PathWhiz

Pathway Description

Fatty Acid Metabolism

Homo sapiens

Metabolic Pathway

Fatty acids constitute a large energy source for the body. The cellular membrane is also made up of fatty acids. During starvation times, fatty acids can provide energy to humans for numerous days. Fatty acid metabolism is also known as beta-oxidation. During metabolism, acetyl CoA is produced that can then enter the citric acid cycle. When ATP is needed, ATP may be generated by increasing fatty acid metabolism. Fatty acid metabolism is essentially the reverse reaction of fatty acid synthesis.

References

Fatty Acid Metabolism References

Lehninger, A.L. Lehninger principles of biochemistry (4th ed.) (2005). New York: W.H Freeman.

Lodish, H. et al. Molecular cell biology. (2004) New York: W.H Freeman.

Salway, J.G. Metabolism at a glance (3rd ed.) (2004). Alden, Mass.: Blackwell Pub.

Vance, D.E., and Vance, J.E. Biochemistry of lipids, lipoproteins, and membranes (4th ed.) (2002) Amsterdam; Boston: Elsevier.

Wakil SJ, Abu-Elheiga LA: Fatty acid metabolism: target for metabolic syndrome. J Lipid Res. 2009 Apr;50 Suppl:S138-43. doi: 10.1194/jlr.R800079-JLR200. Epub 2008 Dec 1.

Pubmed: 19047759

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		(2E)-Decenoyl-CoA
		(2E)-Hexadecenoyl-CoA
		(2E)-Hexenoyl-CoA
		(2E)-Octenoyl-CoA
		(2E)-Tetradecenoyl-CoA
		3-Hydroxybutyryl-CoA
		3-Hydroxydecanoyl-CoA
		3-Hydroxydodecanoyl-CoA
		3-Hydroxyhexadecanoyl-CoA
		3-Hydroxyhexanoyl-CoA
		3-hydroxyoctanoyl-CoA
		3-Hydroxytetradecanoyl-CoA
		3-oxodecanoyl-CoA
		3-oxododecanoyl-CoA
		3-oxohexadecanoyl-CoA
		3-oxohexanoyl-CoA
		3-oxooctanoyl-CoA
		3-oxotetradecanoyl-CoA
		Acetoacetyl-CoA
		Acetyl-CoA
		Adenosine monophosphate
		Adenosine triphosphate
		Butyryl-CoA
		Carbon dioxide
		Coenzyme A
		Crotonoyl-CoA
		Decanoyl-CoA
		FAD
		Glutaryl-CoA
		Hexanoyl-CoA
		Hydrogen Ion
		L-Carnitine
		L-Palmitoylcarnitine
		Lauroyl-CoA
		Magnesium
		NAD
		NADH
		Octanoyl-CoA
		Palmitic acid
		Palmitoyl-CoA
		Pyrophosphate
		Tetradecanoyl-CoA
		Water

Visualize Protein Data

		3-ketoacyl-CoA thiolase, mitochondrial
		Acetyl-CoA acetyltransferase, mitochondrial
		Carnitine O-palmitoyltransferase 1, liver isoform
		Carnitine O-palmitoyltransferase 2, mitochondrial
		Enoyl-CoA hydratase, mitochondrial
		Glutaryl-CoA dehydrogenase, mitochondrial
		Long-chain specific acyl-CoA dehydrogenase, mitochondrial
		Long-chain-fatty-acid--CoA ligase 1
		Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
		Short-chain specific acyl-CoA dehydrogenase, mitochondrial
		Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
		Trifunctional enzyme subunit alpha, mitochondrial
		Trifunctional enzyme subunit beta, mitochondrial
		Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

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