
PathWhiz ID | Pathway | Meta Data |
---|---|---|
PW144914 |
drug action
Proparacaine Drug Metabolism Action PathwayHomo sapiens
|
Creator: Ray Kruger Created On: October 07, 2023 at 14:41 Last Updated: October 07, 2023 at 14:41 |
PW000409 |
drug action
Proparacaine Action PathwayHomo sapiens
Proparacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Proparacaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. For this to happen, the sodium channel must first become active so that so that gating mechanism is in the open state. Therefore proparacaine preferentially inhibits neurons that are actively firing.
|
Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45 |
PW126577 |
drug action
ProparacaineHomo sapiens
Proparacaine is a topical anesthetic that is made up of an amino ester group and used for local anesthetic. Proparacaine acts on the neuronal membrane and inhibits ionic flux therefore inhibiting action potential. It also binds and antagonizes the function of voltage gated sodium channels. There is an unknown mechanism where proparacaine may limit sodium ion permeability through the lipid layer of the nerve cell membrane.
|
Creator: Selena Created On: January 16, 2022 at 16:51 Last Updated: January 16, 2022 at 16:51 |
PW176228 |
Propantheline Predicted Metabolism PathwayHomo sapiens
Metabolites of Propantheline are predicted with biotransformer.
|
Creator: Omolola Created On: December 04, 2023 at 12:57 Last Updated: December 04, 2023 at 12:57 |
PW144890 |
drug action
Propantheline Drug Metabolism Action PathwayHomo sapiens
|
Creator: Ray Kruger Created On: October 07, 2023 at 14:38 Last Updated: October 07, 2023 at 14:38 |
PW128010 |
drug action
Propantheline Action PathwayHomo sapiens
Propantheline is an antimuscarinic agent used to treat urinary incontinence, hyperhidrosis, as well as cramps and spasms of the stomach, intestines, and bladder. For the treatment of enuresis. It has also been used for hyperhidrosis, and cramps or spasms of the stomach, intestines or bladder. Propantheline is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Propantheline is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic). Propantheline is administered as an oral tablet. Possible side effects may include dry mouth, dizziness, nervousness, and headache.
|
Creator: Hayley Created On: June 29, 2023 at 09:47 Last Updated: June 29, 2023 at 09:47 |
PW501145 |
Propanoyl-CoA DegradationCitrobacter youngae ATCC 29220
The degradation of propanoyl-CoA starts with propanoyl-CoA undergoing a decarboxylase reaction by reacting with hydrogen carbonate and ATP resulting in the release of a phosphate, an ADP, a hydrogen ion and an S-methylmalonyl-CoA. This compound in turn reacts through an epimerase reaction resulting in the release of a R-methylmalonyl-CoA. This compound in turn can undergo a reversible reaction through a methylmalonyl-CoA mutase resulting in the release of a succinyl-CoA. This compound can be converted back to R-methylmalonyl-CoA through a methylmalonyl-CoA mutase.
Methylmalonyl-CoA can then be converted into propanoyl-CoA through a methylmalonyl CoA decarboxylase . This compound in turn reacts with a succinate through a propionyl-CoA succinate CoA transferase resulting in the release of a propanoate and a succinyl-CoA.
|
Creator: Julia Wakoli Created On: February 05, 2025 at 11:02 Last Updated: February 05, 2025 at 11:02 |
PW501246 |
Propanoyl-CoA DegradationKluyvera ascorbata ATCC 33433
The degradation of propanoyl-CoA starts with propanoyl-CoA undergoing a decarboxylase reaction by reacting with hydrogen carbonate and ATP resulting in the release of a phosphate, an ADP, a hydrogen ion and an S-methylmalonyl-CoA. This compound in turn reacts through an epimerase reaction resulting in the release of a R-methylmalonyl-CoA. This compound in turn can undergo a reversible reaction through a methylmalonyl-CoA mutase resulting in the release of a succinyl-CoA. This compound can be converted back to R-methylmalonyl-CoA through a methylmalonyl-CoA mutase.
Methylmalonyl-CoA can then be converted into propanoyl-CoA through a methylmalonyl CoA decarboxylase . This compound in turn reacts with a succinate through a propionyl-CoA succinate CoA transferase resulting in the release of a propanoate and a succinyl-CoA.
|
Creator: Julia Wakoli Created On: February 05, 2025 at 11:57 Last Updated: February 05, 2025 at 11:57 |
PW495660 |
Propanoyl-CoA DegradationEscherichia coli (strain UTI89 / UPEC)
The degradation of propanoyl-CoA starts with propanoyl-CoA undergoing a decarboxylase reaction by reacting with hydrogen carbonate and ATP resulting in the release of a phosphate, an ADP, a hydrogen ion and an S-methylmalonyl-CoA. This compound in turn reacts through an epimerase reaction resulting in the release of a R-methylmalonyl-CoA. This compound in turn can undergo a reversible reaction through a methylmalonyl-CoA mutase resulting in the release of a succinyl-CoA. This compound can be converted back to R-methylmalonyl-CoA through a methylmalonyl-CoA mutase.
Methylmalonyl-CoA can then be converted into propanoyl-CoA through a methylmalonyl CoA decarboxylase . This compound in turn reacts with a succinate through a propionyl-CoA succinate CoA transferase resulting in the release of a propanoate and a succinyl-CoA.
|
Creator: Julia Wakoli Created On: February 03, 2025 at 13:13 Last Updated: February 03, 2025 at 13:13 |
PW497914 |
Propanoyl-CoA DegradationMegasphaera elsdenii DSM 20460
The degradation of propanoyl-CoA starts with propanoyl-CoA undergoing a decarboxylase reaction by reacting with hydrogen carbonate and ATP resulting in the release of a phosphate, an ADP, a hydrogen ion and an S-methylmalonyl-CoA. This compound in turn reacts through an epimerase reaction resulting in the release of a R-methylmalonyl-CoA. This compound in turn can undergo a reversible reaction through a methylmalonyl-CoA mutase resulting in the release of a succinyl-CoA. This compound can be converted back to R-methylmalonyl-CoA through a methylmalonyl-CoA mutase.
Methylmalonyl-CoA can then be converted into propanoyl-CoA through a methylmalonyl CoA decarboxylase . This compound in turn reacts with a succinate through a propionyl-CoA succinate CoA transferase resulting in the release of a propanoate and a succinyl-CoA.
|
Creator: Julia Wakoli Created On: February 04, 2025 at 10:07 Last Updated: February 04, 2025 at 10:07 |