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Cytochrome P450 1A2 Cytochrome P450 1A2 Cytochrome P450 2E1 Arylamine N- acetyltransferase 2 Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 2C8 Cytochrome P450 2C9 Cytochrome P450 2E1 Cytochrome P450 1A2 Cytochrome P450 1A2 Xanthine dehydrogenase/oxidase Xanthine dehydrogenase/oxidase Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 2C8 Cytochrome P450 2C9 Cytochrome P450 2E1 Cytochrome P450 1A2 Cytochrome P450 2A6 Xanthine dehydrogenase/oxidase 5-Acetylamino-6-formylamino- 3-methyluracil 5-Acetylamino-6-amino-3- methyluracil Caffeine NADH O 2 Paraxanthine NAD H 2 O Formaldehyde NADH O 2 Theobromine NAD H 2 O Formaldehyde Acetyl-CoA CoA NADH O 2 Theophylline NAD H 2 O Formaldehyde NADH O 2 7-Methylxanthine NAD H 2 O Formaldehyde NADH O 2 1-Methylxanthine NAD H 2 O Formaldehyde H 2 O O 2 1-Methyluric acid H 2 O 2 O 2 H 2 O 7-Methyluric acid H 2 O 2 O 2 H 2 O 1,3,7-Trimethyluric acid H 2 O 2 O 2 H 2 O 1,7-Dimethyluric acid H 2 O 2 H 2 O O 2 3,7-Dimethyluric acid H 2 O 2 Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme FAD 2Fe-2S Molybdopterin FAD 2Fe-2S Molybdopterin Heme Heme Heme Heme Heme Heme Heme FAD 2Fe-2S Molybdopterin Endoplasmic Reticulum ER Membrane ER Lumen Lysosome Lysosomal Lumen Lysosomal Membrane Liver
Endoplasmic Reticulum Lysosome CYP1A2 CYP1A2 CYP2E1 NAT2 CYP1A2 CYP3A4 CYP2C8 CYP2C9 CYP2E1 CYP1A2 CYP1A2 XDH XDH CYP1A2 CYP3A4 CYP2C8 CYP2C9 CYP2E1 CYP1A2 CYP2A6 XDH 5- Acetylamino- 6- formylamino- 3- methyluracil 5- Acetylamino- 6-amino-3- methyluracil Caffeine NADH Oxygen Paraxanthine NAD Water Formaldehyde NADH Oxygen Theobromine NAD Water Formaldehyde Acetyl-CoA Coenzyme A NADH Oxygen Theophylline NAD Water Formaldehyde NADH Oxygen 7- Methylxanthine NAD Water Formaldehyde NADH Oxygen 1- Methylxanthine NAD Water Formaldehyde