
PathWhiz ID | Pathway | Meta Data |
---|---|---|
PW000137 |
drug action
Alendronate Action PathwayHomo sapiens
Alendronate (also known as alendronic acid) is a type of bisphosphonate medication with nitrogen that can inhibit FPP synthase, which can block the pathway that produce geranyl-PP and farnesyl pyrophosphate. Geranyl-PP and farnesyl pyrophosphate are the compounds that are required for small GTPase signalling proteins undergo post-translational farnesylation and geranylgeranylation. Therefore, lack the formation of geranyl-PP and farnesyl pyrophosphate can prevent osteoclast activity, which lead to prevention of reduced bone resorption and turnover.
|
Creator: WishartLab Created On: August 04, 2013 at 21:45 Last Updated: August 04, 2013 at 21:45 |
PW175965 |
Alectinib Predicted Metabolism Pathway newHomo sapiens
Metabolites of Alectinib are predicted with biotransformer.
|
Creator: Omolola Created On: November 29, 2023 at 12:51 Last Updated: November 29, 2023 at 12:51 |
PW146369 |
drug action
Alectinib Drug Metabolism Action PathwayHomo sapiens
|
Creator: Ray Kruger Created On: October 07, 2023 at 18:02 Last Updated: October 07, 2023 at 18:02 |
PW122401 |
physiological
Aldosterone from SteroidogenesisHomo sapiens
Aldosterone is a hormone produced in the zona glomerulosa of the adrenal cortex. It's function is to act on the distal convoluted tubule and the collecting duct of the nephron to make them more permeable to sodium to allow for its reuptake (in addition to allowing potassium wasting). As a result, water follows the sodium back into the body. The water retention contributes to an increased blood volume. Angiotensin II from the circulation binds to receptors on the zona glomerulosa cell membrane, activating the G protein and triggering a signaling cascade. The end result is the activation of the steroidogenic acute regulatory (StAR) protein that permits cholesterol uptake into the mitochondria. From there, cholesterol undergoes a series of reactions in both the mitochondrion and the smooth endoplasmic reticulum (steroidogenesis) where it finally becomes aldosterone.
|
Creator: Krissa Created On: March 25, 2019 at 10:30 Last Updated: March 25, 2019 at 10:30 |
PW064538 |
signaling
AldosteroneHomo sapiens
|
Creator: Guest: Anonymous Created On: December 19, 2017 at 08:07 Last Updated: December 19, 2017 at 08:07 |
PW146297 |
drug action
Alcloxa Drug Metabolism Action PathwayHomo sapiens
|
Creator: Ray Kruger Created On: October 07, 2023 at 17:53 Last Updated: October 07, 2023 at 17:53 |
PW132210 |
Alcloxa Drug MetabolismHomo sapiens
Alcloxa is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Alcloxa passes through the liver and is then excreted from the body mainly through the kidney.
|
Creator: Ray Kruger Created On: September 21, 2023 at 20:09 Last Updated: September 21, 2023 at 20:09 |
PW144369 |
drug action
Alclometasone Drug Metabolism Action PathwayHomo sapiens
|
Creator: Ray Kruger Created On: October 07, 2023 at 13:29 Last Updated: October 07, 2023 at 13:29 |
PW127740 |
drug action
Alclometasone Action PathwayHomo sapiens
Alclometasone is a synthetic glucocorticoid steroid for topical use in the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Alclometasone is a selective glucocorticoid receptor agonist. The exact mechanism of the anti-inflammatory action is still unclear. It is likely that by binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Aclometasone also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. Alclometasone is administered as a topical cream or ointment.
|
Creator: Daphnee Created On: May 29, 2023 at 17:38 Last Updated: May 29, 2023 at 17:38 |
PW175964 |
Alclofenac Predicted Metabolism Pathway newHomo sapiens
Metabolites of Alclofenac are predicted with biotransformer.
|
Creator: Omolola Created On: November 29, 2023 at 12:50 Last Updated: November 29, 2023 at 12:50 |