 View Pathway	metabolic test Bos taurus BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: June 15, 2017 at 22:20 Last Updated: June 15, 2017 at 22:20
PW123970 View Pathway	signaling test Mus musculus BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: 1169299218@qq.com Created On: July 08, 2020 at 03:51 Last Updated: July 08, 2020 at 03:51
PW012872 View Pathway	metabolic Test Arabidopsis thaliana BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: January 29, 2017 at 18:34 Last Updated: January 29, 2017 at 18:34