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PathWhiz ID	Pathway	Meta Data
PW124227 View Pathway	metabolic biosíntesis de pirimidinas Homo sapiens Estas bases son de crucial importancia debido a que su secuenciación en el ADN y el ARN, es la forma en que se almacena la información. Las letras que forman los codones en el código genético son la A, C, U, y G de las bases.http://hyperphysics.phy-astr.gsu.edu/hbasees/Organic/base.html BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: DINORA MARINA LEÓN GUTIÉRREZ Created On: October 15, 2020 at 19:35 Last Updated: October 15, 2020 at 19:35
PW124314 View Pathway	metabolic Biosíntesis de colesterol (error) Homo sapiens Síntesis de colesterol a partir de Acetil-CoA. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: November 06, 2020 at 20:15 Last Updated: November 06, 2020 at 20:15
PW124321 View Pathway	metabolic Biosíntesis de Colesterol (CV) Homo sapiens Biosíntesis de colesterol a partir de Acetil-CoA. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: November 06, 2020 at 21:41 Last Updated: November 06, 2020 at 21:41
PW124586 View Pathway	metabolic Biosíntesis de colesterol human BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Becerril Created On: March 17, 2021 at 22:30 Last Updated: March 17, 2021 at 22:30
PW002404 View Pathway	metabolic Biosynthesis of Unsaturated Fatty Acids (Tetracosanoyl-CoA) Saccharomyces cerevisiae The biosynthesis of unsaturated fatty acids begins with palmitic acid interacting with ATP and Coenzyme A through an acyl-CoA synthetase resulting in the release of AMP, diphosphate and palmitoyl-CoA. This compound then enters the cycle of unsaturated fatty acid elongation This cycle starts with the acyl-CoA reacting with a hydrogen ion and a malonyl-CoA through a 3-oxo-stearoyl-CoA synthase resulting in the release of a coenzyme A, a carbon dioxide molecule and a 3-oxoacyl-CoA. The 3-oxoacyl-CoA then reacts with a hydrogen ion and an NADPH through a 3-oxoacyl-CoA reductase resulting in the release of an NADP and a (3R)-3-hydroxy-acyl-CoA. The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. This compound then reacts with a hydrogen ion and a NADPH through a enoyl-CoA reductase resulting in the release of a NADP and a new acyl-CoA. The cycle goes from palmitoyl-CoA-->stearoyl-CoA-->eicosanoyl-CoA-->docosanoyl-CoA-->tetracosanoyl-CoA-->hexacosanoyl-CoA. The long chain fatty acids are then incorporated into the sphingolipid pathway. The long chain fatty acid reacts with a phytosphingosine through a ceramide synthase resulting in the release of a hydrogen ion, a coenzyme A and a N-acyl-phytosphinganine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: January 12, 2016 at 11:33 Last Updated: January 12, 2016 at 11:33
PW002435 View Pathway	metabolic Biosynthesis of Unsaturated Fatty Acids (Stearoyl-CoA) Saccharomyces cerevisiae The biosynthesis of unsaturated fatty acids begins with palmitic acid interacting with ATP and Coenzyme A through an acyl-CoA synthetase resulting in the release of AMP, diphosphate and palmitoyl-CoA. This compound then enters the cycle of unsaturated fatty acid elongation This cycle starts with the acyl-CoA reacting with a hydrogen ion and a malonyl-CoA through a 3-oxo-stearoyl-CoA synthase resulting in the release of a coenzyme A, a carbon dioxide molecule and a 3-oxoacyl-CoA. The 3-oxoacyl-CoA then reacts with a hydrogen ion and an NADPH through a 3-oxoacyl-CoA reductase resulting in the release of an NADP and a (3R)-3-hydroxy-acyl-CoA. The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. This compound then reacts with a hydrogen ion and a NADPH through a enoyl-CoA reductase resulting in the release of a NADP and a new acyl-CoA. The cycle goes from palmitoyl-CoA-->stearoyl-CoA-->eicosanoyl-CoA-->docosanoyl-CoA-->tetracosanoyl-CoA-->hexacosanoyl-CoA. The long chain fatty acids are then incorporated into the sphingolipid pathway. The long chain fatty acid reacts with a phytosphingosine through a ceramide synthase resulting in the release of a hydrogen ion, a coenzyme A and a N-acyl-phytosphinganine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: January 28, 2016 at 11:44 Last Updated: January 28, 2016 at 11:44
PW002434 View Pathway	metabolic Biosynthesis of Unsaturated Fatty Acids (Icosanoyl-CoA) Saccharomyces cerevisiae The biosynthesis of unsaturated fatty acids begins with palmitic acid interacting with ATP and Coenzyme A through an acyl-CoA synthetase resulting in the release of AMP, diphosphate and palmitoyl-CoA. This compound then enters the cycle of unsaturated fatty acid elongation This cycle starts with the acyl-CoA reacting with a hydrogen ion and a malonyl-CoA through a 3-oxo-stearoyl-CoA synthase resulting in the release of a coenzyme A, a carbon dioxide molecule and a 3-oxoacyl-CoA. The 3-oxoacyl-CoA then reacts with a hydrogen ion and an NADPH through a 3-oxoacyl-CoA reductase resulting in the release of an NADP and a (3R)-3-hydroxy-acyl-CoA. The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. This compound then reacts with a hydrogen ion and a NADPH through a enoyl-CoA reductase resulting in the release of a NADP and a new acyl-CoA. The cycle goes from palmitoyl-CoA-->stearoyl-CoA-->eicosanoyl-CoA-->docosanoyl-CoA-->tetracosanoyl-CoA-->hexacosanoyl-CoA. The long chain fatty acids are then incorporated into the sphingolipid pathway. The long chain fatty acid reacts with a phytosphingosine through a ceramide synthase resulting in the release of a hydrogen ion, a coenzyme A and a N-acyl-phytosphinganine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: January 28, 2016 at 10:17 Last Updated: January 28, 2016 at 10:17
PW002408 View Pathway	metabolic Biosynthesis of Unsaturated Fatty Acids (Docosanoyl-CoA) Saccharomyces cerevisiae The biosynthesis of unsaturated fatty acids begins with palmitic acid interacting with ATP and Coenzyme A through an acyl-CoA synthetase resulting in the release of AMP, diphosphate and palmitoyl-CoA. This compound then enters the cycle of unsaturated fatty acid elongation This cycle starts with the acyl-CoA reacting with a hydrogen ion and a malonyl-CoA through a 3-oxo-stearoyl-CoA synthase resulting in the release of a coenzyme A, a carbon dioxide molecule and a 3-oxoacyl-CoA. The 3-oxoacyl-CoA then reacts with a hydrogen ion and an NADPH through a 3-oxoacyl-CoA reductase resulting in the release of an NADP and a (3R)-3-hydroxy-acyl-CoA. The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. This compound then reacts with a hydrogen ion and a NADPH through a enoyl-CoA reductase resulting in the release of a NADP and a new acyl-CoA. The cycle goes from palmitoyl-CoA-->stearoyl-CoA-->eicosanoyl-CoA-->docosanoyl-CoA-->tetracosanoyl-CoA-->hexacosanoyl-CoA. The long chain fatty acids are then incorporated into the sphingolipid pathway. The long chain fatty acid reacts with a phytosphingosine through a ceramide synthase resulting in the release of a hydrogen ion, a coenzyme A and a N-acyl-phytosphinganine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: January 13, 2016 at 10:43 Last Updated: January 13, 2016 at 10:43
PW002403 View Pathway	metabolic Biosynthesis of Unsaturated Fatty Acids Saccharomyces cerevisiae The biosynthesis of unsaturated fatty acids begins with palmitic acid interacting with ATP and Coenzyme A through an acyl-CoA synthetase resulting in the release of AMP, diphosphate and palmitoyl-CoA. This compound then enters the cycle of unsaturated fatty acid elongation This cycle starts with the acyl-CoA reacting with a hydrogen ion and a malonyl-CoA through a 3-oxo-stearoyl-CoA synthase resulting in the release of a coenzyme A, a carbon dioxide molecule and a 3-oxoacyl-CoA. The 3-oxoacyl-CoA then reacts with a hydrogen ion and an NADPH through a 3-oxoacyl-CoA reductase resulting in the release of an NADP and a (3R)-3-hydroxy-acyl-CoA. The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. This compound then reacts with a hydrogen ion and an NADPH through an enoyl-CoA reductase resulting in the release of a NADP and a new acyl-CoA. The cycle goes from palmitoyl-CoA-->stearoyl-CoA-->eicosanoyl-CoA-->docosanoyl-CoA-->tetracosanoyl-CoA-->hexacosanoyl-CoA. The long-chain fatty acids are then incorporated into the sphingolipid pathway. The long-chain fatty acid reacts with a phytosphingosine through a ceramide synthase resulting in the release of a hydrogen ion, a coenzyme A, and an N-acyl-phytosphinganine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: January 07, 2016 at 16:14 Last Updated: January 07, 2016 at 16:14
PW123902 View Pathway	metabolic Biosynthesis of Type II Polyketide Products Streptomyces glaucescens Polyketides are a large group of bioactive secondary metabolites with various biological activities that arise from the diversity in its structures from the precursors of alternating groups like carbonyl and methylene. For this reason, they have a high value in pharmaceutical properties. They are primarily divided into three types: type I, type II and type III polyketides. This pathway focuses on the biosynthesis of type II polyketide products (from the biosynthesis of type II polyketide backbone) which are often based on aromatic molecules produced iteratively by the action of dissociated enzymes in the bacterial species Streptomyces glaucescens. This pathway shows the production of tetracenomycin C and 8-demethyl-tetracenomycin starting from 9,14-decaketides by the action of tcmI, tcmH, tcmN, tcmP, tcmG and tcmO gene proteins. Via a series of reactions using polyketide-synthase, hydroxylase and other enzymes shown in this illustration, the formation of tetracenomycin C occurs. It must be noted that 8-demethyl-tetracenomycin is a derivative of tetracenomycin-C (both shown to be stemming from tetracenomycin-B3) and acts as a teracenomycin having the similar bacterial metabolite role as tetracenomycin-C. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Aadhavya Sivakumaran Created On: May 29, 2020 at 11:35 Last Updated: May 29, 2020 at 11:35