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Pathway Description
Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Homo sapiens
Protein Pathway
The 5-HT4 receptor is primarily found in the CNS, GI tract, and PNS. Peripheral receptors have important roles in the function of many organ responses (alimentary tract, urinary bladder, heart, and adrenal gland). Alimentary tract receptors have a role in smooth muscle tone, mucosal electrolyte secretion, and the peristaltic reflex. Urinary bladder receptors control cholinergic/purinergic transmission. Atrial heart receptors produce positive inotropy and tachycardia that can precipitate arrhythmias. This receptor is also thought to have roles in anxiety, appetite, GI motility, learning, memory, mood, and respiration. The 5-HT4 receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response.
References
Excitatory Neural Signalling Through 5-HTR 4 and Serotonin References
Hegde SS, Eglen RM: Peripheral 5-HT4 receptors. FASEB J. 1996 Oct;10(12):1398-407.
Pubmed: 8903510
Payne RW, Savage BF: Vitamin B12 for vegans. Br Med J. 1977 Aug 13;2(6084):458.
Pubmed: 890351
Krauss, G. Biochemistry of signal transduction and regulation. (3rd ed.) (2003) Weinheim; New York : Wiley-VCH
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