PathWhiz

PathWhiz ID	Pathway	Meta Data
PW292565 View Pathway	disease Virulence Pathway (virH operon activation) Agrobacterium tumefaciens str. C58 The virH operon is part of the broader virulence (vir) regulon that is essential for a bacterium's ability to transfer T-DNA to plant cells, causing crown gall disease. The virulence genes are typically located on the Ti (tumor-inducing) plasmid, and their expression is regulated in response to plant-derived signals. The bicistronic virH operon is composed of 2 genes - virH1 and virH2 whose proteins resemble those of the cytochrome P450-type mono-oxygenases family. Expression of this operon is induced by phenolic compounds e.g., acetosyringone (AS) and repressed by indole acetic acid (IAA) which acts as a competitive inhibitor of AS. This expression is controlled by virA which encodes for a transmembrane histidine protein kinase and virG which encodes a cytoplasmic response regulator. AS binds to transmembrane histidine protein kinase virA, resulting in phosphorylation of virG which then binds to the vir box (10 to 12bp sequences) in the promoter region and initiates transcription. VirH2 is reponsible for a O-demethylation reaction which converts ferulic acid (a plant phenolic defence compound) to caffeic acid, which is less toxic, thus facilitating pathogenicity. VirH1, sharing 20% identitiy to virH2, is also involved in metabolism of phenolic compounds, though different from those metabolized by virH2. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: August 27, 2024 at 17:24 Last Updated: August 27, 2024 at 17:24
PW091256 View Pathway	metabolic Visceral Fat Deposits and the Metabolic Syndrome Homo sapiens Although abdominal obesity or visceral obesity is considered to be one of the components of metabolic syndrome and to have an important role in a cluster of cardiovascular risks, there is no consensus about the definition and diagnostic criteria for this syndrome, probably because there is considerable disagreement about the location and definition of abdominal obesity or visceral obesity. The importance of diagnosing metabolic syndrome, in which visceral fat accumulation plays an essential role in the development of multiple risk factors, should be emphasized because lifestyle modification for the reduction of visceral fat may be very effective for the reduction of risks of this type, namely metabolic syndrome in the narrow sense. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Aidin Foroutannaddafi Created On: August 14, 2018 at 18:23 Last Updated: August 14, 2018 at 18:23
PW132533 View Pathway	metabolic Vismodegib Drug Metabolism Homo sapiens Vismodegib is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Vismodegib passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:17 Last Updated: September 21, 2023 at 22:17
PW145850 View Pathway	drug action Vismodegib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:49 Last Updated: October 07, 2023 at 16:49
PW121979 View Pathway	disease Vitamin A Deficiency Rattus norvegicus Vitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two substrates are beta-carotene and O2, whereas its product is retinal. A defect in this enzyme results in decrease of levels of retinal and vitamin A in serum; Signs and symptoms include night blindness, poor adaptation to darkness, dry skin and hair. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:51 Last Updated: September 10, 2018 at 15:51
PW000210 View Pathway	disease Vitamin A Deficiency Homo sapiens Vitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two substrates are beta-carotene and O2, whereas its product is retinal. A defect in this enzyme results in decrease of levels of retinal and vitamin A in serum; Signs and symptoms include night blindness, poor adaptation to darkness, dry skin and hair. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 19, 2013 at 12:05 Last Updated: August 19, 2013 at 12:05
PW121754 View Pathway	disease Vitamin A Deficiency Mus musculus Vitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two substrates are beta-carotene and O2, whereas its product is retinal. A defect in this enzyme results in decrease of levels of retinal and vitamin A in serum; Signs and symptoms include night blindness, poor adaptation to darkness, dry skin and hair. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:49 Last Updated: September 10, 2018 at 15:49
PW127355 View Pathway	disease Vitamin A Deficiency Homo sapiens Vitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two substrates are beta-carotene and O2, whereas its product is retinal. A defect in this enzyme results in decrease of levels of retinal and vitamin A in serum; Signs and symptoms include night blindness, poor adaptation to darkness, dry skin and hair. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: December 15, 2022 at 12:27 Last Updated: December 15, 2022 at 12:27
PW144298 View Pathway	drug action Vitamin A Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:20 Last Updated: October 07, 2023 at 13:20
PW000892 View Pathway	metabolic Vitamin B1/Thiamine Biosynthesis Escherichia coli (strain K12) BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: May 08, 2015 at 12:02 Last Updated: May 08, 2015 at 12:02