PathWhiz

PathWhiz ID	Pathway	Meta Data
PW000137 View Pathway	drug action Alendronate Action Pathway Homo sapiens Alendronate (also known as alendronic acid) is a type of bisphosphonate medication with nitrogen that can inhibit FPP synthase, which can block the pathway that produce geranyl-PP and farnesyl pyrophosphate. Geranyl-PP and farnesyl pyrophosphate are the compounds that are required for small GTPase signalling proteins undergo post-translational farnesylation and geranylgeranylation. Therefore, lack the formation of geranyl-PP and farnesyl pyrophosphate can prevent osteoclast activity, which lead to prevention of reduced bone resorption and turnover. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 04, 2013 at 21:45 Last Updated: August 04, 2013 at 21:45
PW175965 View Pathway	metabolic Alectinib Predicted Metabolism Pathway new Homo sapiens Metabolites of Alectinib are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 12:51 Last Updated: November 29, 2023 at 12:51
PW146369 View Pathway	drug action Alectinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:02 Last Updated: October 07, 2023 at 18:02
PW122401 View Pathway	physiological Aldosterone from Steroidogenesis Homo sapiens Aldosterone is a hormone produced in the zona glomerulosa of the adrenal cortex. It's function is to act on the distal convoluted tubule and the collecting duct of the nephron to make them more permeable to sodium to allow for its reuptake (in addition to allowing potassium wasting). As a result, water follows the sodium back into the body. The water retention contributes to an increased blood volume. Angiotensin II from the circulation binds to receptors on the zona glomerulosa cell membrane, activating the G protein and triggering a signaling cascade. The end result is the activation of the steroidogenic acute regulatory (StAR) protein that permits cholesterol uptake into the mitochondria. From there, cholesterol undergoes a series of reactions in both the mitochondrion and the smooth endoplasmic reticulum (steroidogenesis) where it finally becomes aldosterone. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Krissa Created On: March 25, 2019 at 10:30 Last Updated: March 25, 2019 at 10:30
PW064538 View Pathway	signaling Aldosterone Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: December 19, 2017 at 08:07 Last Updated: December 19, 2017 at 08:07
PW146297 View Pathway	drug action Alcloxa Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:53 Last Updated: October 07, 2023 at 17:53
PW132210 View Pathway	metabolic Alcloxa Drug Metabolism Homo sapiens Alcloxa is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Alcloxa passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:09 Last Updated: September 21, 2023 at 20:09
PW144369 View Pathway	drug action Alclometasone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:29 Last Updated: October 07, 2023 at 13:29
PW127740 View Pathway	drug action Alclometasone Action Pathway Homo sapiens Alclometasone is a synthetic glucocorticoid steroid for topical use in the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Alclometasone is a selective glucocorticoid receptor agonist. The exact mechanism of the anti-inflammatory action is still unclear. It is likely that by binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Aclometasone also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. Alclometasone is administered as a topical cream or ointment. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: May 29, 2023 at 17:38 Last Updated: May 29, 2023 at 17:38
PW175964 View Pathway	metabolic Alclofenac Predicted Metabolism Pathway new Homo sapiens Metabolites of Alclofenac are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 12:50 Last Updated: November 29, 2023 at 12:50