PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145427 View Pathway	drug action Aminophenazone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:48 Last Updated: October 07, 2023 at 15:48
PW175966 View Pathway	metabolic Aminohippuric acid Predicted Metabolism Pathway new Homo sapiens Metabolites of Aminohippuric acid are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 12:51 Last Updated: November 29, 2023 at 12:51
PW144483 View Pathway	drug action Aminoglutethimide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:43 Last Updated: October 07, 2023 at 13:43
PW144632 View Pathway	drug action Aminocaproic acid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:04 Last Updated: October 07, 2023 at 14:04
PW124120 View Pathway	drug action Aminocaproic Acid Drug Action Action Pathway (New) Homo sapiens Aminocaproic acid (also known as ε-aminocaproic acid, ε-Ahx, or 6-aminohexanoic acid; brand name Amicar) is a derivative of lysine, meaning that it acts as an amino acid analogue and can alter functionality of enzymes that require lysine residue binding (e.g. amino acid transporters such as the SLC3A2/SLC7A6 proteins, fibrin, tissue-type plasminogen activator, apolipoprotein(a), aldehyde oxidase, etc.). After oral or intravenous administration, it reaches the bloodstream and can act at the site of vascular injury (or other cause of excess bleeding) where the coagulation (i.e. blood clotting) takes place. Aminocaproic acid is an antifibrinolytic drug. Antifibrinolytics drugs are commonly used during major surgery to prevent significant blood loss (e.g. a liver transplant). By reversibly blocking the binding sites on plasminogen, aminocaproic acid creates a ‘blockade’ in the process of fibrinolysis - this blockade inhibits plasminogen binding to fibrin and the conversion of plasminogen to plasmin (a proteolytic enzyme), preventing fibrin degradation to maintain the stability of fibrin mesh/clots formed through the coagulation cascade. Thus, it reduces clot breakdown and can treat acute bleeding due to elevated fibrinolysis. An orphan drug FDA-approved to prevent recurring hemorrhage in certain patients, aminocaproic acid is also used off-label to control bleeding in patients with immune or nonimmune severe thrombocytopenia (bleeding disorder due to low platelet count). Unlike many other antifibrinolytics, it has no serious side effects at therapeutic doses and there is no evidence that suggests an increased risk of thrombosis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Nitya Khetarpal Created On: August 26, 2020 at 15:53 Last Updated: August 26, 2020 at 15:53
PW000308 View Pathway	drug action Aminocaproic Acid Action Pathway Homo sapiens Aminocaproic acid, brand name Amicar, is a derivate of lysine and is an antifibrinolytic drug. Antifibrinolytics drugs are commonly used during major surgery to prevent significant blood loss. These drugs reversibly blocks the binding sites on plasminogen. This blockade inhibits plasminogen binding to fibrin and the conversion of plasminogen to plasmin. These prevents fibrin degradation and maintains the stability of fibrin clots. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW176447 View Pathway	metabolic Aminobenzoic acid Predicted Metabolism Pathway Homo sapiens Metabolites of Template4MB1 are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 12, 2023 at 13:20 Last Updated: December 12, 2023 at 13:20
PW064551 View Pathway	metabolic Amino Sugar Metabolism Mus musculus Amino sugars are sugar molecules containing an amine group. They make up many polysaccharides including, glycosaminoglycans or mucopolysaccharides. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: January 16, 2018 at 11:11 Last Updated: January 16, 2018 at 11:11
PW088194 View Pathway	metabolic Amino Sugar Metabolism Bos taurus Amino sugars are sugar molecules containing an amine group. They make up many polysaccharides including, glycosaminoglycans or mucopolysaccharides. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 10:56 Last Updated: August 10, 2018 at 10:56
PW088300 View Pathway	metabolic Amino Sugar Metabolism Rattus norvegicus Amino sugars are sugar molecules containing an amine group. They make up many polysaccharides including, glycosaminoglycans or mucopolysaccharides. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 13:26 Last Updated: August 10, 2018 at 13:26