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CHEBI:16015 ChEBI 388356 ChemSpider 6022 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 937 ChemSpider 1.0 Cytidine triphosphate HMDB00250 HMDB CHEBI:16134 ChEBI 388352 ChemSpider HMDB01341 HMDB 1.0 9271300 ChemSpider UDP-N-acetylhexosamine pyrophosphorylase 6133 PubChem-compound CHEBI:62165 ChEBI HMDB00148 HMDB C00329 KEGG Compound 1.0 ATP BioCyc CHEBI:16264 ChEBI 53188-23-1 CAS HMDB00263 HMDB C15H26N2O12 Chitobiose 426.14856 C8H16NO9P N-Acetyl-D-Glucosamine 6-Phosphate 301.05627 Putative N-acetylglucosamine-6-phosphate deacetylase 559142 ChemSpider Sialin N-acylneuraminate cytidylyltransferase P46926 UniProt 1.0 5746 ChemSpider HMDB01206 HMDB 5742 ChemSpider 1.0 HMDB00230 HMDB 17216232 ChemSpider SMP00045 SMPDB Hexokinase-1 Pyrophosphate Cytidine monophosphate N-acetylneuraminic acid HMDB00243 HMDB Transport264 false N-Acetylneuraminic acid (↔) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Lysosome LEFT_TO_RIGHT HMDB00124 HMDB CHEBI:63154 ChEBI 6031 PubChem-compound Q8TBE9 UniProt C00461 KEGG Compound 439174 PubChem-compound C01674 KEGG Compound SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS 440273 PubChem-compound 440272 PubChem-compound PPI BioCyc Sialic acid synthase 138-08-9 CAS CHEBI:17029 ChEBI HMDB01423 HMDB O95394 UniProt 392810 ChemSpider HMDB00215 HMDB 388319 ChemSpider C5H10N2O3 L-Glutamine 146.06914 C00352 KEGG Compound L-Glutamic acid Cytosol C00357 KEGG Compound 1.0 131-48-6 CAS 395082 ChemSpider N-ACETYLNEURAMINATE BioCyc Phosphoenolpyruvic acid Fructose 6-phosphate C6H12O6 D-Fructose 180.06339 C00009 KEGG Compound C00008 KEGG Compound 3616-42-0 CAS C00128 KEGG Compound C8H16NO9P N-Acetyl-D-mannosamine 6-phosphate 301.05627 1.0 C00001 KEGG Compound CTP BioCyc CHEBI:18361 ChEBI CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound 1031 ChemSpider 4.0 C8H15NO6 N-Acetylmannosamine 221.08994 HMDB01429 HMDB 388775 ChemSpider 1.0 Adenosine triphosphate C00010 KEGG Compound FRUCTOSE-6P BioCyc C00015 KEGG Compound C00014 KEGG Compound C6H14NO8P Glucosamine 6-phosphate 259.04572 C00013 KEGG Compound CHEBI:7125 ChEBI Q9NR45 UniProt C00140 KEGG Compound 1.0 Q9BXD5 UniProt D-GLUCOSAMINE-6-P BioCyc Pyruvic acid N-Acetyl-D-mannosamine 6-phosphate Chitin C00022 KEGG Compound 56-65-5 CAS C00025 KEGG Compound SMILES [H][C@]1(O[C@](C[C@H](O)[C@H]1NC(C)=O)(OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(N)=NC1=O)C(O)=O)[C@H](O)[C@H](O)CO C00024 KEGG Compound 62713 ChemSpider ACET BioCyc N-Acetyl-D-glucosamine N-ACETYL-D-MANNOSAMINE BioCyc N-Acetylneuraminate 9-phosphate BiologicalState23 BiologicalState22 577-76-4 CAS CL:0000000 CELL TYPE ONTOLOGY C00033 KEGG Compound C02336 KEGG Compound N-ACETYL-D-GLUCOSAMINE-1-P BioCyc 1.0 SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Glucosamine 6-phosphate SMILES [O-]P([O-])(=O)OP([O-])([O-])=O Q9Y223 UniProt P06865 UniProt 2.0 3615-17-6 CAS HMDB01514 HMDB C00043 KEGG Compound L-Glutamine 56-85-9 CAS HMDB00660 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O N-acylglucosamine 2-epimerase 4.0 PHOSPHO-ENOL-PYRUVATE BioCyc C9H14N2O12P2 Uridine 5'-diphosphate 404.0022 HMDB00538 HMDB Uridine 5'-diphosphate 53477814 PubChem-compound 1.0 UTP BioCyc SMILES OC(=O)C(=C)OP(O)(O)=O 389821 ChemSpider 2.0 5903 ChemSpider Fructose 6-phosphate CHEBI:47977 ChEBI Beta-hexosaminidase subunit alpha 399508 ChemSpider SMILES CC(O)=O N-acylglucosamine 2-epimerase Adenosine diphosphate 2.0 Hexokinase-1 7732-18-5 CAS C28H49N3O16 Chitin 683.3113 Sialic acid synthase Glucosamine-6-phosphate isomerase 1 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase 11096158 PubChem-compound N-Acetylneuraminic acid C00063 KEGG Compound AMMONIA BioCyc SMILES N 56-86-0 CAS Bifunctional UDP-N-acetyl glucosamine 2-epimerase / N-acetylmannosamine kinase SMILES CC(=O)N[C@@H]1[C@@H](O)C[C@](O)(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O SMILES CC(=O)N[C@H]1[C@H](O)CC(O)(O[C@@H]1[C@H](O)[C@H](O)COP(O)(O)=O)C(O)=O Adenosine diphosphate 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1 BioCyc HMDB00641 HMDB Uridine diphosphate-N-acetylglucosamine C10H16N5O13P3 Adenosine triphosphate 506.99576 Q06210 UniProt 445675 PubChem-compound C00064 KEGG Compound 6866-69-9 CAS 1.0 Pyrophosphate Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 SMILES CC(=O)C(O)=O Q8NFW8 UniProt 65-47-4 CAS C00074 KEGG Compound Ammonia Adenosine triphosphate 1.0 C19910 KEGG Compound 962 PubChem-compound 5800 ChemSpider 58-98-0 CAS C00075 KEGG Compound C00085 KEGG Compound BiologicalState9 BiologicalState8 Q9Y303 UniProt SMILES N[C@@H](CCC(O)=O)C(O)=O 5809 ChemSpider Glutamine--fructose-6-phosphate aminotransferase CHEBI:44897 ChEBI CHEBI:45744 ChEBI 14265-44-2 CAS 6176 PubChem-compound PYRUVATE BioCyc 1.0 58-64-0 CAS 22833609 PubChem-compound CMP-N-ACETYL-NEURAMINATE BioCyc 644102 PubChem-compound 444493 PubChem-compound 5941 ChemSpider P51606 UniProt SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O ACETYL-COA BioCyc CHEBI:18050 ChEBI H2O Water 18.010565 SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O SMILES N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O Glucosamine SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O Nucleus N-Acetyl-D-Glucosamine 6-Phosphate 1.0 Glucosamine-6-phosphate isomerase 1 102029-88-9 CAS 1.0 HMDB06268 HMDB 1.0 SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1OP(O)(O)=O N-Acetyl-D-glucosamine 3063-71-6 CAS 980 ChemSpider 6.0 1.0 30572 ChemSpider 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + D-Fructose → Adenosine diphosphate + Fructose 6-phosphate LEFT_TO_RIGHT N-acylneuraminate cytidylyltransferase CPD-535 BioCyc 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + Glucosamine → Adenosine diphosphate + Glucosamine 6-phosphate LEFT_TO_RIGHT C2H4O2 Acetic acid 60.02113 5.1.3.8 false 5.1.3.8 N-Acetyl-D-glucosamine ↔ N-Acetylmannosamine REVERSIBLE Reaction637 false Uridine diphosphate-N-acetylglucosamine + Water → N-Acetylmannosamine + Uridine 5'-diphosphate LEFT_TO_RIGHT Reaction635 false N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate-N-acetylglucosamine LEFT_TO_RIGHT N-Acetylmannosamine C11H20NO12P N-Acetylneuraminate 9-phosphate 389.07233 64-19-7 CAS Chitobiose SMILES O 5.4.2.3 false 5.4.2.3 N-Acetyl-D-Glucosamine 6-Phosphate ↔ N-Acetyl-glucosamine 1-phosphate REVERSIBLE H3N Ammonia 17.026548 2.6.1.16 false 2.6.1.16 Fructose 6-phosphate + L-Glutamine → Glucosamine 6-phosphate + L-Glutamic acid LEFT_TO_RIGHT C11H19NO9 N-Acetylneuraminic acid 309.106 21252321 PubChem-compound N-acylglucosamine 2-epimerase 439709 PubChem-compound N-ACETYL-D-MANNOSAMINE-6P BioCyc 2.7.7.43 false 2.7.7.43 Cytidine triphosphate + N-Acetylneuraminic acid ↔ Cytidine monophosphate N-acetylneuraminic acid + Pyrophosphate REVERSIBLE 1005 PubChem-compound 1.0 5961 PubChem-compound 448209 PubChem-compound 643-13-0 CAS 528-04-1 CAS 6816 PubChem-compound Water Reaction643 false N-Acetyl-D-mannosamine 6-phosphate + Phosphoenolpyruvic acid + Water ↔ N-Acetylneuraminate 9-phosphate + Phosphate REVERSIBLE 3.1.3.29 false 3.1.3.29 N-Acetylneuraminate 9-phosphate + Water → N-Acetylneuraminic acid + Phosphate LEFT_TO_RIGHT 4.1.3.3 false 4.1.3.3 N-Acetylneuraminic acid → N-Acetylmannosamine + Pyruvic acid LEFT_TO_RIGHT 2.7.1.59 false 2.7.1.59 Adenosine triphosphate + N-Acetyl-D-glucosamine ↔ Adenosine diphosphate + N-Acetyl-D-Glucosamine 6-Phosphate REVERSIBLE ADP BioCyc Reaction642 false Adenosine triphosphate + N-Acetylmannosamine → Adenosine diphosphate + N-Acetyl-D-mannosamine 6-phosphate LEFT_TO_RIGHT C3H4O3 Pyruvic acid 88.016045 Reaction640 false N-Acetylmannosamine + Phosphoenolpyruvic acid + Water → N-Acetylneuraminic acid + Phosphate LEFT_TO_RIGHT N-Acetylneuraminic acid ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS BioCyc Lysosome N-ACETYL-D-GLUCOSAMINE-6-P BioCyc 1.0 Chitotriosidase-1 C04256 KEGG Compound N-acetyl-D-glucosamine kinase C04257 KEGG Compound 1.0 GO:0005829 GENE ONTOLOGY Phosphoacetylglucosamine mutase 393240 ChemSpider CHITOBIOSE BioCyc 1.0 Glucosamine 6-phosphate 1.0 CHEBI:15713 ChEBI O4P Phosphate 94.95342 D-Fructose 2.0 SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O CHEBI:15946 ChEBI Acetyl-CoA C8H15NO6 N-Acetyl-D-glucosamine 221.08994 TransportCatalysis221 ACTIVATION Q16222 UniProt N-acetylneuraminate lyase 873185-52-5 CAS Phosphoacetylglucosamine mutase 217 ChemSpider C9H15N2O15P3 Uridine triphosphate 483.96854 N-acylneuraminate cytidylyltransferase SMILES [O-]P([O-])([O-])=O C6H13NO5 Glucosamine 179.07938 1398-61-4 CAS C6H13O9P Fructose 6-phosphate 260.02972 GO:0005764 GENE ONTOLOGY C17H27N3O17P2 Uridine diphosphate-N-acetylglucosamine 607.08154 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase SMILES CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O C8H16NO9P N-Acetyl-glucosamine 1-phosphate 301.05627 GLN BioCyc 7664-41-7 CAS GLT BioCyc GO:0005634 GENE ONTOLOGY 69507 PubChem-compound 445063 PubChem-compound Chitotriosidase-1 UDP-N-acetylhexosamine pyrophosphorylase Sialin 222 PubChem-compound O7P2 Pyrophosphate 173.91193 C06241 KEGG Compound 1.0 5957 PubChem-compound C9H16N3O14P3 Cytidine triphosphate 482.9845 GO:0005741 GENE ONTOLOGY 1.0 3.5.99.6 false 3.5.99.6 Glucosamine 6-phosphate + Water → Ammonia + Fructose 6-phosphate LEFT_TO_RIGHT 3.5.1.25 false 3.5.1.25 N-Acetyl-D-Glucosamine 6-Phosphate + Water → Acetic acid + Glucosamine 6-phosphate LEFT_TO_RIGHT CHEBI:15873 ChEBI 2.3.1.4 false 2.3.1.4 Acetyl-CoA + Glucosamine 6-phosphate → Coenzyme A + N-Acetyl-D-Glucosamine 6-Phosphate LEFT_TO_RIGHT 3.2.1.52 false 3.2.1.52 Chitobiose + Water → 2 N-Acetyl-D-glucosamine LEFT_TO_RIGHT 3.2.1.14 false 3.2.1.14 Chitin → N-Acetyl-D-glucosamine LEFT_TO_RIGHT 3.2.1.14 false 3.2.1.14 Chitin → Chitobiose LEFT_TO_RIGHT Beta-hexosaminidase subunit alpha N-acetylneuraminate lyase N-acylneuraminate-9-phosphatase 2.0 N-Acetylneuraminic acid 440996 PubChem-compound N-acetylneuraminate lyase Glucosamine-6-phosphate isomerase 1 Uridine triphosphate C3H5O6P Phosphoenolpyruvic acid 167.98238 C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY Coenzyme A Mitochondrial Outer Membrane HMDB03362 HMDB Glucosamine 6-phosphate N-acetyltransferase CPD-8587 BioCyc HMDB01062 HMDB SMILES N[C@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O Putative N-acetylglucosamine-6-phosphate deacetylase UDP BioCyc CHEBI:1146900 ChEBI P19367 UniProt CHEBI:28645 ChEBI 1.0 Glucosamine 6-phosphate N-acetyltransferase 1.0 14000-31-8 CAS CO-A BioCyc 72-89-9 CAS C21H36N7O16P3S Coenzyme A 767.11523 1.0 1.0 Cytoplasm 1.0 1.0 1.0 Cell CHEBI:15784 ChEBI CHEBI:15422 ChEBI 6557 ChemSpider SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 1.0 439213 PubChem-compound 127-17-3 CAS 3416-24-8 CAS 439217 PubChem-compound C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound Q9NRA2 UniProt Water Glucosamine 6-phosphate N-acetyltransferase N-acetyl-D-glucosamine kinase N-acylneuraminate-9-phosphatase UDP-N-ACETYL-D-GLUCOSAMINE BioCyc HMDB00082 HMDB SMILES CC(=O)N[C@H]1C(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O SMILES CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(O)=O)[C@@H]1O CHEBI:16761 ChEBI GLUCOSAMINE BioCyc HMDB01176 HMDB CHEBI:506227 ChEBI 9606 TAXONOMY CHEBI:15366 ChEBI ReactionCatalysis113 ACTIVATION ReactionCatalysis114 ACTIVATION 389249 ChemSpider ReactionCatalysis111 ACTIVATION 389248 ChemSpider ReactionCatalysis112 ACTIVATION ReactionCatalysis110 ACTIVATION Q13231 UniProt 392413 ChemSpider HMDB00290 HMDB HMDB00051 HMDB 1.0 HMDB00295 HMDB SMILES CC(=O)NC1[C@H](O)OC(CO)[C@@H](COC[C@@H]2OC(CO)[C@@H](COC[C@@H]3OC(CO)[C@@H](O)[C@H](O)C3NC(C)=O)[C@H](O)C2NC(C)=O)[C@@H]1O HMDB02111 HMDB Q96EK6 UniProt 1.0 N-Acetyl-glucosamine 1-phosphate N-acetyl-D-glucosamine kinase Amino Sugar Metabolism ReactionCatalysis108 ACTIVATION ReactionCatalysis109 ACTIVATION 171 ChemSpider CHEBI:32816 ChEBI ReactionCatalysis107 ACTIVATION 1.0 CHEBI:15377 ChEBI CHEBI:17677 ChEBI C20H31N4O16P Cytidine monophosphate N-acetylneuraminic acid 614.1473 C00645 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 4.0 1.0 Phosphate 1.0 PW000008 PathWhiz 1.0 CHEBI:16556 ChEBI HMDB01367 HMDB HMDB01129 HMDB Q9UJ70 UniProt Acetic acid SMILES N[C@@H](CCC(N)=O)C(O)=O 1.0 30776539 ChemSpider HMDB01121 HMDB ReactionCatalysis128 ACTIVATION ReactionCatalysis129 ACTIVATION ReactionCatalysis126 ACTIVATION ReactionCatalysis127 ACTIVATION HMDB03556 HMDB ReactionCatalysis124 ACTIVATION 1060 PubChem-compound 63-39-8 CAS 1061 PubChem-compound ReactionCatalysis125 ACTIVATION ReactionCatalysis122 ACTIVATION ReactionCatalysis123 ACTIVATION ReactionCatalysis120 ACTIVATION CHEBI:17659 ChEBI ReactionCatalysis121 ACTIVATION N-Acetylneuraminic acid SMILES CC(=O)N[C@@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O CHEBI:15351 ChEBI HMDB00042 HMDB SMILES OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O HMDB01254 HMDB HMDB00285 HMDB 1.0 176 PubChem-compound SMILES [H][C@@]1(O)O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1NC(C)=O 85-61-0 CAS ReactionCatalysis119 ACTIVATION 7512-17-6 CAS ReactionCatalysis116 ACTIVATION Sialin Chitotriosidase- 1 Beta- hexosaminidase subunit alpha Chitotriosidase- 1 N-acetyl-D- glucosamine kinase Putative N- acetylglucosamine- 6-phosphate deacetylase Glucosamine 6-phosphate N- acetyltransferase Glucosamine- 6-phosphate isomerase 1 Glutamine-- fructose-6- phosphate aminotransferase Phosphoacetylglucosamine mutase UDP-N- acetylhexosamine pyrophosphorylase N- acylglucosamine 2-epimerase Bifunctional UDP-N-acetyl glucosamine 2-epimerase / N- acetylmannosamine kinase Hexokinase-1 Hexokinase-1 Sialic acid synthase N- acetylneuraminate lyase Bifunctional UDP-N-acetyl glucosamine 2-epimerase / N- acetylmannosamine kinase Sialic acid synthase N- acylneuraminate- 9-phosphatase N- acylneuraminate cytidylyltransferase N-Acetylneuraminic acid N-Acetylneuraminic acid Chitin Chitobiose H 2 O N-Acetyl-D-glucosamine ATP ADP N-Acetyl-D-Glucosamine 6-Phosphate H 2 O Glucosamine 6-phosphate Acetic acid Acetyl-CoA CoA H 2 O Fructose 6-phosphate NH 3 L-Glutamine L-Glutamic acid N-Acetyl-glucosamine 1-phosphate Uridine triphosphate Uridine diphosphate-N- acetylglucosamine PP i N-Acetylmannosamine H 2 O Uridine 5'-diphosphate D-Fructose ATP ADP Glucosamine ATP ADP Phosphoenolpyruvic acid H 2 O P i Pyruvic acid ATP N-Acetyl-D-mannosamine 6-phosphate ADP Phosphoenolpyruvic acid H 2 O N-Acetylneuraminate 9-phosphate P i H 2 O P i Cytidine triphosphate Cytidine monophosphate N-acetylneuraminic acid PP i Magnesium Magnesium Extracellular Space Intracellular Space Lysosome Lysosome
CHEBI:16015 ChEBI 388356 ChemSpider 6022 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 937 ChemSpider 1.0 Cytidine triphosphate HMDB00250 HMDB CHEBI:16134 ChEBI 388352 ChemSpider HMDB01341 HMDB 1.0 9271300 ChemSpider UDP-N-acetylhexosamine pyrophosphorylase 6133 PubChem-compound CHEBI:62165 ChEBI HMDB00148 HMDB C00329 KEGG Compound 1.0 ATP BioCyc CHEBI:16264 ChEBI 53188-23-1 CAS HMDB00263 HMDB C15H26N2O12 Chitobiose 426.14856 C8H16NO9P N-Acetyl-D-Glucosamine 6-Phosphate 301.05627 Putative N-acetylglucosamine-6-phosphate deacetylase 559142 ChemSpider Sialin N-acylneuraminate cytidylyltransferase P46926 UniProt 1.0 5746 ChemSpider HMDB01206 HMDB 5742 ChemSpider 1.0 HMDB00230 HMDB 17216232 ChemSpider http://identifiers.org/smpdb/SMP00045 SMPDB Hexokinase-1 Pyrophosphate Cytidine monophosphate N-acetylneuraminic acid HMDB00243 HMDB Transport264 false N-Acetylneuraminic acid (↔) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Lysosome LEFT_TO_RIGHT HMDB00124 HMDB CHEBI:63154 ChEBI 6031 PubChem-compound Q8TBE9 UniProt C00461 KEGG Compound 439174 PubChem-compound C01674 KEGG Compound SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS 440273 PubChem-compound 440272 PubChem-compound PPI BioCyc Sialic acid synthase 138-08-9 CAS CHEBI:17029 ChEBI HMDB01423 HMDB O95394 UniProt 392810 ChemSpider HMDB00215 HMDB 388319 ChemSpider C5H10N2O3 L-Glutamine 146.06914 C00352 KEGG Compound L-Glutamic acid Cytosol C00357 KEGG Compound 1.0 131-48-6 CAS 395082 ChemSpider N-ACETYLNEURAMINATE BioCyc Phosphoenolpyruvic acid Fructose 6-phosphate C6H12O6 D-Fructose 180.06339 C00009 KEGG Compound C00008 KEGG Compound 3616-42-0 CAS C00128 KEGG Compound C8H16NO9P N-Acetyl-D-mannosamine 6-phosphate 301.05627 1.0 C00001 KEGG Compound CTP BioCyc CHEBI:18361 ChEBI CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound 1031 ChemSpider 4.0 C8H15NO6 N-Acetylmannosamine 221.08994 HMDB01429 HMDB 388775 ChemSpider 1.0 Adenosine triphosphate C00010 KEGG Compound FRUCTOSE-6P BioCyc C00015 KEGG Compound C00014 KEGG Compound C6H14NO8P Glucosamine 6-phosphate 259.04572 C00013 KEGG Compound CHEBI:7125 ChEBI Q9NR45 UniProt C00140 KEGG Compound 1.0 Q9BXD5 UniProt D-GLUCOSAMINE-6-P BioCyc Pyruvic acid N-Acetyl-D-mannosamine 6-phosphate Chitin C00022 KEGG Compound 56-65-5 CAS C00025 KEGG Compound SMILES [H][C@]1(O[C@](C[C@H](O)[C@H]1NC(C)=O)(OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(N)=NC1=O)C(O)=O)[C@H](O)[C@H](O)CO C00024 KEGG Compound 62713 ChemSpider ACET BioCyc N-Acetyl-D-glucosamine N-ACETYL-D-MANNOSAMINE BioCyc N-Acetylneuraminate 9-phosphate BiologicalState23 Homo sapiens, Cell, Nucleus BiologicalState22 Homo sapiens, Cell, Mitochondrial Outer Membrane 577-76-4 CAS CL:0000000 CELL TYPE ONTOLOGY C00033 KEGG Compound C02336 KEGG Compound N-ACETYL-D-GLUCOSAMINE-1-P BioCyc 1.0 SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Glucosamine 6-phosphate SMILES [O-]P([O-])(=O)OP([O-])([O-])=O Q9Y223 UniProt P06865 UniProt 2.0 3615-17-6 CAS HMDB01514 HMDB C00043 KEGG Compound L-Glutamine 56-85-9 CAS HMDB00660 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O N-acylglucosamine 2-epimerase 4.0 PHOSPHO-ENOL-PYRUVATE BioCyc C9H14N2O12P2 Uridine 5'-diphosphate 404.0022 HMDB00538 HMDB Uridine 5'-diphosphate 53477814 PubChem-compound 1.0 UTP BioCyc SMILES OC(=O)C(=C)OP(O)(O)=O 389821 ChemSpider 2.0 5903 ChemSpider Fructose 6-phosphate CHEBI:47977 ChEBI Beta-hexosaminidase subunit alpha 399508 ChemSpider SMILES CC(O)=O N-acylglucosamine 2-epimerase Adenosine diphosphate 2.0 Hexokinase-1 7732-18-5 CAS C28H49N3O16 Chitin 683.3113 Sialic acid synthase Glucosamine-6-phosphate isomerase 1 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase 11096158 PubChem-compound N-Acetylneuraminic acid C00063 KEGG Compound AMMONIA BioCyc SMILES N 56-86-0 CAS Bifunctional UDP-N-acetyl glucosamine 2-epimerase / N-acetylmannosamine kinase SMILES CC(=O)N[C@@H]1[C@@H](O)C[C@](O)(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O SMILES CC(=O)N[C@H]1[C@H](O)CC(O)(O[C@@H]1[C@H](O)[C@H](O)COP(O)(O)=O)C(O)=O Adenosine diphosphate 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1 BioCyc HMDB00641 HMDB Uridine diphosphate-N-acetylglucosamine C10H16N5O13P3 Adenosine triphosphate 506.99576 Q06210 UniProt 445675 PubChem-compound C00064 KEGG Compound 6866-69-9 CAS 1.0 Pyrophosphate Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 SMILES CC(=O)C(O)=O Q8NFW8 UniProt 65-47-4 CAS C00074 KEGG Compound Ammonia Adenosine triphosphate 1.0 C19910 KEGG Compound 962 PubChem-compound 5800 ChemSpider 58-98-0 CAS C00075 KEGG Compound C00085 KEGG Compound BiologicalState9 Homo sapiens, Cell, Lysosome BiologicalState8 Homo sapiens, Cell, Cytoplasm Q9Y303 UniProt SMILES N[C@@H](CCC(O)=O)C(O)=O 5809 ChemSpider Glutamine--fructose-6-phosphate aminotransferase CHEBI:44897 ChEBI CHEBI:45744 ChEBI 14265-44-2 CAS 6176 PubChem-compound PYRUVATE BioCyc 1.0 58-64-0 CAS 22833609 PubChem-compound CMP-N-ACETYL-NEURAMINATE BioCyc 644102 PubChem-compound 444493 PubChem-compound 5941 ChemSpider P51606 UniProt SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O ACETYL-COA BioCyc CHEBI:18050 ChEBI H2O Water 18.010565 SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O SMILES N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O Glucosamine SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O Nucleus N-Acetyl-D-Glucosamine 6-Phosphate 1.0 Glucosamine-6-phosphate isomerase 1 102029-88-9 CAS 1.0 HMDB06268 HMDB 1.0 SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1OP(O)(O)=O N-Acetyl-D-glucosamine 3063-71-6 CAS 980 ChemSpider 6.0 1.0 30572 ChemSpider 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + D-Fructose → Adenosine diphosphate + Fructose 6-phosphate LEFT_TO_RIGHT N-acylneuraminate cytidylyltransferase CPD-535 BioCyc 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + Glucosamine → Adenosine diphosphate + Glucosamine 6-phosphate LEFT_TO_RIGHT C2H4O2 Acetic acid 60.02113 5.1.3.8 false 5.1.3.8 N-Acetyl-D-glucosamine ↔ N-Acetylmannosamine REVERSIBLE Reaction637 false Uridine diphosphate-N-acetylglucosamine + Water → N-Acetylmannosamine + Uridine 5'-diphosphate LEFT_TO_RIGHT Reaction635 false N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate-N-acetylglucosamine LEFT_TO_RIGHT N-Acetylmannosamine C11H20NO12P N-Acetylneuraminate 9-phosphate 389.07233 64-19-7 CAS Chitobiose SMILES O 5.4.2.3 false 5.4.2.3 N-Acetyl-D-Glucosamine 6-Phosphate ↔ N-Acetyl-glucosamine 1-phosphate REVERSIBLE H3N Ammonia 17.026548 2.6.1.16 false 2.6.1.16 Fructose 6-phosphate + L-Glutamine → Glucosamine 6-phosphate + L-Glutamic acid LEFT_TO_RIGHT C11H19NO9 N-Acetylneuraminic acid 309.106 21252321 PubChem-compound N-acylglucosamine 2-epimerase 439709 PubChem-compound N-ACETYL-D-MANNOSAMINE-6P BioCyc 2.7.7.43 false 2.7.7.43 Cytidine triphosphate + N-Acetylneuraminic acid ↔ Cytidine monophosphate N-acetylneuraminic acid + Pyrophosphate REVERSIBLE 1005 PubChem-compound 1.0 5961 PubChem-compound 448209 PubChem-compound 643-13-0 CAS 528-04-1 CAS 6816 PubChem-compound Water Reaction643 false N-Acetyl-D-mannosamine 6-phosphate + Phosphoenolpyruvic acid + Water ↔ N-Acetylneuraminate 9-phosphate + Phosphate REVERSIBLE 3.1.3.29 false 3.1.3.29 N-Acetylneuraminate 9-phosphate + Water → N-Acetylneuraminic acid + Phosphate LEFT_TO_RIGHT 4.1.3.3 false 4.1.3.3 N-Acetylneuraminic acid → N-Acetylmannosamine + Pyruvic acid LEFT_TO_RIGHT 2.7.1.59 false 2.7.1.59 Adenosine triphosphate + N-Acetyl-D-glucosamine ↔ Adenosine diphosphate + N-Acetyl-D-Glucosamine 6-Phosphate REVERSIBLE ADP BioCyc Reaction642 false Adenosine triphosphate + N-Acetylmannosamine → Adenosine diphosphate + N-Acetyl-D-mannosamine 6-phosphate LEFT_TO_RIGHT C3H4O3 Pyruvic acid 88.016045 Reaction640 false N-Acetylmannosamine + Phosphoenolpyruvic acid + Water → N-Acetylneuraminic acid + Phosphate LEFT_TO_RIGHT N-Acetylneuraminic acid ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS BioCyc Lysosome N-ACETYL-D-GLUCOSAMINE-6-P BioCyc 1.0 Chitotriosidase-1 C04256 KEGG Compound N-acetyl-D-glucosamine kinase C04257 KEGG Compound 1.0 GO:0005829 GENE ONTOLOGY Phosphoacetylglucosamine mutase 393240 ChemSpider CHITOBIOSE BioCyc 1.0 Glucosamine 6-phosphate 1.0 CHEBI:15713 ChEBI O4P Phosphate 94.95342 D-Fructose 2.0 SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O CHEBI:15946 ChEBI Acetyl-CoA C8H15NO6 N-Acetyl-D-glucosamine 221.08994 TransportCatalysis221 ACTIVATION Q16222 UniProt N-acetylneuraminate lyase 873185-52-5 CAS Phosphoacetylglucosamine mutase 217 ChemSpider C9H15N2O15P3 Uridine triphosphate 483.96854 N-acylneuraminate cytidylyltransferase SMILES [O-]P([O-])([O-])=O C6H13NO5 Glucosamine 179.07938 1398-61-4 CAS C6H13O9P Fructose 6-phosphate 260.02972 GO:0005764 GENE ONTOLOGY C17H27N3O17P2 Uridine diphosphate-N-acetylglucosamine 607.08154 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase SMILES CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O C8H16NO9P N-Acetyl-glucosamine 1-phosphate 301.05627 GLN BioCyc 7664-41-7 CAS GLT BioCyc GO:0005634 GENE ONTOLOGY 69507 PubChem-compound 445063 PubChem-compound Chitotriosidase-1 UDP-N-acetylhexosamine pyrophosphorylase Sialin 222 PubChem-compound O7P2 Pyrophosphate 173.91193 C06241 KEGG Compound 1.0 5957 PubChem-compound C9H16N3O14P3 Cytidine triphosphate 482.9845 GO:0005741 GENE ONTOLOGY 1.0 3.5.99.6 false 3.5.99.6 Glucosamine 6-phosphate + Water → Ammonia + Fructose 6-phosphate LEFT_TO_RIGHT 3.5.1.25 false 3.5.1.25 N-Acetyl-D-Glucosamine 6-Phosphate + Water → Acetic acid + Glucosamine 6-phosphate LEFT_TO_RIGHT CHEBI:15873 ChEBI 2.3.1.4 false 2.3.1.4 Acetyl-CoA + Glucosamine 6-phosphate → Coenzyme A + N-Acetyl-D-Glucosamine 6-Phosphate LEFT_TO_RIGHT 3.2.1.52 false 3.2.1.52 Chitobiose + Water → 2 N-Acetyl-D-glucosamine LEFT_TO_RIGHT 3.2.1.14 false 3.2.1.14 Chitin → N-Acetyl-D-glucosamine LEFT_TO_RIGHT 3.2.1.14 false 3.2.1.14 Chitin → Chitobiose LEFT_TO_RIGHT Beta-hexosaminidase subunit alpha N-acetylneuraminate lyase N-acylneuraminate-9-phosphatase 2.0 N-Acetylneuraminic acid 440996 PubChem-compound N-acetylneuraminate lyase Glucosamine-6-phosphate isomerase 1 Uridine triphosphate C3H5O6P Phosphoenolpyruvic acid 167.98238 C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY Coenzyme A Mitochondrial Outer Membrane HMDB03362 HMDB Glucosamine 6-phosphate N-acetyltransferase CPD-8587 BioCyc HMDB01062 HMDB SMILES N[C@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O Putative N-acetylglucosamine-6-phosphate deacetylase UDP BioCyc CHEBI:1146900 ChEBI P19367 UniProt CHEBI:28645 ChEBI 1.0 Glucosamine 6-phosphate N-acetyltransferase 1.0 14000-31-8 CAS CO-A BioCyc 72-89-9 CAS C21H36N7O16P3S Coenzyme A 767.11523 1.0 1.0 Cytoplasm 1.0 1.0 1.0 Cell CHEBI:15784 ChEBI CHEBI:15422 ChEBI 6557 ChemSpider SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 1.0 439213 PubChem-compound 127-17-3 CAS 3416-24-8 CAS 439217 PubChem-compound C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound Q9NRA2 UniProt Water Glucosamine 6-phosphate N-acetyltransferase N-acetyl-D-glucosamine kinase N-acylneuraminate-9-phosphatase UDP-N-ACETYL-D-GLUCOSAMINE BioCyc HMDB00082 HMDB SMILES CC(=O)N[C@H]1C(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O SMILES CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(O)=O)[C@@H]1O CHEBI:16761 ChEBI GLUCOSAMINE BioCyc HMDB01176 HMDB CHEBI:506227 ChEBI 9606 TAXONOMY CHEBI:15366 ChEBI ReactionCatalysis113 ACTIVATION ReactionCatalysis114 ACTIVATION 389249 ChemSpider ReactionCatalysis111 ACTIVATION 389248 ChemSpider ReactionCatalysis112 ACTIVATION ReactionCatalysis110 ACTIVATION Q13231 UniProt 392413 ChemSpider HMDB00290 HMDB HMDB00051 HMDB 1.0 HMDB00295 HMDB SMILES CC(=O)NC1[C@H](O)OC(CO)[C@@H](COC[C@@H]2OC(CO)[C@@H](COC[C@@H]3OC(CO)[C@@H](O)[C@H](O)C3NC(C)=O)[C@H](O)C2NC(C)=O)[C@@H]1O HMDB02111 HMDB Q96EK6 UniProt 1.0 N-Acetyl-glucosamine 1-phosphate N-acetyl-D-glucosamine kinase Amino Sugar Metabolism ReactionCatalysis108 ACTIVATION ReactionCatalysis109 ACTIVATION 171 ChemSpider CHEBI:32816 ChEBI ReactionCatalysis107 ACTIVATION 1.0 CHEBI:15377 ChEBI CHEBI:17677 ChEBI C20H31N4O16P Cytidine monophosphate N-acetylneuraminic acid 614.1473 C00645 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 4.0 1.0 Phosphate 1.0 PW000008 PathWhiz 1.0 CHEBI:16556 ChEBI HMDB01367 HMDB HMDB01129 HMDB Q9UJ70 UniProt Acetic acid SMILES N[C@@H](CCC(N)=O)C(O)=O 1.0 30776539 ChemSpider HMDB01121 HMDB ReactionCatalysis128 ACTIVATION ReactionCatalysis129 ACTIVATION ReactionCatalysis126 ACTIVATION ReactionCatalysis127 ACTIVATION HMDB03556 HMDB ReactionCatalysis124 ACTIVATION 1060 PubChem-compound 63-39-8 CAS 1061 PubChem-compound ReactionCatalysis125 ACTIVATION ReactionCatalysis122 ACTIVATION ReactionCatalysis123 ACTIVATION ReactionCatalysis120 ACTIVATION CHEBI:17659 ChEBI ReactionCatalysis121 ACTIVATION N-Acetylneuraminic acid SMILES CC(=O)N[C@@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O CHEBI:15351 ChEBI HMDB00042 HMDB SMILES OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O HMDB01254 HMDB HMDB00285 HMDB 1.0 176