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Pathway Description
Cysteine Metabolism
Homo sapiens
Metabolic Pathway
The semi-essential amino aid cysteine is tightly regulated in the body to ensure proper levels for metabolism but maintaining levels below toxic thresholds. Cysteine can be obtained from diet or synthesized from O-acetyl-L-serine. Cystine is the dimeric form of cysteine. Cysteine is a precursor for protein synthesis and an antioxidant. Impaired cysteine metabolism has been linked with neurodegenerative disorders.
References
Cysteine Metabolism References
Lehninger, A.L. Lehninger principles of biochemistry (4th ed.) (2005). New York: W.H Freeman.
Salway, J.G. Metabolism at a glance (3rd ed.) (2004). Alden, Mass.: Blackwell Pub.
Stipanuk MH, Dominy JE Jr, Lee JI, Coloso RM: Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J Nutr. 2006 Jun;136(6 Suppl):1652S-1659S. doi: 10.1093/jn/136.6.1652S.
Pubmed: 16702335
Paul BD, Sbodio JI, Snyder SH: Cysteine Metabolism in Neuronal Redox Homeostasis. Trends Pharmacol Sci. 2018 May;39(5):513-524. doi: 10.1016/j.tips.2018.02.007. Epub 2018 Mar 9.
Pubmed: 29530337
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