PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176472 View Pathway	metabolic Atazanavir Predicted Metabolism Pathway Homo sapiens Metabolites of Atazanavir are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 12, 2023 at 16:03 Last Updated: December 12, 2023 at 16:03
PW145163 View Pathway	drug action Atazanavir Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:12 Last Updated: October 07, 2023 at 15:12
PW127505 View Pathway	drug action Atazanavir Action Pathway Homo sapiens Atazanavir (formerly known as BMS-232632) is an antiretroviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV in adults and pediatric patients 3 months of age and older weighing at least 5kg. It is used in combination with cobicistat and other antiretrovirals. The HIV virus binds and penetrates the host cell. Viral RNA is transcribed into viral DNA via reverse transcriptase. Viral DNA enters the host nucleus and is integrated into the host DNA via integrase. The DNA is then transcribed, creating viral mRNA. Viral mRNA is translater into the gag-pol polyprotein. HIV protease is synthesized as part of the Gag-pol polyprotein, where Gag encodes for the capsid and matrix protein to form the outer protein shell, and Pol encodes for the reverse transcriptase and integrase protein to synthesize and incorporate its genome into host cells. HIV-1 protease cleaves the Gag-pol polyprotein into 66 molecular species, including HIV-1 protease, integrase, and reverse transcriptase. Atazanavir selectively inhibits HIV-1 protease. This inhibition prevents the HIV virion from fully maturing and becoming infective. Using the lipid bilayer of the host cell, a virus is formed and released. The inhibition of HIV-1 protease prevents the necessary molecular species from forming, therefore preventing maturation and activation of viral particles. This forms immature, non-infectious viral particles, therefore, Atazanavir prevents the virus from reproducing. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: March 22, 2023 at 15:13 Last Updated: March 22, 2023 at 15:13
PW145624 View Pathway	drug action Ataluren Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:14 Last Updated: October 07, 2023 at 16:14
PW175974 View Pathway	metabolic Asunaprevir Predicted Metabolism Pathway new Homo sapiens Metabolites of Asunaprevir are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 12:55 Last Updated: November 29, 2023 at 12:55
PW146389 View Pathway	drug action Asunaprevir Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:05 Last Updated: October 07, 2023 at 18:05
PW127745 View Pathway	drug action Asunaprevir Action Pathway Hepatitis C virus Asunaprevir, also known as BMS-650032, is an NS3 protease inhibitor used to treat hepatitis C genotype 1b. It as been found to be highly effective in dual-combination regimens with daclatasvir in patients with chronic HCV genotype 1b. The lipoviroparticles attach to LDL-R and SR-B1, and then the virus binds to CD81 and subsequently claudin-1 and occludin, which mediate the late steps of viral entry. The virus is internalized by clathrin-dependent endocytosis. RNA is released from the mature Hepatitis C virion and translated at the rough endoplasmic reticulum into a single Genome polyprotein. Asunaprevir accumulates in the liver after uptake into hepatocytes via solute carrier organic anion transporter family member 1B1. Asunaprevir inhibits NS3 protease, which is an enzyme that cleaves the heptatitis C virus polyprotein downstream of the NS3 proteolytic site, which generates nonstructural proteins NS3, NS4A, NS4B, NS5A, and NS5B. These proteins are required in viral RNA replication, therefore because of the inhibition of their formation, RNA replication cannot occur. Because RNA replication does not occur, the mature virion is unable to form. At higher concentration above their antiviral half-maximal effective concentration (EC50), NS3 protease cleaves two essential adaptor proteins that initiate signaling leading to activation of IFN regulatory factor 3 and IFN-α/β synthesis, which are mitochondrial antiviral-signaling proteins. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: May 30, 2023 at 09:57 Last Updated: May 30, 2023 at 09:57
PW123658 View Pathway	metabolic Astrocytes Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: November 29, 2019 at 07:36 Last Updated: November 29, 2019 at 07:36
PW001864 View Pathway	disease Asthma pathophysiology 1441179207 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: September 02, 2015 at 01:35 Last Updated: September 02, 2015 at 01:35
PW001863 View Pathway	disease Asthma pathophysiology 1441179163 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: September 02, 2015 at 01:34 Last Updated: September 02, 2015 at 01:34