PathWhiz

PathWhiz ID	Pathway	Meta Data
PW409201 View Pathway	metabolic Threonine Biosynthesis Paraprevotella xylaniphila YIT 11841 The biosynthesis of threonine starts with oxalacetic acid interacting with an L-glutamic acid through an aspartate aminotransferase resulting in a oxoglutaric acid and an L-aspartic acid. The latter compound is then phosphorylated by an ATP driven Aspartate kinase resulting in an a release of an ADP and an L-aspartyl-4-phosphate. L-aspartyl-4-phosphate then interacts with a hydrogen ion through an NADPH driven aspartate semialdehyde dehydrogenase resulting in the release of a phosphate, an NADP and a L-aspartate-semialdehyde. The latter compound interacts with a hydrogen ion through a NADPH driven aspartate kinase / homoserine dehydrogenase resulting in the release of an NADP and a L-homoserine. L-homoserine is phosphorylated through an ATP driven homoserine kinase resulting in the release of an ADP, a hydrogen ion and a O-phosphohomoserine. O-phosphohomoserine then interacts with a water molecule and threonine synthase resulting in the release of a phosphate and an L-threonine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: December 23, 2024 at 10:45 Last Updated: December 23, 2024 at 10:45
PW410126 View Pathway	metabolic Threonine Biosynthesis Desulfovibrio sp. 3_1_syn3 The biosynthesis of threonine starts with oxalacetic acid interacting with an L-glutamic acid through an aspartate aminotransferase resulting in a oxoglutaric acid and an L-aspartic acid. The latter compound is then phosphorylated by an ATP driven Aspartate kinase resulting in an a release of an ADP and an L-aspartyl-4-phosphate. L-aspartyl-4-phosphate then interacts with a hydrogen ion through an NADPH driven aspartate semialdehyde dehydrogenase resulting in the release of a phosphate, an NADP and a L-aspartate-semialdehyde. The latter compound interacts with a hydrogen ion through a NADPH driven aspartate kinase / homoserine dehydrogenase resulting in the release of an NADP and a L-homoserine. L-homoserine is phosphorylated through an ATP driven homoserine kinase resulting in the release of an ADP, a hydrogen ion and a O-phosphohomoserine. O-phosphohomoserine then interacts with a water molecule and threonine synthase resulting in the release of a phosphate and an L-threonine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: December 23, 2024 at 17:48 Last Updated: December 23, 2024 at 17:48
PW410582 View Pathway	metabolic Threonine Biosynthesis Morganella morganii subsp. morganii KT The biosynthesis of threonine starts with oxalacetic acid interacting with an L-glutamic acid through an aspartate aminotransferase resulting in a oxoglutaric acid and an L-aspartic acid. The latter compound is then phosphorylated by an ATP driven Aspartate kinase resulting in an a release of an ADP and an L-aspartyl-4-phosphate. L-aspartyl-4-phosphate then interacts with a hydrogen ion through an NADPH driven aspartate semialdehyde dehydrogenase resulting in the release of a phosphate, an NADP and a L-aspartate-semialdehyde. The latter compound interacts with a hydrogen ion through a NADPH driven aspartate kinase / homoserine dehydrogenase resulting in the release of an NADP and a L-homoserine. L-homoserine is phosphorylated through an ATP driven homoserine kinase resulting in the release of an ADP, a hydrogen ion and a O-phosphohomoserine. O-phosphohomoserine then interacts with a water molecule and threonine synthase resulting in the release of a phosphate and an L-threonine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: December 23, 2024 at 21:18 Last Updated: December 23, 2024 at 21:18
PW410621 View Pathway	metabolic Threonine Biosynthesis Providencia rettgeri DSM 1131 The biosynthesis of threonine starts with oxalacetic acid interacting with an L-glutamic acid through an aspartate aminotransferase resulting in a oxoglutaric acid and an L-aspartic acid. The latter compound is then phosphorylated by an ATP driven Aspartate kinase resulting in an a release of an ADP and an L-aspartyl-4-phosphate. L-aspartyl-4-phosphate then interacts with a hydrogen ion through an NADPH driven aspartate semialdehyde dehydrogenase resulting in the release of a phosphate, an NADP and a L-aspartate-semialdehyde. The latter compound interacts with a hydrogen ion through a NADPH driven aspartate kinase / homoserine dehydrogenase resulting in the release of an NADP and a L-homoserine. L-homoserine is phosphorylated through an ATP driven homoserine kinase resulting in the release of an ADP, a hydrogen ion and a O-phosphohomoserine. O-phosphohomoserine then interacts with a water molecule and threonine synthase resulting in the release of a phosphate and an L-threonine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: December 23, 2024 at 21:38 Last Updated: December 23, 2024 at 21:38
PW413992 View Pathway	metabolic Threonine Biosynthesis Escherichia coli SE15 The biosynthesis of threonine starts with oxalacetic acid interacting with an L-glutamic acid through an aspartate aminotransferase resulting in a oxoglutaric acid and an L-aspartic acid. The latter compound is then phosphorylated by an ATP driven Aspartate kinase resulting in an a release of an ADP and an L-aspartyl-4-phosphate. L-aspartyl-4-phosphate then interacts with a hydrogen ion through an NADPH driven aspartate semialdehyde dehydrogenase resulting in the release of a phosphate, an NADP and a L-aspartate-semialdehyde. The latter compound interacts with a hydrogen ion through a NADPH driven aspartate kinase / homoserine dehydrogenase resulting in the release of an NADP and a L-homoserine. L-homoserine is phosphorylated through an ATP driven homoserine kinase resulting in the release of an ADP, a hydrogen ion and a O-phosphohomoserine. O-phosphohomoserine then interacts with a water molecule and threonine synthase resulting in the release of a phosphate and an L-threonine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: December 25, 2024 at 14:14 Last Updated: December 25, 2024 at 14:14
PW002401 View Pathway	metabolic Threonine Metabolism Saccharomyces cerevisiae The biosynthesis of threonine starts with L-aspartic acid being phosphorylated by an ATP-driven aspartate kinase resulting in a release of an ADP and an L-aspartyl-4-phosphate. This compound interacts with a hydrogen ion through an NADPH-driven aspartate semialdehyde dehydrogenase resulting in the release of a phosphate, an NADP, and an L-aspartate-semialdehyde. The latter compound interacts with a hydrogen ion through an NADPH-driven aspartate kinase / homoserine dehydrogenase resulting in the release of an NADP and an L-homoserine. L-Homoserine is phosphorylated through an ATP driven homoserine kinase resulting in the release of an ADP, a hydrogen ion, and an O-phosphohomoserine. The latter compound then interacts with a water molecule threonine synthase resulting in the release of a phosphate and an L-threonine. L-threonine is degraded into glycine and acetaldehyde by reacting with a threonine aldolase. Acetaldehyde can then be integrated into the mitochondria or stay in the cytosol. It is then degraded into acetyl-CoA through an aldehyde dehydrogenase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: January 07, 2016 at 10:05 Last Updated: January 07, 2016 at 10:05
PW002554 View Pathway	metabolic Threonine Metabolism Arabidopsis thaliana The biosynthesis of threonine starts with L-aspartic acid being phosphorylated by an ATP-driven aspartate kinase resulting in a release of an ADP and an L-aspartyl-4-phosphate. This compound interacts with a hydrogen ion through an NADPH-driven aspartate semialdehyde dehydrogenase resulting in the release of a phosphate, an NADP, and an L-aspartate-semialdehyde. The latter compound interacts with a hydrogen ion through an NADPH-driven aspartate kinase / homoserine dehydrogenase resulting in the release of an NADP and an L-homoserine. L-Homoserine is phosphorylated through an ATP driven homoserine kinase resulting in the release of an ADP, a hydrogen ion, and an O-phosphohomoserine. The latter compound then interacts with a water molecule threonine synthase resulting in the release of a phosphate and an L-threonine. L-threonine is degraded into glycine and acetaldehyde by reacting with a threonine aldolase. Acetaldehyde can then be integrated into the mitochondria or stay in the cytosol. It is then degraded into acetyl-CoA through an aldehyde dehydrogenase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: May 27, 2016 at 13:49 Last Updated: May 27, 2016 at 13:49
PW128498 View Pathway	drug action Thrombin Alfa Action Pathway Homo sapiens Thrombin alfa also known under the brand name Recothrom, is a platelet-activating factor to treat minor bleeding. It is administered topically, it is a recombinant thrombin identical to that of the endogenous human thrombin. Thrombin alfa is a human serine protease that cleaves fibrinogen to fibrin which leads to clot formation. Once thrombin alfa has performed its function it is rapidly inactivated by circulating endogenous plasma inhibitors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 31, 2023 at 17:51 Last Updated: August 31, 2023 at 17:51
PW128496 View Pathway	drug action Thrombin Alfa Action Pathway (didnt work) Homo sapiens Thrombin alfa also known under the brand name Recothrom, is a platelet-activating factor to treat minor bleeding. It is administered topically, it is a recombinant thrombin identical to that of the endogenous human thrombin. Thrombin alfa is a human serine protease that cleaves fibrinogen to fibrin which leads to clot formation. Once thrombin alfa has performed its function it is rapidly inactivated by circulating endogenous plasma inhibitors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 31, 2023 at 17:28 Last Updated: August 31, 2023 at 17:28
PW129677 View Pathway	metabolic Thrombopoietin Drug Metabolism Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: September 14, 2023 at 19:26 Last Updated: September 14, 2023 at 19:26