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Pathways

PathWhiz ID Pathway Meta Data

PW000137

Pw000137 View Pathway
drug action

Alendronate Action Pathway

Homo sapiens
Alendronate (also known as alendronic acid) is a type of bisphosphonate medication with nitrogen that can inhibit FPP synthase, which can block the pathway that produce geranyl-PP and farnesyl pyrophosphate. Geranyl-PP and farnesyl pyrophosphate are the compounds that are required for small GTPase signalling proteins undergo post-translational farnesylation and geranylgeranylation. Therefore, lack the formation of geranyl-PP and farnesyl pyrophosphate can prevent osteoclast activity, which lead to prevention of reduced bone resorption and turnover.

PW175965

Pw175965 View Pathway
metabolic

Alectinib Predicted Metabolism Pathway new

Homo sapiens
Metabolites of Alectinib are predicted with biotransformer.

PW146369

Pw146369 View Pathway
drug action

Alectinib Drug Metabolism Action Pathway

Homo sapiens

PW122401

Pw122401 View Pathway
physiological

Aldosterone from Steroidogenesis

Homo sapiens
Aldosterone is a hormone produced in the zona glomerulosa of the adrenal cortex. It's function is to act on the distal convoluted tubule and the collecting duct of the nephron to make them more permeable to sodium to allow for its reuptake (in addition to allowing potassium wasting). As a result, water follows the sodium back into the body. The water retention contributes to an increased blood volume. Angiotensin II from the circulation binds to receptors on the zona glomerulosa cell membrane, activating the G protein and triggering a signaling cascade. The end result is the activation of the steroidogenic acute regulatory (StAR) protein that permits cholesterol uptake into the mitochondria. From there, cholesterol undergoes a series of reactions in both the mitochondrion and the smooth endoplasmic reticulum (steroidogenesis) where it finally becomes aldosterone.

PW064538

Pw064538 View Pathway
signaling

Aldosterone

Homo sapiens

PW146297

Pw146297 View Pathway
drug action

Alcloxa Drug Metabolism Action Pathway

Homo sapiens

PW132210

Pw132210 View Pathway
metabolic

Alcloxa Drug Metabolism

Homo sapiens
Alcloxa is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Alcloxa passes through the liver and is then excreted from the body mainly through the kidney.

PW144369

Pw144369 View Pathway
drug action

Alclometasone Drug Metabolism Action Pathway

Homo sapiens

PW127740

Pw127740 View Pathway
drug action

Alclometasone Action Pathway

Homo sapiens
Alclometasone is a synthetic glucocorticoid steroid for topical use in the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Alclometasone is a selective glucocorticoid receptor agonist. The exact mechanism of the anti-inflammatory action is still unclear. It is likely that by binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Aclometasone also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. Alclometasone is administered as a topical cream or ointment.

PW175964

Pw175964 View Pathway
metabolic

Alclofenac Predicted Metabolism Pathway new

Homo sapiens
Metabolites of Alclofenac are predicted with biotransformer.