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Pathway Description
Ammonia Recycling
Homo sapiens
Metabolic Pathway
Ammonia can be rerouted from the urine and recycled into the body for use in nitrogen metabolism. Glutamate and glutamine play an important role in this process. There are many other processes that act to recycle ammonia. asparaginase recycles ammonia from asparagine. Glycine cleavage system generates ammonia from glycine. Histidine ammonia lyase forms ammonia from histidine. Serine dehydratase also produces ammonia by cleaving serine.
References
Ammonia Recycling References
Lehninger, A.L. Lehninger principles of biochemistry (4th ed.) (2005). New York: W.H Freeman.
Salway, J.G. Metabolism at a glance (3rd ed.) (2004). Alden, Mass.: Blackwell Pub.
Kikuchi G: The glycine cleavage system: composition, reaction mechanism, and physiological significance. Mol Cell Biochem. 1973 Jun 27;1(2):169-87.
Pubmed: 4585091
Saparov SM, Liu K, Agre P, Pohl P: Fast and selective ammonia transport by aquaporin-8. J Biol Chem. 2007 Feb 23;282(8):5296-301. doi: 10.1074/jbc.M609343200. Epub 2006 Dec 21.
Pubmed: 17189259
Soria LR, Fanelli E, Altamura N, Svelto M, Marinelli RA, Calamita G: Aquaporin-8-facilitated mitochondrial ammonia transport. Biochem Biophys Res Commun. 2010 Mar 5;393(2):217-21. doi: 10.1016/j.bbrc.2010.01.104. Epub 2010 Feb 2.
Pubmed: 20132793
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