PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145944 View Pathway	drug action Avibactam Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:01 Last Updated: October 07, 2023 at 17:01
PW252853 View Pathway	metabolic Avermectin B2a biosynthesis Streptomyces avermitilis Avermectin B2a biosynthesis involves several enzymatic reactions that convert simple precursors into a potent anthelmintic compound crucial for both bacterial metabolism and human medicine. The pathway starts with type I polyketide synthase (PKS) AVES 1, which elongates the carbon chain from 2-methylbutyryl-CoA, malonyl-CoA, and methylmalonyl-CoA to produce 6,8a-seco-6,8a-deoxy-5-oxoavermectin "2a" aglycone. This intermediate is then hydroxylated by cytochrome P450 hydroxylase to form 5-oxoavermectin "2a" aglycone, which is further reduced by C-5 ketoreductase to yield avermectin B2a aglycone. The addition of sugar moieties by glycosyltransferase enzymes, specifically dTDP-L-oleandrose transferase, completes the biosynthesis, resulting in avermectin B2a. This pathway is vital for as it provides a mechanism for producing bioactive compounds that can inhibit competing microorganisms. Additionally, avermectin B2a can be used in treating parasitic infections. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: May 27, 2024 at 09:46 Last Updated: May 27, 2024 at 09:46
PW251844 View Pathway	metabolic Avermectin A1a biosynthesis Streptomyces avermitilis Avermectin A1a biosynthesis involves multiple enzymatic steps that convert simple precursors like 2-methylbutyryl-CoA, malonyl-CoA, and methylmalonyl-CoA into the final potent anthelmintic compound. The process begins with chain elongation by type I polyketide synthase (PKS) AVES 1, forming 6,8a-seco-6,8a-deoxy-5-oxoavermectin "1a" aglycone. This intermediate is hydroxylated by cytochrome P450 hydroxylase, reduced by C-5 ketoreductase to avermectin B1a aglycone, and methylated by C5-O-methyltransferase to form avermectin A1a aglycone. Finally, glycosyltransferases add sugar moieties, resulting in avermectin A1a. This biosynthetic pathway yields aAvermectin A1a which has significant agricultural and medical applications as well as protecting bacteria from other competitive microorganisms. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: May 24, 2024 at 10:53 Last Updated: May 24, 2024 at 10:53
PW176242 View Pathway	metabolic Avatrombopag Predicted Metabolism Pathway Homo sapiens Metabolites of Avatrombopag are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 13:58 Last Updated: December 04, 2023 at 13:58
PW146483 View Pathway	drug action Avatrombopag Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:18 Last Updated: October 07, 2023 at 18:18
PW146909 View Pathway	drug action Avapritinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:20 Last Updated: October 07, 2023 at 19:20
PW132561 View Pathway	metabolic Avapritinib Drug Metabolism Homo sapiens Avapritinib is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Avapritinib passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:25 Last Updated: September 21, 2023 at 22:25
PW145691 View Pathway	drug action Avanafil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:24 Last Updated: October 07, 2023 at 16:24
PW175975 View Pathway	metabolic Avacopan Predicted Metabolism Pathway new Homo sapiens Metabolites of Avacopan are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 12:55 Last Updated: November 29, 2023 at 12:55
PW146903 View Pathway	drug action Avacopan Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:19 Last Updated: October 07, 2023 at 19:19