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Pathway Description
Glycerol Phosphate Shuttle
Homo sapiens
Metabolic Pathway
The glycerol phosphate shuttle also known as the glycerophosphate shuttle. It shuttles electrons to mitochondrial carriers in the oxidative phosphorylation pathway from cytosolic NADH. This shuttle relies on mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH). This is also a common process for the cell to regenerate cytosolic NAD+ for other processes.
References
Glycerol Phosphate Shuttle References
Lehninger, A.L. Lehninger principles of biochemistry (4th ed.) (2005). New York: W.H Freeman.
Salway, J.G. Metabolism at a glance (3rd ed.) (2004). Alden, Mass.: Blackwell Pub.
Mracek T, Drahota Z, Houstek J: The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues. Biochim Biophys Acta. 2013 Mar;1827(3):401-10. doi: 10.1016/j.bbabio.2012.11.014. Epub 2012 Dec 7.
Pubmed: 23220394
Orr AL, Ashok D, Sarantos MR, Ng R, Shi T, Gerencser AA, Hughes RE, Brand MD: Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase. PLoS One. 2014 Feb 24;9(2):e89938. doi: 10.1371/journal.pone.0089938. eCollection 2014.
Pubmed: 24587137
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