PathWhiz

PathWhiz ID	Pathway	Meta Data
PW002529 View Pathway	metabolic Aspartate Metabolism Arabidopsis thaliana Aspartate is synthesized from oxaloacetic acid and l-glutamate in the cytosol, the chloroplast, the mitochondria and the peroxisome. Aspartate is broken down via conversion to malate, a part of the reversible malate-aspartate shuttle in the mitochondrial and cytoplasmic space. This shuttle involves the transfer of reduction equivalents across the mitochondrial membrane to produce ATP. NADH is unable to cross the inner mitochondrial membrane. Therefore, the shuttle allows electrons from NADH in the cytosol, a product of glycolysis, to cross the inner mitochondrial membrane to produce ATP. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: April 18, 2016 at 15:38 Last Updated: April 18, 2016 at 15:38
PW064572 View Pathway	metabolic Aspartate Metabolism Mus musculus Aspartate is synthesized by transamination of oxaloacetate by aspartate aminotransferase or amino acid oxidase. Aspartyl-tRNA synthetase can then couple aspartate to aspartyl tRNA for protein synthesis. The aspartate content in human proteins is about 7%. Asparagine synthase can convert aspartate to the polar amino acid asparagine. Aspartate is also a precursor for cellular signaling compounds such as, N-acetyl-aspartate, beta-alanine, adenylsuccinate, arginino-succinate and N-carbamoylaspartate. Aspartate is also a metabolite in the urea cycle and involved in gluconeogenesis. Additionally, aspartate carries the reducing equivalents in the mitochondrial malate-aspartate shuttle, which utilizes the ready interconversion of aspartate and oxaloacetate. The conjugate base of L-aspartic acid, aspartate, also acts as an excitatory neurotransmitter in the brain which activates NMDA receptors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: January 21, 2018 at 20:05 Last Updated: January 21, 2018 at 20:05
PW088445 View Pathway	metabolic Aspartate Metabolism Caenorhabditis elegans Aspartate is synthesized by transamination of oxaloacetate by aspartate aminotransferase or amino acid oxidase. Aspartyl-tRNA synthetase can then couple aspartate to aspartyl tRNA for protein synthesis. The aspartate content in human proteins is about 7%. Asparagine synthase can convert aspartate to the polar amino acid asparagine. Aspartate is also a precursor for cellular signaling compounds such as, N-acetyl-aspartate, beta-alanine, adenylsuccinate, arginino-succinate and N-carbamoylaspartate. Aspartate is also a metabolite in the urea cycle and involved in gluconeogenesis. Additionally, aspartate carries the reducing equivalents in the mitochondrial malate-aspartate shuttle, which utilizes the ready interconversion of aspartate and oxaloacetate. The conjugate base of L-aspartic acid, aspartate, also acts as an excitatory neurotransmitter in the brain which activates NMDA receptors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 16:49 Last Updated: August 10, 2018 at 16:49
PW396314 View Pathway	metabolic Aspartate Metabolism Escherichia coli O26:H11 str. 11368 Aspartate is synthesized from and broken down to oxaloacetate, a TCA cycle intermediate, via a reversible transamination reaction with glutamate. This reaction is catalyzed by the aminotransferase AspC or TyrB. Aspartate is a component of proteins and is involved in many biosyntheses pathways like NAD biosynthesis and beta-alanine metabolism. Aspartate can also be synthesized from fumaric acid through an aspartate ammonia lyase. Aspartate also participates in the synthesis of L-asparagine through two different methods, either through aspartate ammonia ligase or asparagine synthetase B. Aspartate is also a precursor of fumaric acid. Again it has two possible ways of synthesizing it. First set of reactions follows an adenylo succinate synthetase that yields adenylsuccinic acid and then adenylosuccinate lyase in turns leads to fumaric acid. The second way is through argininosuccinate synthase that yields argininosuccinic acid and then argininosuccinate lyase in turns leads to fumaric acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: December 16, 2024 at 16:01 Last Updated: December 16, 2024 at 16:01
PW390847 View Pathway	metabolic Aspartate Metabolism Aeromonas media WS Aspartate is synthesized from and broken down to oxaloacetate, a TCA cycle intermediate, via a reversible transamination reaction with glutamate. This reaction is catalyzed by the aminotransferase AspC or TyrB. Aspartate is a component of proteins and is involved in many biosyntheses pathways like NAD biosynthesis and beta-alanine metabolism. Aspartate can also be synthesized from fumaric acid through an aspartate ammonia lyase. Aspartate also participates in the synthesis of L-asparagine through two different methods, either through aspartate ammonia ligase or asparagine synthetase B. Aspartate is also a precursor of fumaric acid. Again it has two possible ways of synthesizing it. First set of reactions follows an adenylo succinate synthetase that yields adenylsuccinic acid and then adenylosuccinate lyase in turns leads to fumaric acid. The second way is through argininosuccinate synthase that yields argininosuccinic acid and then argininosuccinate lyase in turns leads to fumaric acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: December 13, 2024 at 11:23 Last Updated: December 13, 2024 at 11:23
PW390950 View Pathway	metabolic Aspartate Metabolism Arcobacter butzleri RM4018 Aspartate is synthesized from and broken down to oxaloacetate, a TCA cycle intermediate, via a reversible transamination reaction with glutamate. This reaction is catalyzed by the aminotransferase AspC or TyrB. Aspartate is a component of proteins and is involved in many biosyntheses pathways like NAD biosynthesis and beta-alanine metabolism. Aspartate can also be synthesized from fumaric acid through an aspartate ammonia lyase. Aspartate also participates in the synthesis of L-asparagine through two different methods, either through aspartate ammonia ligase or asparagine synthetase B. Aspartate is also a precursor of fumaric acid. Again it has two possible ways of synthesizing it. First set of reactions follows an adenylo succinate synthetase that yields adenylsuccinic acid and then adenylosuccinate lyase in turns leads to fumaric acid. The second way is through argininosuccinate synthase that yields argininosuccinic acid and then argininosuccinate lyase in turns leads to fumaric acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: December 13, 2024 at 12:44 Last Updated: December 13, 2024 at 12:44
PW684465 View Pathway	metabolic Aspartate Metabolism Bacteroides nordii CL02T12C05 Aspartate is synthesized from and broken down to oxaloacetate, a TCA cycle intermediate, via a reversible transamination reaction with glutamate. This reaction is catalyzed by the aminotransferase AspC or TyrB. Aspartate is a component of proteins and is involved in many biosyntheses pathways like NAD biosynthesis and beta-alanine metabolism. Aspartate can also be synthesized from fumaric acid through an aspartate ammonia lyase. Aspartate also participates in the synthesis of L-asparagine through two different methods, either through aspartate ammonia ligase or asparagine synthetase B. Aspartate is also a precursor of fumaric acid. Again it has two possible ways of synthesizing it. First set of reactions follows an adenylo succinate synthetase that yields adenylsuccinic acid and then adenylosuccinate lyase in turns leads to fumaric acid. The second way is through argininosuccinate synthase that yields argininosuccinic acid and then argininosuccinate lyase in turns leads to fumaric acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: December 14, 2024 at 02:26 Last Updated: December 14, 2024 at 02:26
PW394135 View Pathway	metabolic Aspartate Metabolism Sutterella parvirubra YIT 11816 Aspartate is synthesized from and broken down to oxaloacetate, a TCA cycle intermediate, via a reversible transamination reaction with glutamate. This reaction is catalyzed by the aminotransferase AspC or TyrB. Aspartate is a component of proteins and is involved in many biosyntheses pathways like NAD biosynthesis and beta-alanine metabolism. Aspartate can also be synthesized from fumaric acid through an aspartate ammonia lyase. Aspartate also participates in the synthesis of L-asparagine through two different methods, either through aspartate ammonia ligase or asparagine synthetase B. Aspartate is also a precursor of fumaric acid. Again it has two possible ways of synthesizing it. First set of reactions follows an adenylo succinate synthetase that yields adenylsuccinic acid and then adenylosuccinate lyase in turns leads to fumaric acid. The second way is through argininosuccinate synthase that yields argininosuccinic acid and then argininosuccinate lyase in turns leads to fumaric acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: December 14, 2024 at 11:48 Last Updated: December 14, 2024 at 11:48
PW684510 View Pathway	metabolic Aspartate Metabolism Morganella morganii subsp. morganii KT Aspartate is synthesized from and broken down to oxaloacetate, a TCA cycle intermediate, via a reversible transamination reaction with glutamate. This reaction is catalyzed by the aminotransferase AspC or TyrB. Aspartate is a component of proteins and is involved in many biosyntheses pathways like NAD biosynthesis and beta-alanine metabolism. Aspartate can also be synthesized from fumaric acid through an aspartate ammonia lyase. Aspartate also participates in the synthesis of L-asparagine through two different methods, either through aspartate ammonia ligase or asparagine synthetase B. Aspartate is also a precursor of fumaric acid. Again it has two possible ways of synthesizing it. First set of reactions follows an adenylo succinate synthetase that yields adenylsuccinic acid and then adenylosuccinate lyase in turns leads to fumaric acid. The second way is through argininosuccinate synthase that yields argininosuccinic acid and then argininosuccinate lyase in turns leads to fumaric acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: December 14, 2024 at 16:49 Last Updated: December 14, 2024 at 16:49
PW684504 View Pathway	metabolic Aspartate Metabolism Citrobacter amalonaticus Y19 Aspartate is synthesized from and broken down to oxaloacetate, a TCA cycle intermediate, via a reversible transamination reaction with glutamate. This reaction is catalyzed by the aminotransferase AspC or TyrB. Aspartate is a component of proteins and is involved in many biosyntheses pathways like NAD biosynthesis and beta-alanine metabolism. Aspartate can also be synthesized from fumaric acid through an aspartate ammonia lyase. Aspartate also participates in the synthesis of L-asparagine through two different methods, either through aspartate ammonia ligase or asparagine synthetase B. Aspartate is also a precursor of fumaric acid. Again it has two possible ways of synthesizing it. First set of reactions follows an adenylo succinate synthetase that yields adenylsuccinic acid and then adenylosuccinate lyase in turns leads to fumaric acid. The second way is through argininosuccinate synthase that yields argininosuccinic acid and then argininosuccinate lyase in turns leads to fumaric acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: December 14, 2024 at 15:09 Last Updated: December 14, 2024 at 15:09