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Pathway Description

D-Arginine and D-Ornithine Metabolism

Homo sapiens

Metabolic Pathway

D-Amino acids have been show to be present in high concentrations in humans and play a role in biological functions. D-Amino may have negative effects as they can be found in some bacteria or form spontaneously in certain reactions. D-Amino acid oxidase (DAAO) is one of the main enzymes that metabolize D-Amino acids via deamination. DAAO is highly specific towards D-amino acids and favours free neutral D-amino acids or those with hydrophobic, polar or aromatic groups. Acidic amino acids are not catalyze by DAOO.

References

D-Arginine and D-Ornithine Metabolism References

Lehninger, A.L. Lehninger principles of biochemistry (4th ed.) (2005). New York: W.H Freeman.

Salway, J.G. Metabolism at a glance (3rd ed.) (2004). Alden, Mass.: Blackwell Pub.

Genchi G: An overview on D-amino acids. Amino Acids. 2017 Sep;49(9):1521-1533. doi: 10.1007/s00726-017-2459-5. Epub 2017 Jul 5.

Pubmed: 28681245

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