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Cytochrome P450 1A2 Cytochrome P450 1A2 Cytochrome P450 2E1 Arylamine N- acetyltransferase 2 Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 2C8 Cytochrome P450 2C9 Cytochrome P450 2E1 Cytochrome P450 1A2 Cytochrome P450 1A2 Xanthine dehydrogenase/oxidase Xanthine dehydrogenase/oxidase Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 2C8 Cytochrome P450 2C9 Cytochrome P450 2E1 Cytochrome P450 1A2 Cytochrome P450 2A6 Xanthine dehydrogenase/oxidase 5-Acetylamino-6-formylamino- 3-methyluracil 5-Acetylamino-6-amino-3- methyluracil Caffeine NADH O2 Paraxanthine NAD H2O Formaldehyde NADH O2 Theobromine NAD H2O Formaldehyde Acetyl-CoA CoA NADH O2 Theophylline NAD H2O Formaldehyde NADH O2 7-Methylxanthine NAD H2O Formaldehyde NADH O2 1-Methylxanthine NAD H2O Formaldehyde H2O O2 1-Methyluric acid H2O2 O2 H2O 7-Methyluric acid H2O2 O2 H2O 1,3,7-Trimethyluric acid H2O2 O2 H2O 1,7-Dimethyluric acid H2O2 H2O O2 3,7-Dimethyluric acid H2O2 Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme FAD 2Fe-2S Molybdopterin FAD 2Fe-2S Molybdopterin Heme Heme Heme Heme Heme Heme Heme FAD 2Fe-2S Molybdopterin Endoplasmic Reticulum ER Membrane ER Lumen Lysosome Lysosomal Lumen Lysosomal Membrane Liver
Endoplasmic Reticulum Lysosome CYP1A2 CYP1A2 CYP2E1 NAT2 CYP1A2 CYP3A4 CYP2C8 CYP2C9 CYP2E1 CYP1A2 CYP1A2 XDH XDH CYP1A2 CYP3A4 CYP2C8 CYP2C9 CYP2E1 CYP1A2 CYP2A6 XDH 5- Acetylamino- 6- formylamino- 3- methyluracil 5- Acetylamino- 6-amino-3- methyluracil Caffeine NADH Oxygen Paraxanthine NAD Water Formaldehyde NADH Oxygen Theobromine NAD Water Formaldehyde Acetyl-CoA Coenzyme A NADH Oxygen Theophylline NAD Water Formaldehyde NADH Oxygen 7- Methylxanthine NAD Water Formaldehyde NADH Oxygen 1- Methylxanthine NAD Water Formaldehyde Water Oxygen 1-Methyluric acid Hydrogen peroxide Oxygen Water 7-Methyluric acid Hydrogen peroxide Oxygen Water 1,3,7- Trimethyluric acid Hydrogen peroxide Oxygen Water 1,7- Dimethyluric acid Hydrogen peroxide Water Oxygen 3,7- Dimethyluric acid Hydrogen peroxide